ChemicalBook > CAS DataBase List > CP-724714

CP-724714

Product Name
CP-724714
CAS No.
537705-08-1
Chemical Name
CP-724714
Synonyms
CS-521;CS-2401;CP-724714;(E/Z)-CP-724714;CP-724714 CP724714;CP-724714 USP/EP/BP;-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl);2H-1,4-Benzoxazine-7-carboxylicacid,3,8-dihydro-,methylester;(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)ca;(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)carba
CBNumber
CB52501007
Molecular Formula
C27H27N5O3
Formula Weight
469.54
MOL File
537705-08-1.mol
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CP-724714 Property

solubility 
≥23.5 mg/mL in DMSO; insoluble in H2O; ≥25.4 mg/mL in EtOH
form 
solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A2412
Product name
CP-724714
Packaging
5mg
Price
$85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0392155
Product name
(E)-ETHYL-(3-(4-((3-METHYL-4-((6-METHYLPYRIDIN-3-YL)OXY)PHENYL)AMINO)QUINAZOLIN-6-YL)ALLYL)CARBAMATE
Purity
95.00%
Packaging
5MG
Price
$499.15
Updated
2021/12/16
AK Scientific
Product number
X7480
Product name
(E)-Ethyl(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)pheny)amino)quinazolin-6-yl)allyl)carbamate
Packaging
25mg
Price
$540
Updated
2021/12/16
Chemenu
Product number
CM133309
Product name
ethyl(E)-(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate
Purity
95%
Packaging
5g
Price
$795
Updated
2021/12/16
DC Chemicals
Product number
DC8892
Product name
CP724714
Purity
>98%
Packaging
250mg
Price
$900
Updated
2021/12/16
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CP-724714 Chemical Properties,Usage,Production

Uses

CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM.

Biological Activity

cp-724714 is an inhibitor of erbb2 and egfr kinases with ic50 values of 10±3 nmol/l and 6,400±2,100 nmol/l, respectively [1].in the in vitro cell cycle assay, cp-724714 cause a g1 block of the her2-amplified bt-474 breast cancer cells due to its inhibition of erbb2. cp-724714 at 1 mol/l can also reduce the level of phospho-erbb2 in these cells. in in vivo assay, cp-724714 cause a concentration-dependent reduction of tumor erbb2 receptor phosphorylation in athymic mice bearing fre-erbb2xenografts. cp-724714 treatments also resulted in a time- and dose-dependent induction of tumor cell apoptosis. in two human breast carcinoma models, bt-474 and mda-mb-453, which are her2 amplified and highly overexpress erbb2, cp-724714 is found to produce a dose-dependent inhibition of xenograft growth. in addition, cp-724,714 treatments induce reduction of downstream erbb2 rtk signaling. on the basis of these, cp-724,714 was advanced to phase i clinical trials and is potentially another option for her2-driven breast cancer [1].

target

erbB2

References

[1] jitesh p. jani, richard s. finn, mary campbell, et al. discovery and pharmacologic characterization of cp-724714, a selective erbb2 tyrosine kinase inhibitor. cancer research. 2007 (67): 9887-9893.

CP-724714 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-724714 Suppliers

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View Lastest Price from CP-724714 manufacturers

Career Henan Chemical Co
Product
CP-724714 537705-08-1
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-12

537705-08-1, CP-724714Related Search:

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  • (E)-Ethyl (3-(4-((3-Methyl-4-((6-Methylpyridin-3-yl)oxy)phenyl)aMino)quinazolin-6-yl)allyl)carbaMate
  • acetaMide, 2-Methoxy-N-[3-[4-[[3-Methyl-4-[(6-Methyl-3-pyridinyl)oxy]phenyl]aMino]-6-quinazolinyl]-2-propen-1-yl]-
  • (E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)carba
  • CP-724714
  • 2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
  • (E)-2-Methoxy-N-(3-(4-(3-Methyl-4-(6-Methylpyridin-3-yloxy)phenylaMino)quinazolin-6-yl)allyl)acetaMide
  • -Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)
  • (E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)ca
  • CS-2401
  • CS-521
  • 2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]acetamide
  • CP-724714 USP/EP/BP
  • (E/Z)-CP-724714
  • 2H-1,4-Benzoxazine-7-carboxylicacid,3,8-dihydro-,methylester
  • CP-724714 CP724714
  • 537705-08-1
  • Inhibitors