ChemicalBook > CAS DataBase List > 2,5-Dimethoxybenzaldehyde

2,5-Dimethoxybenzaldehyde

Product Name
2,5-Dimethoxybenzaldehyde
CAS No.
93-02-7
Chemical Name
2,5-Dimethoxybenzaldehyde
Synonyms
Benzaldehyde, 2,5-dimethoxy-;34007;93-02--7;Benzaldehyde CRS;2,5-DiMethoxybenzaldehyde, 97% 25GR;NSC 6315;AKOS BBS-00003162;2,5-DimethoxybenzaL;2,5-Dimethoxybenzald;5-DiMethoxy benzaldehyde
CBNumber
CB6348890
Molecular Formula
C9H10O3
Formula Weight
166.17
MOL File
93-02-7.mol
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2,5-Dimethoxybenzaldehyde Property

Melting point:
46-48 °C (lit.)
Boiling point:
146 °C/10 mmHg (lit.)
Density 
1.1708 (rough estimate)
refractive index 
1.5260 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
795mg/l
form 
Crystalline Powder, Crystals and/or Chunks
color 
Yellow to beige
Water Solubility 
Soluble in chloroform and methanol. Slightly soluble in water.
Sensitive 
Air Sensitive
BRN 
509301
InChIKey
AFUKNJHPZAVHGQ-UHFFFAOYSA-N
LogP
1.910
CAS DataBase Reference
93-02-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 2,5-dimethoxy-(93-02-7)
EPA Substance Registry System
Benzaldehyde, 2,5-dimethoxy- (93-02-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36/37/39-24/25-36
WGK Germany 
2
RTECS 
CU5740500
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29124900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D130605
Product name
2,5-Dimethoxybenzaldehyde
Purity
99%
Packaging
25g
Price
$52.4
Updated
2024/03/01
Sigma-Aldrich
Product number
D130605
Product name
2,5-Dimethoxybenzaldehyde
Purity
99%
Packaging
100g
Price
$118
Updated
2024/03/01
TCI Chemical
Product number
D1111
Product name
2,5-Dimethoxybenzaldehyde
Purity
>97.0%(GC)
Packaging
25g
Price
$63
Updated
2024/03/01
TCI Chemical
Product number
D1111
Product name
2,5-Dimethoxybenzaldehyde
Purity
>97.0%(GC)
Packaging
250g
Price
$389
Updated
2021/12/16
Alfa Aesar
Product number
A19928
Product name
2,5-Dimethoxybenzaldehyde, 98+%
Packaging
25g
Price
$28
Updated
2024/03/01
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2,5-Dimethoxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline solid

Uses

2,5-Dimethoxybenzaldehyde is used in the preparation of 2,5-dimethoxyphenethylamine, which is utilized to prepare psychoactive drugs such as 2,5-dimethoxy-4-bromophenethylamine, 2,5-dimethoxy-4-iodophenethylamine and 4-Chloro-2,5-dimethoxy-phenethylamine. It acts as an intermediate in organic synthesis.

Application

2,5-Dimethoxybenzaldehyde, also known as 2C-H, is an organic compound and a benzaldehyde derivative. It can be used to produce 2,5-dimethoxyphenethylamine. 2C-H is also used to produce many other substituted phenethylamines such as 2C-B, 2C-I and 2C-C.

Preparation

2,5-Dimethoxybenzaldehyde synthesis: Anethole is oxidized to anisaldehyde , which after isolation is subjected to a BaeyerVilliger oxidation reaction with performic or peracetic acid. The O-formyl-4-methoxyphenol obtained this way is hydrolyzed . 4-Methoxyphenol is subsequently formylated using the Reimer-Tiemann method and the obtained 2-hydroxy-5-methoxybenzaldehyde is methylated with dimethylsulfate to 2,5-dimethoxybenzaldehyde.
Reaction
A : Anisaldehyde from anethole via oxidative cleavage: 20 g anise oil was suspended in a mixture of 150 mL water and 30 mL conc. sulfuric acid; addition of 55 g sodium bichromate at such a rate that the temperature did not exceed 40°C. The reaction mixture was extracted with 4 x 125 mL toluene and the solvent evaporated. The residual oil was vacuum distilled to yield 9.1 g anisaldehyde.
B : O-formyl-4-methoxyphenol: 6 mL anisaldehyde was dissolved in 75 mL dichloromethane (DCM). A mixture of 12 g hydrogen peroxide and 10 mL conc. formic acid was added over 30 min. The reaction mixture was gently refluxed for 21 h.
C: B 4-methoxyphenol: Evaporating the solvent from reaction mixture and taking up the residue in 100 mL aqueous NaOH (20%) (25 mL MeOH as co-solvent) yielded 4.1 g 4-methoxyphenol as a white crystalline product after the usual work-up and purification steps.
D : Reimer-Tiemann formylation of 4-methoxyphenol: 124.1 g 4-methoxyphenol was dissolved in NaOH solution (320 g NaOH in 400 mL water). In total, 161 mL chloroform was added. The usual work-up and steam distillation yielded 109.8 g of a clear yellow oil that did not solidify upon standing at room temperature (GC/MS: 94% 2-hydroxy-5-methoxybenzaldehyde).
E: D Methylation of 2-hydroxy-5-methoxybenzaldehyde: The yellow oil from was used without further purification. A 250 mL RB flask was charged with 100 mL acetone, 14 g anhydrous potassium carbonate and 10 g 2-hydroxy-5-methoxybenzaldehyde; the mixture was brought at reflux temperature and 11 g dimethyl sulfate was added. The reaction was continued for 4 hours. The solvent is evaporated and the crude end product crystallized in cold water. Recrystallization from EtOH/water yielded 8.3 g 2,5-dimethoxybenzaldehyde (GC/MS: 98%+ 2,5-dimethoxybenzaldehyde)

Definition

ChEBI: 2,5-dimethoxy-Benzaldehyde is a dimethoxybenzene.

2,5-Dimethoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-Dimethoxybenzaldehyde Suppliers

Hebei Mojin Biotechnology Co.,ltd.
Tel
15097329902
Fax
18503279000
Email
bella@hbmojin.com
Country
China
ProdList
94
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Z IntellecChem& Tech. Co., Ltd
Tel
15050866711
Fax
QQ:2677337387
Email
saleszchem@163.com
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China
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Beijing Cooperate Pharmaceutical Co.,Ltd
Tel
+86-010-60279497 +86-15646567669
Fax
010-60279497
Email
sales01@cooperate-pharm.com
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China
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Z IntellecChem & Tech. Co., Ltd
Tel
13179383568; 15050866711
Fax
QQ:2677337387
Email
contact@zintellec.com
Country
China
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Wuhu Nuowei Chemical Technology Co., Ltd
Tel
0553-2911116 18055326116
Email
sales@nuowei-chem.com
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China
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309
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Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
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0519-85525329 15995069468
Fax
0519-85190960
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29526743@qq.com
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China
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Chongqing Yuzhiquan Biological Technology Co., Ltd.
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18306022109
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QQ:2966918840
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3236923470@qq.com
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China
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Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
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021-51816796-820 13611835272
Fax
021-5161 3951
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sales2@sunwaypharm.com
Country
China
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44499
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Shanghai Guoyuan Chemical Co., Ltd.
Tel
0512-55170668 13913095008
Fax
0512-55170668
Email
shgyhg@139.com
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China
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J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
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View Lastest Price from 2,5-Dimethoxybenzaldehyde manufacturers

Wuhan Xinhao Biotechnology Co., Ltd
Product
2,5-Dimethoxybenzaldehyde 93-02-7
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-03-08
Dorne Chemical Technology co. LTD
Product
2,5-Dimethoxybenzaldehyde 93-02-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20 tons
Release date
2024-03-26
Jinan Finer Chemical Co., Ltd
Product
2,5-Dimethoxybenzaldehyde 93-02-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
200mt
Release date
2020-12-08

93-02-7, 2,5-DimethoxybenzaldehydeRelated Search:


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