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Atopaxar

Product Name
Atopaxar
CAS No.
751475-53-3
Chemical Name
Atopaxar
Synonyms
E555;CS-666;E 5555;Atopaxa;Atopaxar;ER 172594-00;Atopaxar (E 5555);(943239-67-6) atopaxar;Atopaxar, 10 mM in DMSO;Benzoicacid,4-hydroxy-3,6-dimethoxy-
CBNumber
CB52521159
Molecular Formula
C29H38FN3O5
Formula Weight
527.63
MOL File
751475-53-3.mol
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Atopaxar Property

Boiling point:
671.0±65.0 °C(Predicted)
Density 
1.22
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (473.82 mM; Need ultrasonic)
pka
7.43±0.20(Predicted)
form 
Solid
color 
White to off-white
InChIKey
QWKAUGRRIXBIPO-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC(N2CCOCC2)=C(OC)C(C(C)(C)C)=C1)CN1CC2=C(C1=N)C(F)=C(OCC)C(OCC)=C2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3064
Product name
Atopaxar hydrobromide
Purity
≥98% (HPLC)
Packaging
5MG
Price
$158.24
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3064
Product name
Atopaxar hydrobromide
Purity
≥98% (HPLC)
Packaging
25MG
Price
$592
Updated
2025/07/31
DC Chemicals
Product number
DC9198
Product name
Atopaxar(E5555)
Purity
>98%
Packaging
100mg
Price
$750
Updated
2021/12/16
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Atopaxar Chemical Properties,Usage,Production

Definition

ChEBI: Atopaxar is an aromatic ketone.

Biological Activity

Atopaxar (E5555) is a potent, orally active, selective, reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. It can be used in the study of atherothrombotic diseases and interferes with platelet signaling..

in vitro

Atopaxar inhibits haTRAP (high-affinity thrombin receptor activating peptide) binding to PAR-1 on human platelet membranes in a concentration-dependent manner, with an IC 50 of 0.019 μM. < br/> Atopaxar inhibits human platelet aggregation induced by thrombin or TRAP in a concentration-dependent manner.
Atopaxar does not inhibit PRP (platelet-rich plasma) aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to a concentration of 20 μM.

in vivo

Atopaxar (30-100 mg/kg; po) causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model.
Atopaxar does not prolong bleeding time in guinea pigs at the highest tested dosage of 1000 mg/kg.

< td class="col1 fwb"> Result:
Animal Model: Guinea pigs, PIT model
Dosage: Oral administration
Administration: 10 mg/kg, 30 mg/kg, 100 mg/kg
Prolonged the time to occlusion by 1.8-fold and 2.4-fold at 30 mg/kg and 100 mg/kg, respectively, compared with controls.

target

PAR-1

Atopaxar Preparation Products And Raw materials

Raw materials

Preparation Products

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Atopaxar Suppliers

China 44 The Netherlands 1 United States 7 Global 52
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

751475-53-3, AtopaxarRelated Search:

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  • (943239-67-6) atopaxar
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  • Atopaxar
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  • E555
  • 1-(3-(tert-Butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone
  • Atopaxa
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  • Benzoicacid,4-hydroxy-3,6-dimethoxy-
  • E5555,platelets,Atopaxar,receptor-1,signaling,PAR-1,inhibit,E-5555,Inhibitor,receptor,Protease Activated Receptor (PAR),protease-activated,atherothrombotic,E 5555,thrombin,Thrombin receptors
  • Atopaxar, 10 mM in DMSO
  • 1-(3-(tert-butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethan-1-one
  • 751475-53-3
  • C29H38FN3O5
  • Inhibitors