ChemicalBook > CAS DataBase List > 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride

Product Name
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride
CAS No.
256499-19-1
Chemical Name
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride
Synonyms
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride;1-(2-Fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaMidine hydrochloride;Riociguat-10;Riociguat Impurity 3 HCl;Riociguat Impurity 2 HCl;Riociguat EP Impurity 10;Riociguanidine Intermediate;1-(2-Fluoro-benzyl)-1H-py...;1-(2-fluorobenzyl)-1H-pyrazolo;1-(2-Fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamidine
CBNumber
CB52525708
Molecular Formula
C14H13ClFN5
Formula Weight
305.74
MOL File
256499-19-1.mol
More
Less

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride Property

Melting point:
247-249oC
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White
InChI
InChI=1S/C14H12FN5.ClH/c15-11-6-2-1-4-9(11)8-20-14-10(5-3-7-18-14)12(19-20)13(16)17;/h1-7H,8H2,(H3,16,17);1H
InChIKey
DQASIYVADJWVLY-UHFFFAOYSA-N
SMILES
C(C1C=CC=CC=1F)N1N=C(C(N)=N)C2C=CC=NC1=2.Cl
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
F588235
Product name
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamideHydrochloride
Packaging
250mg
Price
$50
Updated
2021/12/16
TRC
Product number
F588235
Product name
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamideHydrochloride
Packaging
5g
Price
$250
Updated
2021/12/16
Matrix Scientific
Product number
068862
Product name
1-(2-Fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamidine hydrochloride
Purity
>95%
Packaging
5g
Price
$270
Updated
2021/12/16
AK Scientific
Product number
Y8461
Product name
1-(2-Fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamidinehydrochloride
Packaging
5g
Price
$311
Updated
2021/12/16
Matrix Scientific
Product number
068862
Product name
1-(2-Fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamidine hydrochloride
Purity
>95%
Packaging
25g
Price
$710
Updated
2021/12/16
More
Less

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride Chemical Properties,Usage,Production

Uses

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride is a key intermediate in the synthesis of Riociguat, a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.

Synthesis

In a 10 L four-necked flask, 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 919.7 g (3.646 mol, 10 eq), MeOH 7 L was added, and MeONa 295 g (5.469 mol, 1.5 eq) was added with stirring, and stirred at room temperature for 2 h. Has disappeared, completely converted to the intermediate (7), added CH 3 C0 2 H 329 g (5.469 mol, 1.5 eq), NH 4 C1 293 g (5.469 mol, 1.5 eq), heated to reflux overnight, TLC monitoring reaction completely The temperature was lowered, a large amount of solid was precipitated, filtered, and washed with DCM to give 981 g of white solid as 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide (8), which was used directly in the next step. The compound 8 981.0 g (3.646 mol, lO eq) was added to 5 L of methyl tert-butyl ether, stirred, suspended as a suspension, passed through HC1 gas for about 2.5 h, filtered, washed with DCM, and dried by filtration. 1103.7 g of white solid 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride. Total yield in two steps: 99.0%. Purity: 99%.

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride Suppliers

China 192 India 5 United States 4 Global 201
ANHUI JINGKE BIOTECHNOLOGY CO.,LTD
Tel
0551-65206518 18133676923
Email
taozz@kingobiotech.com
Country
China
ProdList
89
Advantage
58
Nanjing FuRuisi Medical Technology Co., Ltd.
Tel
025-83221260
Fax
02583221260
Email
renqing401@163.com
Country
China
ProdList
227
Advantage
55
Anhui Lianchuang Biological Medicine Co.,Ltd
Tel
0551-68779238 18056025720
Email
sales3@lcywhx.com
Country
China
ProdList
159
Advantage
57
Jinan XinKe Pharmaceutical Technology Co., Ltd.
Tel
0531-88259693 17854196142
Fax
0531-88259693
Email
2820602043@qq.com
Country
China
ProdList
100
Advantage
58
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9512
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Changzhou Joyous Chemical Co., Ltd.
Tel
0519-85607258
Fax
0519-85607278
Email
sales@joyouschem.com
Country
China
ProdList
294
Advantage
60
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Country
China
ProdList
4910
Advantage
58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
021-34666753 13311639313
Fax
+86-21-34979012
Email
info@shyrchem.com
Country
China
ProdList
571
Advantage
55
Shanghai Chainpharm Bio-medical Technology Co., Ltd.
Tel
021-61727342 13611721451
Fax
021-61294107
Email
sales@chainpharm.com
Country
China
ProdList
958
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5873
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10274
Advantage
55
Changzhou Yuanda Pharmaceutical Chemical Co., Ltd.
Tel
0519-83984084
Fax
0519-88776993
Email
sales@ydpharm.com
Country
China
ProdList
119
Advantage
60
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5798
Advantage
50
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7892
Advantage
55
Intelligence Pharm Science(Shanghai) Co., Ltd.
Tel
021-57898186
Fax
021-37699262
Country
China
ProdList
449
Advantage
55
Advanced carbon Organic Pharm Co., Ltd.
Tel
+86-021-60528262
Fax
+86-021-64306513
Email
sales@acopharm.com
Country
China
ProdList
94
Advantage
58
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
INTERCHEMIE NANJING PHARMATECH CO., LTD
Tel
13656237714 13656237714
Fax
0512-65852853
Email
xiaokunfu@kyyykj.com
Country
China
ProdList
296
Advantage
55
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q2816483246
Fax
QQ3382968513
Email
danping@shsendpharm.com
Country
China
ProdList
3096
Advantage
55
Hubei Xingxiwang Bio-technology Ltd
Tel
0715-8108888-8009
Fax
-
Email
3032618938@qq.com
Country
China
ProdList
47
Advantage
56
CHMA Chemical Technology (Shanghai) Co., Ltd
Tel
021-61556450 15800904410
Fax
021-61556450
Country
China
ProdList
2832
Advantage
58
Wuhan Bo-Sen Biological Technology Co., Ltd
Tel
027-51335350 15107175693
Fax
027-51335350
Email
bosenyuan@foxmail.com
Country
China
ProdList
192
Advantage
55
Jinan Putubio Tech Co., Ltd.
Tel
+86 (531) 8099-2215
Fax
+86 (531) 8099-2215
Email
putubio@outlook.com
Country
China
ProdList
1261
Advantage
55
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5010
Advantage
55
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7295
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9952
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Jiangsu C-jun Biotechnology Co., Ltd.
Tel
+86 (519) 8969-7536
Fax
+86 (519) 8988-9226
Email
sales3@cjxrpharm.com
Country
China
ProdList
217
Advantage
58
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876 13667159345
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
2000
Advantage
55
Wuhai Shuou Technology Co., Ltd.
Tel
17792809151
Fax
18872220797
Email
2355916837@ycphar.com
Country
China
ProdList
6133
Advantage
55
XinChang Yuan Jin Trading Co.,Ltd.
Tel
18951572016
Fax
0575-86176131
Email
xcyuanjin@jingxinpharm.com
Country
China
ProdList
170
Advantage
55
Suzhou Laihui Biotechnology Co., Ltd.
Tel
180-13160973 18013160973
Fax
0512-68236973
Email
rywaybio@gmail.com
Country
China
ProdList
298
Advantage
55
Hefei Hirisun Pharmatech Co., Ltd.
Tel
+86-0551-62678551 +86-15056975894
Fax
0551-62678551
Email
sales@hirisunpharm.com
Country
China
ProdList
181
Advantage
55
Nanjing LuoDa Chemical Co., Ltd
Tel
025-66016961 13382082786
Fax
025-52204547
Country
China
ProdList
289
Advantage
55
Nanijing m&m biotechnology Co. ,Ltd.
Tel
025-87782433 18021532344
Fax
025-87782433
Email
sales@marymebiotech.com
Country
China
ProdList
4000
Advantage
58
Wuhan Netcom Electronic Commerce Limited
Tel
18064670521
Fax
0757-88210752
Email
2355935187@ycphar.com
Country
China
ProdList
4879
Advantage
58
More
Less

View Lastest Price from 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride 256499-19-1
Price
US $0.00/g
Min. Order
1g
Purity
98.0%
Supply Ability
10kg/month
Release date
2021-12-17
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 1-[(2-fluorophenyl)methyl]-, hydrochloride (1:1) 256499-19-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100kgs
Release date
2024-12-20
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
Riociguanidine Intermediate 256499-19-1
Price
US $30.00-28.00/Kg
Min. Order
1Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2022-09-16

256499-19-1, 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide HydrochlorideRelated Search:

BENZENEAZOMALONONITRILE 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl)pyrimidin-5-yl)(ethyl)carbamate 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dimethyl-7,9-dihydro-8H-purin-8-one 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 1-(3-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dihydro-8H-purin-8-one 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-N5,N5- dimethylpyrimidine-4,5,6-triamine isopropyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaMide 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl) -7-methyl-7,9-dihydro-8H-purin-8-one Riociguat 4,6-PyriMidinediaMine, 2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(phenylazo)- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate

  • 1-(2-Fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaMidine hydrochloride
  • 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride
  • 1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide monohydrochloride
  • 1-(2-fluorobenzyl)-1H-pyrazolo 3,4-b pyridine-3-carboxiMidaMide HCL
  • 1-[(2-Fluorophenyl)Methyl]-1h-pyrazolo[3,4-b]pyridine-3-carboxiMidaMide hydrochloride
  • 1-(2-Fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamidine
  • 1-(2-Flurobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-carboxamidine hydrochloride
  • 1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide,1-[(2-fluorophenyl)methyl]-, monohydrochloride
  • 1-(2-FLUORO-BENZYL)-1H-PYRAZOL[3,4-B]PYRIDINE-3-CARBOXAMIDINE HYDROCHLORIDE
  • 1-(2-FLUORO-BENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXAMIDINE HCL
  • Riociguat-10
  • 1-(2-fluorobenzyl)-1H-pyrazolo
  • 1-[(2-FLUOROPHENYL)METHYL]-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXIMIDAMIDE ONOHYDROCHLORIDE
  • 1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide,1-[(2-fluorophe...
  • Riociguanidine Intermediate
  • 1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 1-[(2-fluorophenyl)methyl]-, hydrochloride (1:1)
  • 1-[(2-fluorophenyl)methyl]-1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride (1:1)
  • Riociguat Impurity 3 HCl
  • 1-(2-Fluoro-benzyl)-1H-py...
  • 1- (2-fluorobenzyl) -1H pyrazolo [3,4-B] pyridine-3-formamidine hydrochloride
  • IH-Pyrazolo[3,4-b]pyridine-3-carboximidamide,1- [(2-fluorophenyl)methyl]-,monohydrochloride
  • Riociguat Impurity 2 HCl
  • Riociguat EP Impurity 10
  • 256499-19-1
  • C14H12FN5ClH
  • C14H12FN5HCl
  • C14H13ClFN5