2,5-Dimethoxybenzaldehyde
- Product Name
- 2,5-Dimethoxybenzaldehyde
- CAS No.
- 93-02-7
- Chemical Name
- 2,5-Dimethoxybenzaldehyde
- Synonyms
- Benzaldehyde, 2,5-dimethoxy-;34007;93-02--7;Benzaldehyde CRS;2,5-DiMethoxybenzaldehyde, 97% 25GR;NSC 6315;AKOS BBS-00003162;2,5-DimethoxybenzaL;2,5-Dimethoxybenzald;5-DiMethoxy benzaldehyde
- CBNumber
- CB6348890
- Molecular Formula
- C9H10O3
- Formula Weight
- 166.17
- MOL File
- 93-02-7.mol
2,5-Dimethoxybenzaldehyde Property
- Melting point:
- 46-48 °C (lit.)
- Boiling point:
- 146 °C/10 mmHg (lit.)
- Density
- 1.1708 (rough estimate)
- refractive index
- 1.5260 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 795mg/l
- form
- Crystalline Powder, Crystals and/or Chunks
- color
- Yellow to beige
- Water Solubility
- Soluble in chloroform and methanol. Slightly soluble in water.
- Sensitive
- Air Sensitive
- BRN
- 509301
- InChIKey
- AFUKNJHPZAVHGQ-UHFFFAOYSA-N
- LogP
- 1.910
- CAS DataBase Reference
- 93-02-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzaldehyde, 2,5-dimethoxy-(93-02-7)
- EPA Substance Registry System
- Benzaldehyde, 2,5-dimethoxy- (93-02-7)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37/39-24/25-36
- WGK Germany
- 2
- RTECS
- CU5740500
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29124900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D130605
- Product name
- 2,5-Dimethoxybenzaldehyde
- Purity
- 99%
- Packaging
- 25g
- Price
- $52.4
- Updated
- 2024/03/01
- Product number
- D130605
- Product name
- 2,5-Dimethoxybenzaldehyde
- Purity
- 99%
- Packaging
- 100g
- Price
- $118
- Updated
- 2024/03/01
- Product number
- D1111
- Product name
- 2,5-Dimethoxybenzaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $63
- Updated
- 2024/03/01
- Product number
- D1111
- Product name
- 2,5-Dimethoxybenzaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 250g
- Price
- $389
- Updated
- 2021/12/16
- Product number
- A19928
- Product name
- 2,5-Dimethoxybenzaldehyde, 98+%
- Packaging
- 25g
- Price
- $28
- Updated
- 2024/03/01
2,5-Dimethoxybenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline solid
Uses
2,5-Dimethoxybenzaldehyde is used in the preparation of 2,5-dimethoxyphenethylamine, which is utilized to prepare psychoactive drugs such as 2,5-dimethoxy-4-bromophenethylamine, 2,5-dimethoxy-4-iodophenethylamine and 4-Chloro-2,5-dimethoxy-phenethylamine. It acts as an intermediate in organic synthesis.
Application
2,5-Dimethoxybenzaldehyde, also known as 2C-H, is an organic compound and a benzaldehyde derivative. It can be used to produce 2,5-dimethoxyphenethylamine. 2C-H is also used to produce many other substituted phenethylamines such as 2C-B, 2C-I and 2C-C.
Preparation
2,5-Dimethoxybenzaldehyde synthesis: Anethole is oxidized to anisaldehyde , which after isolation is subjected to a BaeyerVilliger oxidation reaction with performic or peracetic acid. The O-formyl-4-methoxyphenol obtained this way is hydrolyzed . 4-Methoxyphenol is subsequently formylated using the Reimer-Tiemann method and the obtained 2-hydroxy-5-methoxybenzaldehyde is methylated with dimethylsulfate to 2,5-dimethoxybenzaldehyde.
Reaction
A : Anisaldehyde from anethole via oxidative cleavage: 20 g anise oil was suspended in a mixture of 150 mL water and 30 mL conc. sulfuric acid; addition of 55 g sodium bichromate at such a rate that the temperature did not exceed 40°C. The reaction mixture was extracted with 4 x 125 mL toluene and the solvent evaporated. The residual oil was vacuum distilled to yield 9.1 g anisaldehyde.
B : O-formyl-4-methoxyphenol: 6 mL anisaldehyde was dissolved in 75 mL dichloromethane (DCM). A mixture of 12 g hydrogen peroxide and 10 mL conc. formic acid was added over 30 min. The reaction mixture was gently refluxed for 21 h.
C: B 4-methoxyphenol: Evaporating the solvent from reaction mixture and taking up the residue in 100 mL aqueous NaOH (20%) (25 mL MeOH as co-solvent) yielded 4.1 g 4-methoxyphenol as a white crystalline product after the usual work-up and purification steps.
D : Reimer-Tiemann formylation of 4-methoxyphenol: 124.1 g 4-methoxyphenol was dissolved in NaOH solution (320 g NaOH in 400 mL water). In total, 161 mL chloroform was added. The usual work-up and steam distillation yielded 109.8 g of a clear yellow oil that did not solidify upon standing at room temperature (GC/MS: 94% 2-hydroxy-5-methoxybenzaldehyde).
E: D Methylation of 2-hydroxy-5-methoxybenzaldehyde: The yellow oil from was used without further purification. A 250 mL RB flask was charged with 100 mL acetone, 14 g anhydrous potassium carbonate and 10 g 2-hydroxy-5-methoxybenzaldehyde; the mixture was brought at reflux temperature and 11 g dimethyl sulfate was added. The reaction was continued for 4 hours. The solvent is evaporated and the crude end product crystallized in cold water. Recrystallization from EtOH/water yielded 8.3 g 2,5-dimethoxybenzaldehyde (GC/MS: 98%+ 2,5-dimethoxybenzaldehyde)
Definition
ChEBI: 2,5-dimethoxy-Benzaldehyde is a dimethoxybenzene.
2,5-Dimethoxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dimethoxybenzaldehyde manufacturers
- Product
- 2,5-Dimethoxybenzaldehyde 93-02-7
- Price
- US $999.00-800.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-22
- Product
- 2,5-Dimethoxybenzaldehyde 93-02-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-03-26
- Product
- 2,5-Dimethoxybenzaldehyde 93-02-7
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/Week
- Release date
- 2024-04-30