4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 41103-17-7
- Chemical Name
- 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- ETHYL 4-CHLOROPYRIMIDINE-5-CARBOXYLATE;4-Chloropyrimidin-5-carboxylic acid ethyl ester;4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER;5-Pyrimidinecarboxylic acid, 4-chloro-, ethyl ester;4-chloro-5-Pyrimidinecarboxylic acid ethyl ester (7CI 9CI ACI);5-Pyrimidinecarboxylic acid, 4-chloro-, ethyl ester (7CI, 9CI, ACI)
- CBNumber
- CB5252082
- Molecular Formula
- C7H7ClN2O2
- Formula Weight
- 186.6
- MOL File
- 41103-17-7.mol
4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Property
- Boiling point:
- 278.2±20.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -1.62±0.16(Predicted)
- form
- semi-solid
- color
- Yellow
- InChI
- InChI=1S/C7H7ClN2O2/c1-2-12-7(11)5-3-9-4-10-6(5)8/h3-4H,2H2,1H3
- InChIKey
- AZJAMMCCAZZXIK-UHFFFAOYSA-N
- SMILES
- C1=NC=C(C(OCC)=O)C(Cl)=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E903455
- Product name
- Ethyl4-Chloro-5-pyrimidinecarboxylate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- E903455
- Product name
- Ethyl4-Chloro-5-pyrimidinecarboxylate
- Packaging
- 25g
- Price
- $1935
- Updated
- 2021/12/16
- Product number
- FC57374
- Product name
- 4-Chloro-pyrimidine-5-carboxylic acid ethyl ester
- Packaging
- 250mg
- Price
- $62.5
- Updated
- 2021/12/16
- Product number
- 072288
- Product name
- Ethyl 4-chloropyrimidine-5-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- FC57374
- Product name
- 4-Chloro-pyrimidine-5-carboxylic acid ethyl ester
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
Ethyl 4-Chloro-5-pyrimidinecarboxylate is a reagent used in the synthesis of a series of novel orally active non-peptide angiotensin II antagonists.
Synthesis
4786-52-1
41103-17-7
Ethyl 4-hydroxy-5-pyrimidinecarboxylate (380 mg, 2.26 mmol) was dissolved in tetrahydrofuran (THF, 5 mL) and thionyl chloride (1.65 mL, 22.6 mmol) was added slowly. The reaction mixture was heated to reflux and kept for 4 hours. Upon completion of the reaction, the reaction solution was concentrated by rotary evaporator under reduced pressure to give 417 mg (99% yield) of ethyl 4-chloropyrimidine-5-carboxylate as crude product. The crude product could be used directly in the subsequent reaction without further purification or characterization.
References
[1] Patent: WO2006/91506, 2006, A2. Location in patent: Page/Page column 40
[2] Patent: WO2006/49681, 2006, A2. Location in patent: Page/Page column 38
[3] Patent: WO2006/121588, 2006, A2. Location in patent: Page/Page column 44
[4] Patent: WO2006/121860, 2006, A2. Location in patent: Page/Page column 44
[5] Patent: WO2006/121904, 2006, A1. Location in patent: Page/Page column 44
4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Suppliers
- Tel
- --
- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
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- 6005
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View Lastest Price from 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 41103-17-7
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-12
- Product
- 4-Chloro-pyrimidine-5-carboxylic acid ethyl ester 41103-17-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- Ethyl 4-Chloro-5-pyrimidinecarboxylate 41103-17-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-09