2,5-Dimethoxybenzylamine
- Product Name
- 2,5-Dimethoxybenzylamine
- CAS No.
- 3275-95-4
- Chemical Name
- 2,5-Dimethoxybenzylamine
- Synonyms
- Zilain;RARECHEM AL BW 0348;2,5-DimethoxybenzyL;2,5-Dimethoxybenzyla;2,5-DIMETHOXYBENZYLAMINE;2,5-dimethoxy-benzylamin;2,5-Dimethoxybenzylamine>2,5-Dimethoxybenzylamine ,98%;2,5-DiMethoxybenzeneMethanaMine;2,5-dimethoxy-benzenemethanamin
- CBNumber
- CB9403606
- Molecular Formula
- C9H13NO2
- Formula Weight
- 167.21
- MOL File
- 3275-95-4.mol
2,5-Dimethoxybenzylamine Property
- Boiling point:
- 95 °C/0.2 mmHg (lit.)
- Density
- 1.11 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.548(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 9.12±0.10(Predicted)
- form
- clear liquid
- color
- Colorless to Light orange to Yellow
- InChI
- 1S/C9H13NO2/c1-11-8-3-4-9(12-2)7(5-8)6-10/h3-5H,6,10H2,1-2H3
- InChIKey
- UWMCHDDHXMFKMA-UHFFFAOYSA-N
- SMILES
- COc1ccc(OC)c(CN)c1
- CAS DataBase Reference
- 3275-95-4(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-36/37/39-45
- RIDADR
- UN 2735 8/PG 3
- WGK Germany
- 3
- RTECS
- DP4430000
- HazardClass
- IRRITANT
- PackingGroup
- III
- HS Code
- 29222990
- Storage Class
- 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- Skin Corr. 1B
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D4023
- Product name
- 2,5-Dimethoxybenzylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $67
- Updated
- 2023/06/20
- Product number
- D4023
- Product name
- 2,5-Dimethoxybenzylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $195
- Updated
- 2023/06/20
- Product number
- D460935
- Product name
- 2,5-Dimethoxybenzylamine
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 4756-1-14
- Product name
- 2,5-Dimethoxybenzylamine
- Purity
- 98%
- Packaging
- 5G
- Price
- $147
- Updated
- 2021/12/16
- Product number
- JK289955
- Product name
- 2,5-Dimethoxybenzylamine
- Purity
- 98%
- Packaging
- 1g
- Price
- $17
- Updated
- 2021/12/16
2,5-Dimethoxybenzylamine Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liqui
Uses
2,5-Dimethoxybenzylamine reacts with ethyl bromoacetate to yield N-(2,5-dimethoxy)benzylglycine ethyl ester.
Uses
2,5-Dimethoxybenzylamine is used in the preparation of pyrrolo[2,3-b]pyrazine-7-carboxamide derivatives as JAK and SYK inhibitors for the treatment of autoimmune and inflammatory diseases.
Synthesis
Hexamethylenetetramine (urotropine) (2.1 g, 15.0 mmol) was dissolved in 60 mL of chloroform and heated to reflux; 2,5-dimethoxybenzyl bromide (2.97 g, 12.9 mmol) was dissolved in 60 mL of chloroform, then dripped into urotropine within 30 min, refluxed for 3 h, stored at 4 ?? overnight, and a white solid precipitated. After filtration, 2.33 g of white solid was obtained. The above solid was dissolved in the mixture [V (methanol): V (concentrated hydrochloric acid): V (water) = 42:12:10], heated to reflux for 3 d. Concentration was performed by adding 10 mL of water, adding 6 mol/L sodium hydroxide aqueous solution (about 40 mL) to adjust the pH to neutral, and then extracted with ether (50 mL??3), washed with saturated brine, and then concentrated by drying with anhydrous potassium carbonate to obtain 0.96 g of crude amine. The product was 0.96 g of crude amine, yield 44.5%.
2,5-Dimethoxybenzylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dimethoxybenzylamine manufacturers
- Product
- 2,5-Dimethoxybenzylamine 3275-95-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-20