OSI-930
- Product Name
- OSI-930
- CAS No.
- 728033-96-3
- Chemical Name
- OSI-930
- Synonyms
- OSI-930;CS-1804;OSI-930; OSI930;OSI-930 USP/EP/BP;OSI-930 Kit VEGFR 2 inhibitorOSI930;3-(Quinolin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide;3-[(4-Quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide;2-Thiophenecarboxamide, 3-[(4-quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-;3-[(4-Quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide OSI930
- CBNumber
- CB52512522
- Molecular Formula
- C22H16F3N3O2S
- Formula Weight
- 443.44
- MOL File
- 728033-96-3.mol
OSI-930 Property
- Boiling point:
- 517.4±50.0 °C(Predicted)
- Density
- 1.450
- storage temp.
- Store at -20°C
- solubility
- ≥22.15 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 11.36±0.70(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29379
- Product name
- OSI-930
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 29379
- Product name
- OSI-930
- Packaging
- 50mg
- Price
- $812
- Updated
- 2024/03/01
- Product number
- 29379
- Product name
- OSI-930
- Packaging
- 10mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 29379
- Product name
- OSI-930
- Packaging
- 25mg
- Price
- $459
- Updated
- 2024/03/01
- Product number
- API0005268
- Product name
- OSI-930
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $249.7
- Updated
- 2021/12/16
OSI-930 Chemical Properties,Usage,Production
Uses
OSI-930 is an inhibitor of the receptor tyrosine kinases c-Kit (IC50:9.5nM) and VEGFR-2 (IC50:10.1nM).
Definition
ChEBI: 3-(4-quinolinylmethylamino)-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide is an aromatic amide.
Biological Activity
osi-930 is a novel, potent inhibitor of flt1, kinase insert domain receptor (kdr), csf-1r, lck, c-raf and activated receptor tyrosine kinases kit with ic50 values of 8, 9, 15, 22, 41 and 80 nm, respectively [1].osi-930 has been demonstrated to inhibit proliferation and induce apoptosis in the hmc-1 cell line which is highly dependent on kit signaling for survival. on the contrary, osi-930 revealed no growth inhibition of colo-205 cell line under normal culture conditions [1].osi-930 has shown to time- and concentration-dependently inactivate p450 3a4. additionally, osi-930 could reduce co difference spectra of p450 3a4 [2].
target
c-Kit
References
[1] garton aj1, crew ap, franklin m, cooke ar, wynne gm, castaldo l, kahler j, winski sl, franks a, brown en, bittner ma, keily jf, briner p, hidden c, srebernak mc, pirrit c, o'connor m, chan a, vulevic b,henninger d, hart k, sennello r, li ah, zhang t, richardson f, emerson dl, castelhano al, arnold ld,gibson nw. osi-930: a novel selective inhibitor of kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models. cancer res. 2006 jan 15;66(2):1015-24.
[2] lin hl1, zhang h, medower c, hollenberg pf, johnson ww. inactivation of cytochrome p450 (p450) 3a4 but not p450 3a5 by osi-930, a thiophene-containing anticancer drug. drug metab dispos. 2011 feb;39(2):345-50.
OSI-930 Preparation Products And Raw materials
Raw materials
Preparation Products
OSI-930 Suppliers
- Tel
- --
- Fax
- --
- sales@alsachim.com
- Country
- France
- ProdList
- 424
- Advantage
- 0
View Lastest Price from OSI-930 manufacturers
- Product
- OSI-930 728033-96-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24