2-Fluoro-4-methoxybenzaldehyde

Product Name: 2-Fluoro-4-methoxybenzaldehyde
CAS No.: 331-64-6
Chemical Name: 2-Fluoro-4-methoxybenzaldehyde
Synonyms: 2-FLUORO-P-ANISALDEHYDE;uoro-4-methoxybenzaL;2-Fluoro-p-anisaldehyde>2-fluoro-4-methoxybenzaldhyde;2-Fluor-4-methoxybenzaldehyde;2-FLUORO-4-METHOXYBENZALDEHYDE;2-fluor0-4-methoxybenzaldehyde;2-FLUORO-4-METHYOXYBENZALDEHYDE;2-FLUORO-4-METHYLOXYBENZALDEHYDE;2-Fluoro-4-methoxybenzaldehyde97%
CBNumber: CB9698631
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 331-64-6.mol

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2-Fluoro-4-methoxybenzaldehyde Property

Melting point:: 43-48 °C (lit.)
Boiling point:: 226.5±20.0 °C(Predicted)
Density: 1.192±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: 2-8°C
form: powder to crystal
color: White to Brown
Sensitive: Air Sensitive
BRN: 3237954
InChI: InChI=1S/C8H7FO2/c1-11-7-3-2-6(5-10)8(9)4-7/h2-5H,1H3
InChIKey: UNWQNFJBBWXFBG-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(OC)C=C1F
CAS DataBase Reference: 331-64-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-22
Safety Statements: 37/39-26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 528986
Product name: 2-Fluoro-4-methoxybenzaldehyde
Purity: 97%
Packaging: 25g
Price: $190
Updated: 2023/06/20

TCI Chemical

Product number: F0386
Product name: 2-Fluoro-p-anisaldehyde
Purity: >96.0%(GC)
Packaging: 5g
Price: $58
Updated: 2025/07/31

TCI Chemical

Product number: F0386
Product name: 2-Fluoro-p-anisaldehyde
Purity: >96.0%(GC)
Packaging: 25g
Price: $173
Updated: 2025/07/31

TRC

Product number: F593735
Product name: 2-Fluoro-4-methoxybenzaldehyde
Packaging: 10g
Price: $165
Updated: 2021/12/16

TRC

Product number: F593735
Product name: 2-Fluoro-4-methoxybenzaldehyde
Packaging: 25g
Price: $275
Updated: 2021/12/16

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2-Fluoro-4-methoxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline solid

Uses

2-Fluoro-4-methoxybenzaldehyde may be used in the preparation of:

fluorine containing 2,4,5-trisubstituted imidazole
1-(2-fluoro-4-methoxyphenyl)-2-propanone
6-(2-fluoro-4-methoxyphenyl)fulvene
10-(2-fluoro-4-methoxyphenyl)-6,7,9,10-tetrahydro-1Hfuro[3,4-b]pyrazolo[3,4-f]quinolin-9-one
polyhydroquinoline (PHQ)
3-(2-fluoro-4-methoxyphenyl) acrylic acid methyl ester

Uses

2-Fluoro-4-methoxybenzaldehyde was used in the synthesis of new analogues as inhibitors for phosphodiesterase 10A.

General Description

2-Fluoro-4-methoxybenzaldehyde is a fluorinated aromatic aldehyde. It can be prepared from 4-bromo-3-fluoroanisole.

Synthesis

26412-87-3

405-09-4

331-64-6

The general procedure for the synthesis of 2-fluoro-4-methoxybenzaldehyde from pyridine trioxide and 2-fluoro-4-methoxybenzyl alcohol was as follows: triethylamine (0.92 mL, 6.60 mmol) was added to a solution of 2-fluoro-4-methoxybenzyl alcohol (346.9 mg, 2.22 mmol) in DMSO (8 mL). Subsequently, pyridine sulfur trioxide (1.0501 g, 6.60 mmol) was added to the mixture in batches and the change in reaction temperature was monitored. The reaction mixture was stirred for 0.5 hours. After completion of the reaction, the mixture was poured into 5% aqueous KHSO4 solution and extracted three times with ethyl acetate, the organic layers were combined and dried over anhydrous MgSO4. The organic layer was concentrated under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: hexane/ether=5/1) to afford the target compound 2-fluoro-4-methoxybenzaldehyde (301 mg, 88% yield). The product was characterized by 1H-NMR (CDCl3): δ 10.21 (s, 1H), 7.83 (t, 1H, J=8.3 Hz), 6.79 (ddd, 1H, J=8.3, 2.3, 0.7 Hz), 6.65 (dd, 1H, J=12.2, 2.3 Hz), 3.88 (s, 3H).

References

[1] Patent: US6194461, 2001, B1

2-Fluoro-4-methoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-methoxybenzaldehyde Suppliers

Americas 1 Belgium 2 Canada 1 China 214 Europe 1 France 1 Germany 6 India 7 Italy 1 Japan 3 Switzerland 1 United Kingdom 24 United States 37 Global 299

Shanghai Sphchem Co., Ltd.

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View Lastest Price from 2-Fluoro-4-methoxybenzaldehyde manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Fluoro-4-methoxybenzaldehyde 331-64-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Speranza Chemical Co., Ltd.

Product: 2-Fluoro-4-methoxybenzaldehyde 331-64-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100MT/Year
Release date: 2024-11-06

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Fluoro-4-methoxybenzaldehyde 331-64-6
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

331-64-6, 2-Fluoro-4-methoxybenzaldehydeRelated Search:

o-Anisaldehyde (Trifluoromethoxy)benzene 2,4-Dimethoxybenzaldehyde Veratraldehyde 2-(Trifluoromethyl)benzaldehyde 3-Methoxybenzaldehyde 3-(Trifluoromethyl)benzaldehyde 2,5-Dimethoxybenzaldehyde 2,3-Dimethoxybenzaldehyde 2,6-Dimethoxybenzaldehyde 4-Hydroxybenzaldehyde 4-(Trifluoromethoxy)aniline 3,5-Dimethoxybenzaldehyde Benzaldehyde p-Anisaldehyde Fluorine 2-Fluoro-4-methoxyacetophenone 6-FLUOROVERATRALDEHYDE

2-fluor0-4-methoxybenzaldehyde

2-FLUORO-4-METHOXYBENZALDEHYDE

2-FLUORO-P-ANISALDEHYDE

2-Fluoro-4-methoxybenzaldehyde 97%

2-FLUORO-4-METHYLOXYBENZALDEHYDE

2-Fluoro-4-methoxybenzaldehyde97%

2-FLUORO-4-METHYOXYBENZALDEHYDE

2-Fluor-4-methoxybenzaldehyde

2-fluoro-4-methoxybenzaldhyde

2-Fluoro-4-methoxybenzaldehyde,2-Fluoro-p-anisaldehyde

2-Fluoro-p-anisaldehyde, 3-Fluoro-4-formylanisole

2-Fluoro-p-anisaldehyde&gt

uoro-4-methoxybenzaL

Benzaldehyde, 2-fluoro-4-methoxy-

331-64-6

331-64-4

ALDEHYDE

Organic Building Blocks

Carbonyl Compounds

C8

Building Blocks

Aldehydes

Halogenated Heterocycles ,Triazines ,Thiophenes

Adehydes, Acetals & Ketones

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds

Aromatic Aldehydes & Derivatives (substituted)

Benzene series

Benzaldehyde