ChemicalBook > CAS DataBase List > 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )

5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )

Product Name
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
CAS No.
1020719-62-3
Chemical Name
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
Synonyms
AMR69 D5;[2H5]-Pirfenidone;2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5-;2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5)-;Pirfenidone-d5 (5-Methyl-N-Phenyl-2-1H-Pyridone-d5)?;5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 );5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one;5-methyl-1-[(2,3,4,5,6-2H?)phenyl]-1,2-dihydropyridin-2-one;5-Methyl-1-(phenyl-2,3,4,5,6-d5)-2(1H)-pyridinone;Pirfenidone-d5Q: What is Pirfenidone-d5 Q: What is the CAS Number of Pirfenidone-d5 Q: What is the storage condition of Pirfenidone-d5 Q: What are the applications of Pirfenidone-d5
CBNumber
CB52511343
Molecular Formula
C12H11NO
Formula Weight
185.23
MOL File
1020719-62-3.mol
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5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Property

Melting point:
104-106°C
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly)
form 
Solid
color 
White to Light Beige
InChI
InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
InChIKey
ISWRGOKTTBVCFA-UHFFFAOYSA-N
SMILES
O=C1C=CC(C)=CN1C1C([H])=C([H])C([H])=C([H])C=1[H]
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26452
Product name
Pirfenidone-d5
Packaging
500μg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
26452
Product name
Pirfenidone-d5
Packaging
1mg
Price
$178
Updated
2024/03/01
TRC
Product number
M325898
Product name
5-Methyl-N-phenyl-2-1H-pyridone-d5(Pirfenidone-d5)
Packaging
10mg
Price
$1230
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0007218
Product name
5-METHYL-N-PHENYL-2-1H-PYRIDONE-D5
Purity
95.00%
Packaging
10MG
Price
$1593.9
Updated
2021/12/16
AK Scientific
Product number
8703DU
Product name
5-Methyl-N-phenyl-2-1H-pyridone-d5
Packaging
1mg
Price
$370
Updated
2021/12/16
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5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Chemical Properties,Usage,Production

Description

Pirfenidone-d5 is intended for use as an internal standard for the quantification of pirfenidone by GC- or LC-MS. Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities. It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin . In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis. Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively). Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.

Chemical Properties

Off-White Solid

Uses

A deuterated metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.

5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Suppliers

Canada 1 China 29 India 2 United States 9 Global 41
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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94657
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Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
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58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
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58
Artis Biotech Co. Ltd.
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0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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9806
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Shanghai Champ Biopharmaceuticals Co., Ltd.
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021-61537865 13585780846
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sales@champchem.com
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China
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360
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131957
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Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Fax
028-85255396
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cdnovell@163.com
Country
China
ProdList
2314
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58
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
Email
sales@glpbio.cn
Country
China
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6777
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58

1020719-62-3, 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )Related Search:

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  • 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
  • 2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5-
  • 5-Methyl-1-(phenyl-2,3,4,5,6-d<sub>5</sub>)-2(1H)-pyridinone
  • 5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one
  • AMR69 D5
  • [2H5]-Pirfenidone
  • 2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5)-
  • Pirfenidone-d5 (5-Methyl-N-Phenyl-2-1H-Pyridone-d5)?
  • Pirfenidone-d5Q: What is Pirfenidone-d5 Q: What is the CAS Number of Pirfenidone-d5 Q: What is the storage condition of Pirfenidone-d5 Q: What are the applications of Pirfenidone-d5
  • 5-methyl-1-[(2,3,4,5,6-2H?)phenyl]-1,2-dihydropyridin-2-one
  • 1020719-62-3
  • Aromatics
  • Isotope Labelled Compounds
  • Metabolites