ChemicalBook > CAS DataBase List > 2-FLUORO-3-METHOXYBENZALDEHYDE

2-FLUORO-3-METHOXYBENZALDEHYDE

Product Name: 2-FLUORO-3-METHOXYBENZALDEHYDE
CAS No.: 103438-88-6
Chemical Name: 2-FLUORO-3-METHOXYBENZALDEHYDE
Synonyms: 2-Fluoro-3-formylanisole;2-FLUORO-3-METHOXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-3-methoxy-;2-Fluoro-3-methoxybenzaldehyde96%;2-Fluoro-3-methoxybenzaldehyde 96%;2-fluoro-3-methoxybenzaldehyde - [AC77538]
CBNumber: CB5253685
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 103438-88-6.mol

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2-FLUORO-3-METHOXYBENZALDEHYDE Property

Melting point:: 47-51 °C (lit.)
Boiling point:: 239.9±20.0 °C(Predicted)
Density: 1.192±0.06 g/cm3(Predicted)
Flash point:: 110 °C
storage temp.: Inert atmosphere,2-8°C
form: claggy powder
color: Sandy beige
Sensitive: Air Sensitive
CAS DataBase Reference: 103438-88-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-43
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 597260
Product name: 2-Fluoro-3-methoxybenzaldehyde
Purity: 97%
Packaging: 1g
Price: $37.7
Updated: 2023/06/20

Sigma-Aldrich

Product number: 597260
Product name: 2-Fluoro-3-methoxybenzaldehyde
Purity: 97%
Packaging: 5g
Price: $138
Updated: 2022/05/15

TRC

Product number: F593270
Product name: 2-Fluoro-3-methoxybenzaldehyde
Packaging: 2.5g
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: PC1746
Product name: 2-Fluoro-3-methoxybenzaldehyde
Purity: 99%
Packaging: 1g
Price: $21
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2615-3-32
Product name: 2-Fluoro-3-methoxybenzaldehyde
Purity: 99%
Packaging: 1g
Price: $24
Updated: 2021/12/16

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2-FLUORO-3-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White to yellow crystalline solid

Uses

2-Fluoro-3-methoxybenzaldehyde is an intermediate in the synthesis of benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.

Synthesis

693220-47-2

103438-88-6

GENERAL STEPS: To a solution of 2-fluoro-3,N-dimethoxy-N-methylbenzamide (2.30 g, 10.8 mmol) in tetrahydrofuran (THF, 20 mL) was slowly added a toluene solution of 1 M diisobutylaluminum hydride (DIBAL-H) (12 mL, 12 mmol) at -78°C. The reaction mixture was stirred at -78 °C for 3 h before an additional toluene solution of 1 M DIBAL-H (4.2 mL, 4.2 mmol) was added. Stirring was continued at -78 °C for 30 min, followed by slow warming of the reaction mixture to room temperature. Upon completion of the reaction, the reaction was carefully quenched with saturated aqueous ammonium chloride (NH4Cl) solution. The organic phase was separated and the aqueous phase was extracted with ethyl acetate (2 x 50 mL). The combined organic phases were washed sequentially with 1 N hydrochloric acid (HCl) and saturated brine. The organic phase was dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography eluting with a gradient of mixed solvents of ethyl acetate (EtOAc) and hexane (0:100 to 1:1) to afford the target compound 2-fluoro-3-methoxybenzaldehyde (1.41 g, 85% yield).1H NMR (300 MHz, CDCl3): δ 10.38 (1H, s), 7.43-7.40 (1H, m) , 7.24-7.15 (2H, m), 3.95 (3H, s).

References

[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 66 - 67
[2] Patent: WO2004/43904, 2004, A1. Location in patent: Page 62 - 63
[3] Patent: WO2004/43931, 2004, A1. Location in patent: Page 40-41

2-FLUORO-3-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-3-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 2-FLUORO-3-METHOXYBENZALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Fluoro-3-methoxybenzaldehyde 103438-88-6
Price: US $0.00-0.00/g
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Career Henan Chemical Co

Product: 2-Fluoro-3-methoxybenzaldehyde 103438-88-6
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-25

103438-88-6, 2-FLUORO-3-METHOXYBENZALDEHYDERelated Search:

6-CHLORO-2-FLUORO-3-METHOXYBENZALDEHYDE 3-Methoxy-2,4,5-trifluorobenzoic acid 3-METHOXY-2,4,5-TRIFLUOROBENZAMIDE 2,4-DIFLUORO-3-METHOXYBENZALDEHYDE 2,6-Difluoro-3-methoxyBenzaldehyde 2,4-DIFLUORO-3-METHOXY ACETOPHENONE 2,4,5-Trifluoro-3-methoxybenzoyl chloride 2,4-Difluoro-3-methoxybenzoic acid 2-FLUORO-3-METHOXYBENZALDEHYDE 2,6-DIFLUORO-3-METHOXYBENZOIC ACID 2-FLUORO-3-METHOXYBENZOIC ACID 2-CHLORO-6-FLUORO-3-METHOXYBENZALDEHYDE 5-FLUORO-2-METHOXYBENZALDEHYDE 2,3-Difluoro-4-methoxybenzaldehyde 6-bromo-2-fluoro-3-methoxybenzaldehyde 2-Fluoro-6-methoxybenzaldehyde 99%,2-FLUORO-6-METHOXYBENZALDEHYDE,2-Fluoro-6-methoxybenzaldehyde99% 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE 2,5-DIFLUORO-4-METHOXYBENZALDEHYDE

2-FLUORO-3-METHOXYBENZALDEHYDE

2-Fluoro-3-methoxybenzaldehyde 96%

2-Fluoro-3-methoxybenzaldehyde96%

2-Fluoro-3-formylanisole

Benzaldehyde, 2-fluoro-3-methoxy-

2-fluoro-3-methoxybenzaldehyde - [AC77538]

103438-88-6

C8H7O2F

FC6H3OCH3CHO

Organic Building Blocks

Carbonyl Compounds

Aldehydes

Building Blocks

Aryl Fluorinated Building Blocks

C7-C8

Carbonyl Compounds

Chemical Synthesis

Fluorinated Building Blocks

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Other Fluorinated Organic Building Blocks

Aldehydes

blocks

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Aldehyde

Aryl

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