ChemicalBook > CAS DataBase List > OSI-930

OSI-930

Product Name
OSI-930
CAS No.
728033-96-3
Chemical Name
OSI-930
Synonyms
OSI-930;CS-1804;OSI-930; OSI930;OSI-930 USP/EP/BP;OSI-930 Kit VEGFR 2 inhibitorOSI930;3-(Quinolin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide;3-[(4-Quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide;2-Thiophenecarboxamide, 3-[(4-quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-;3-[(4-Quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide OSI930
CBNumber
CB52512522
Molecular Formula
C22H16F3N3O2S
Formula Weight
443.44
MOL File
728033-96-3.mol
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OSI-930 Property

Boiling point:
517.4±50.0 °C(Predicted)
Density 
1.450
storage temp. 
Store at -20°C
solubility 
≥22.15 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
11.36±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29379
Product name
OSI-930
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
29379
Product name
OSI-930
Packaging
50mg
Price
$812
Updated
2024/03/01
Cayman Chemical
Product number
29379
Product name
OSI-930
Packaging
10mg
Price
$208
Updated
2024/03/01
Cayman Chemical
Product number
29379
Product name
OSI-930
Packaging
25mg
Price
$459
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0005268
Product name
OSI-930
Purity
95.00%
Packaging
5MG
Price
$249.7
Updated
2021/12/16
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OSI-930 Chemical Properties,Usage,Production

Uses

OSI-930 is an inhibitor of the receptor tyrosine kinases c-Kit (IC50:9.5nM) and VEGFR-2 (IC50:10.1nM).

Definition

ChEBI: 3-(4-quinolinylmethylamino)-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide is an aromatic amide.

Biological Activity

osi-930 is a novel, potent inhibitor of flt1, kinase insert domain receptor (kdr), csf-1r, lck, c-raf and activated receptor tyrosine kinases kit with ic50 values of 8, 9, 15, 22, 41 and 80 nm, respectively [1].osi-930 has been demonstrated to inhibit proliferation and induce apoptosis in the hmc-1 cell line which is highly dependent on kit signaling for survival. on the contrary, osi-930 revealed no growth inhibition of colo-205 cell line under normal culture conditions [1].osi-930 has shown to time- and concentration-dependently inactivate p450 3a4. additionally, osi-930 could reduce co difference spectra of p450 3a4 [2].

target

c-Kit

References

[1] garton aj1, crew ap, franklin m, cooke ar, wynne gm, castaldo l, kahler j, winski sl, franks a, brown en, bittner ma, keily jf, briner p, hidden c, srebernak mc, pirrit c, o'connor m, chan a, vulevic b,henninger d, hart k, sennello r, li ah, zhang t, richardson f, emerson dl, castelhano al, arnold ld,gibson nw. osi-930: a novel selective inhibitor of kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models. cancer res. 2006 jan 15;66(2):1015-24.
[2] lin hl1, zhang h, medower c, hollenberg pf, johnson ww. inactivation of cytochrome p450 (p450) 3a4 but not p450 3a5 by osi-930, a thiophene-containing anticancer drug. drug metab dispos. 2011 feb;39(2):345-50.

OSI-930 Preparation Products And Raw materials

Raw materials

Preparation Products

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OSI-930 Suppliers

China 97 France 1 India 2 The Netherlands 1 United Kingdom 1 United States 16 Global 118
Angel Pharmatech, Ltd.
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View Lastest Price from OSI-930 manufacturers

Career Henan Chemical Co
Product
OSI-930 728033-96-3
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

728033-96-3, OSI-930Related Search:

4-methylquinoline Quinoline Nilotinib DCC-2036 (Rebastinib) Quizartinib (AC220) Linifanib (ABT-869) Tandutinib Sunitinib Malate

  • OSI-930
  • 3-[(4-Quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide
  • 3-(Quinolin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide
  • 3-[(4-Quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide OSI930
  • OSI-930; OSI930
  • CS-1804
  • 2-Thiophenecarboxamide, 3-[(4-quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-
  • OSI-930 USP/EP/BP
  • OSI-930 Kit VEGFR 2 inhibitorOSI930
  • 728033-96-3
  • Inhibitors