ChemicalBook > CAS DataBase List > 5-FLUORO-2-METHOXYBENZALDEHYDE

5-FLUORO-2-METHOXYBENZALDEHYDE

Product Name: 5-FLUORO-2-METHOXYBENZALDEHYDE
CAS No.: 19415-51-1
Chemical Name: 5-FLUORO-2-METHOXYBENZALDEHYDE
Synonyms: 5-FLUORO-O-ANISALDEHYDE;5-Fluoro-o-anisaldehyde>5-Fluoro-o-methoxybenzaldehy;5-FLUORO-2-METHOXYBENZALDEHYDE;2-METHOXY-5-FLUOROBENZALDEHYDE;5-Fluoro-o-anisaldehyde;5-Fluoro-o-2-methoxybenzaldehyde;Benzaldehyde,5-fluoro-2-methoxy-;5-FLUORO-2-METHOXYBEZALDEHYDE, 96%;5-Fluoro-2-methoxybenzaldehyde,99%
CBNumber: CB9783142
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 19415-51-1.mol

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5-FLUORO-2-METHOXYBENZALDEHYDE Property

Melting point:: 41-46 °C (lit.)
Boiling point:: 118 °C / 14mmHg
Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to lump
color: White to Almost white
Sensitive: Air Sensitive
CAS DataBase Reference: 19415-51-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-22
Safety Statements: 37/39-26-36-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 523100
Product name: 5-Fluoro-2-methoxybenzaldehyde
Purity: 96%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: F0428
Product name: 5-Fluoro-o-anisaldehyde
Purity: >97.0%(GC)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: F0428
Product name: 5-Fluoro-o-anisaldehyde
Purity: >97.0%(GC)
Packaging: 5g
Price: $108
Updated: 2025/07/31

TRC

Product number: F401505
Product name: 5-Fluoro-2-methoxybenzaldehyde
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK612860
Product name: 5-Fluoro-2-methoxybenzaldehyde
Purity: 98%
Packaging: 1g
Price: $76
Updated: 2021/12/16

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5-FLUORO-2-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Pale yellow powder and lumps

Uses

5-Fluoro-2-methoxybenzaldehyde may be used in the synthesis of 5-(5-fluoro-2-methoxyphenyl)imidazolidine-2,4-dione.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 3145, 1988 DOI: 10.1021/jo00249a004
Synthetic Communications, 19, p. 2001, 1989 DOI: 10.1080/00397918908052593

General Description

5-Fluoro-2-methoxybenzaldehyde is an aryl fluorinated building block.

Synthesis

452-08-4

68-12-2

19415-51-1

Synthesis of compound 1.2. 2-Bromo-4-fluoroanisole (100 g, 487.75 mmol, 1.00 equiv) and THF (1.5 L) were added to a 3000 mL three-necked round-bottomed flask under nitrogen protection. With stirring at -78 °C, n-butyllithium (n-BuLi, 215.6 mL) was added slowly and dropwise. The reaction mixture was continued stirring at -78 °C for 1 hour. Subsequently, N,N-dimethylformamide (DMF, 71.54 g, 978.79 mmol, 2.01 eq.) was added slowly and dropwise at the same temperature. The reaction system was warmed up to room temperature and stirred for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of 800 mL of aqueous ammonium chloride (NH4Cl aq.). The reaction mixture was extracted with 500 mL of ethyl acetate, the organic layers were combined and concentrated under reduced pressure. The crude product was purified by column chromatography to afford 65.7 g (87% yield) of 5-fluoro-2-methoxybenzaldehyde (1.2) as a light yellow solid.

References

[1] Patent: WO2017/91600, 2017, A1. Location in patent: Paragraph 0386-0387
[2] Patent: US2017/166584, 2017, A1. Location in patent: Paragraph 0418-0420
[3] Journal of Organic Chemistry, 2013, vol. 78, # 12, p. 5955 - 5963

5-FLUORO-2-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-FLUORO-2-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 5-FLUORO-2-METHOXYBENZALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Fluoro-2-methoxybenzaldehyde 19415-51-1
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Career Henan Chemical Co

Product: 5-FLUORO-2-METHOXYBENZALDEHYDE 19415-51-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

19415-51-1, 5-FLUORO-2-METHOXYBENZALDEHYDERelated Search:

Methyl 5-fluoro-2-methyl-3-nitrobenzoate METHYL 2-METHYL-5-FLUOROBENZOATE 5-Fluoro-2-methylbenzoic acid 5-FLUORO-2-METHOXYBENZONITRILE 5-Fluoro-2-methoxyphenyl acetic acid 5-Fluoro-2-methoxyphenol 5-FLUORO-2-METHOXYACETOPHENONE 6-Fluoro-4-chromanone 5-FLUORO-2-METHOXYBENZALDEHYDE 2-Fluoro-3-methoxybenzaldehyde 96%,2-Fluoro-3-methoxybenzaldehyde96%,2-FLUORO-3-METHOXYBENZALDEHYDE 2-Fluoro-4-methoxybenzaldehyde97%,2-Fluoro-4-methoxybenzaldehyde 97%,2-FLUORO-4-METHOXYBENZALDEHYDE 4-(4-FLUOROBENZYLOXY)BENZALDEHYDE 3-CHLORO-5-FLUORO-4-METHOXYBENZALDEHYDE 6-CHLORO-2-FLUORO-3-METHOXYBENZALDEHYDE 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 3,5-Difluoro-4-methoxybenzaldehyde 6-FLUORO-2-METHYL-4-CHROMANONE 6-FLUORO-3-FORMYLCHROMONE

5-Fluoro-2-methoxybenzaldehyde,99%

5-FLUORO-2-METHOXYBEZALDEHYDE, 96%

5-Fluoro-o-2-methoxybenzaldehyde

5-Fluoro-o-methoxybenzaldehy

2-METHOXY-5-FLUOROBENZALDEHYDE

5-FLUORO-2-METHOXYBENZALDEHYDE

5-FLUORO-O-ANISALDEHYDE

5-Fluoro-2-methoxybenzaldehyde,5-Fluoro-o-anisaldehyde

4-Fluoro-2-formylanisole, 5-Fluoro-o-anisaldehyde

5-Fluoro-2-methoxybenzaldehyde 96%

5-Fluoro-<i>o</i>-anisaldehyde

Benzaldehyde,5-fluoro-2-methoxy-

5-Fluoro-o-anisaldehyde&gt

19415-51-1

Organic Building Blocks

Carbonyl Compounds

Building Blocks

Aldehydes

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Adehydes, Acetals & Ketones

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds