5-FLUORO-2-METHOXYBENZALDEHYDE
- Product Name
- 5-FLUORO-2-METHOXYBENZALDEHYDE
- CAS No.
- 19415-51-1
- Chemical Name
- 5-FLUORO-2-METHOXYBENZALDEHYDE
- Synonyms
- 5-FLUORO-O-ANISALDEHYDE;5-Fluoro-o-anisaldehyde>5-Fluoro-o-methoxybenzaldehy;5-FLUORO-2-METHOXYBENZALDEHYDE;2-METHOXY-5-FLUOROBENZALDEHYDE;5-Fluoro-o-anisaldehyde;5-Fluoro-o-2-methoxybenzaldehyde;Benzaldehyde,5-fluoro-2-methoxy-;5-FLUORO-2-METHOXYBEZALDEHYDE, 96%;5-Fluoro-2-methoxybenzaldehyde,99%
- CBNumber
- CB9783142
- Molecular Formula
- C8H7FO2
- Formula Weight
- 154.14
- MOL File
- 19415-51-1.mol
5-FLUORO-2-METHOXYBENZALDEHYDE Property
- Melting point:
- 41-46 °C (lit.)
- Boiling point:
- 118 °C / 14mmHg
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to lump
- color
- White to Almost white
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 19415-51-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 37/39-26-36-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29130000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 523100
- Product name
- 5-Fluoro-2-methoxybenzaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/06/20
- Product number
- F0428
- Product name
- 5-Fluoro-o-anisaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- F0428
- Product name
- 5-Fluoro-o-anisaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $108
- Updated
- 2025/07/31
- Product number
- F401505
- Product name
- 5-Fluoro-2-methoxybenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- JK612860
- Product name
- 5-Fluoro-2-methoxybenzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
5-FLUORO-2-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Pale yellow powder and lumps
Uses
5-Fluoro-2-methoxybenzaldehyde may be used in the synthesis of 5-(5-fluoro-2-methoxyphenyl)imidazolidine-2,4-dione.
Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 3145, 1988 DOI: 10.1021/jo00249a004
Synthetic Communications, 19, p. 2001, 1989 DOI: 10.1080/00397918908052593
General Description
5-Fluoro-2-methoxybenzaldehyde is an aryl fluorinated building block.
Synthesis
452-08-4
68-12-2
19415-51-1
Synthesis of compound 1.2. 2-Bromo-4-fluoroanisole (100 g, 487.75 mmol, 1.00 equiv) and THF (1.5 L) were added to a 3000 mL three-necked round-bottomed flask under nitrogen protection. With stirring at -78 °C, n-butyllithium (n-BuLi, 215.6 mL) was added slowly and dropwise. The reaction mixture was continued stirring at -78 °C for 1 hour. Subsequently, N,N-dimethylformamide (DMF, 71.54 g, 978.79 mmol, 2.01 eq.) was added slowly and dropwise at the same temperature. The reaction system was warmed up to room temperature and stirred for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of 800 mL of aqueous ammonium chloride (NH4Cl aq.). The reaction mixture was extracted with 500 mL of ethyl acetate, the organic layers were combined and concentrated under reduced pressure. The crude product was purified by column chromatography to afford 65.7 g (87% yield) of 5-fluoro-2-methoxybenzaldehyde (1.2) as a light yellow solid.
References
[1] Patent: WO2017/91600, 2017, A1. Location in patent: Paragraph 0386-0387
[2] Patent: US2017/166584, 2017, A1. Location in patent: Paragraph 0418-0420
[3] Journal of Organic Chemistry, 2013, vol. 78, # 12, p. 5955 - 5963
5-FLUORO-2-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-FLUORO-2-METHOXYBENZALDEHYDE manufacturers
- Product
- 5-Fluoro-2-methoxybenzaldehyde 19415-51-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 5-FLUORO-2-METHOXYBENZALDEHYDE 19415-51-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02