3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
- Product Name
- 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
- CAS No.
- 491871-58-0
- Chemical Name
- 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
- Synonyms
- CS-1482;TCS PIM-1;SC 204330;TCS PIM-1 1;TCS PIM-1 1, >=98%;TCS PIM-1 1(sc-204330);SC 204330; TCS PIM 1-1;3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone;6-(5-Bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-
- CBNumber
- CB52518751
- Molecular Formula
- C18H11BrN2O2
- Formula Weight
- 367.2
- MOL File
- 491871-58-0.mol
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Property
- Boiling point:
- 592.6±50.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥12.8 mg/mL in DMSO
- form
- solid
- pka
- 6.93±0.10(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 16286
- Product name
- TCS PIM-1 1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 16286
- Product name
- TCS PIM-1 1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- 16286
- Product name
- TCS PIM-1 1
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $360
- Updated
- 2024/03/01
- Product number
- 16286
- Product name
- TCS PIM-1 1
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $672
- Updated
- 2024/03/01
- Product number
- 2979
- Product name
- TCSPIM-11
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $716
- Updated
- 2021/12/16
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Chemical Properties,Usage,Production
Uses
TCS PIM-1 1 is a Pim-1 kinase inhibitor.
Definition
ChEBI: 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone is a member of the class of pyridones that is 2-pyridone carrying cyano, phenyl and 3-bromo-6-hydroxyphenyl substituents at positions 3, 4 and 6 respectively It is a pyridone, a bromophenol and a nitrile.
Biological Activity
tcs pim-1 1 is a selective inhibitor of pim-1 with ic50 value of 50 nm [1].pim-1 is a proto-oncogene serine/threonine-protein kinase and plays an important role in cell cycle progression, apoptosis, transcriptional activation and more general signal transduction pathways. it has been shown that pim-1 over-expression is correlated with a variety of human cancers [2].tcs pim-1 1 is a potent pim-1 inhibitor and has a better selectivity to pim-1 than to pim-2. it was revealed that tcs pim-1 1 was the most potent inhibitor of pim-1 by outlining the crystal structure and it was also shown that tcs pim-1 1 had better inhibitory activity to pim-1 compared with pim-2 [1].
storage
Store at +4°C
References
[1]. cheney, i.w., et al., identification and structure-activity relationships of substituted pyridones as inhibitors of pim-1 kinase. bioorg med chem lett, 2007. 17(6): p. 1679-83.
[2]. cen, b., et al., the pim-1 protein kinase is an important regulator of met receptor tyrosine kinase levels and signaling. mol cell biol, 2014. 34(13): p. 2517-32.
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone manufacturers
- Product
- 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone 491871-58-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23