CP-724714
- Product Name
- CP-724714
- CAS No.
- 537705-08-1
- Chemical Name
- CP-724714
- Synonyms
- CS-521;CS-2401;CP-724714;(E/Z)-CP-724714;CP-724714 CP724714;CP-724714 USP/EP/BP;-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl);2H-1,4-Benzoxazine-7-carboxylicacid,3,8-dihydro-,methylester;(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)ca;(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)carba
- CBNumber
- CB52501007
- Molecular Formula
- C27H27N5O3
- Formula Weight
- 469.54
- MOL File
- 537705-08-1.mol
CP-724714 Property
- solubility
- ≥23.5 mg/mL in DMSO; insoluble in H2O; ≥25.4 mg/mL in EtOH
- form
- solid
N-Bromosuccinimide Price
- Product number
- A2412
- Product name
- CP-724714
- Packaging
- 5mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CHM0392155
- Product name
- (E)-ETHYL-(3-(4-((3-METHYL-4-((6-METHYLPYRIDIN-3-YL)OXY)PHENYL)AMINO)QUINAZOLIN-6-YL)ALLYL)CARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.15
- Updated
- 2021/12/16
- Product number
- X7480
- Product name
- (E)-Ethyl(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)pheny)amino)quinazolin-6-yl)allyl)carbamate
- Packaging
- 25mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CM133309
- Product name
- ethyl(E)-(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate
- Purity
- 95%
- Packaging
- 5g
- Price
- $795
- Updated
- 2021/12/16
- Product number
- DC8892
- Product name
- CP724714
- Purity
- >98%
- Packaging
- 250mg
- Price
- $900
- Updated
- 2021/12/16
CP-724714 Chemical Properties,Usage,Production
Uses
CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM.
Biological Activity
cp-724714 is an inhibitor of erbb2 and egfr kinases with ic50 values of 10±3 nmol/l and 6,400±2,100 nmol/l, respectively [1].in the in vitro cell cycle assay, cp-724714 cause a g1 block of the her2-amplified bt-474 breast cancer cells due to its inhibition of erbb2. cp-724714 at 1 mol/l can also reduce the level of phospho-erbb2 in these cells. in in vivo assay, cp-724714 cause a concentration-dependent reduction of tumor erbb2 receptor phosphorylation in athymic mice bearing fre-erbb2xenografts. cp-724714 treatments also resulted in a time- and dose-dependent induction of tumor cell apoptosis. in two human breast carcinoma models, bt-474 and mda-mb-453, which are her2 amplified and highly overexpress erbb2, cp-724714 is found to produce a dose-dependent inhibition of xenograft growth. in addition, cp-724,714 treatments induce reduction of downstream erbb2 rtk signaling. on the basis of these, cp-724,714 was advanced to phase i clinical trials and is potentially another option for her2-driven breast cancer [1].
target
erbB2
References
[1] jitesh p. jani, richard s. finn, mary campbell, et al. discovery and pharmacologic characterization of cp-724714, a selective erbb2 tyrosine kinase inhibitor. cancer research. 2007 (67): 9887-9893.
CP-724714 Preparation Products And Raw materials
Raw materials
Preparation Products
CP-724714 Suppliers
View Lastest Price from CP-724714 manufacturers
- Product
- CP-724714 537705-08-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-12