4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile

Product Name: 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile
CAS No.: 236750-65-5
Chemical Name: 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile
Synonyms: Erlotinib-12;Erlotinib Impurity W;Erlotinib interMediate;Erlotinib intermediates;Erlotinib impurities403;Azilsartan medoxomil impurity245;Erlotinib Hydrochloride iMpurity 16;Erlotinib Hydrochloride iMpurity 11;4,5-Bis(2-methoxy)-2-nitrobenzonitrile;4,5-Di(2-methoxyethoxy)-2-nitrobenzonitrile
CBNumber: CB52537927
Molecular Formula: C13H16N2O6
Formula Weight: 296.28
MOL File: 236750-65-5.mol

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4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Property

Boiling point:: 459.3±45.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B418920
Product name: 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile
Packaging: 250mg
Price: $40
Updated: 2021/12/16

TRC

Product number: B418920
Product name: 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile
Packaging: 1g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J56346
Product name: 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile
Packaging: 1g
Price: $25
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0389708
Product name: 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $505.59
Updated: 2021/12/16

Matrix Scientific

Product number: 096737
Product name: 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile
Purity: 95+%
Packaging: 250mg
Price: $515
Updated: 2021/12/16

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4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Chemical Properties,Usage,Production

Uses

4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile is an impurity of Erlotinib (E625008), a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.

Synthesis

80407-68-7

236750-65-5

The general procedure for the synthesis of 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile from 3,4-bis(2-methoxyethoxy)benzonitrile was as follows: 1) Nitration reaction: 200g of 3,4-bis(2-methoxyethoxy)benzonitrile was dissolved in 3L of glacial acetic acid to prepare feedstock I. Concentrated sulfuric acid and concentrated nitric acid were used as feedstock II and feedstock III, respectively. the flow rate was adjusted by a flow pump so that the flow rate of feedstock I was 20 ml/min, that of feedstock II was 10 ml/min, and that of feedstock III was 6 ml/min. the flow rate was adjusted by a flow pump so that the flow rate of feedstock II was 10 ml/min, and the flow rate of feedstock III was 6 ml/min. It was ensured that the molar ratio of HNO3 to 3,4-bis(2-methoxyethoxy)benzonitrile was 1:1.5, and the mass ratio of concentrated nitric acid to concentrated sulfuric acid was 1:4. The reaction temperature was set at 60 °C, and the reaction residence time was set at 60 seconds. The temperature of the cooling module was set to 20 °C. The reaction solution from the outlet of the cooling module was collected and the glacial acetic acid was recovered by distillation under reduced pressure. The residue was added to 1.2 L of water and extracted twice with 1 L of ethyl acetate. The organic phases were combined, washed to neutrality with saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate and evaporated. 215.21 g of 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile was obtained with 90.58% yield and 98.95% purity.

References

[1] Patent: CN108358798, 2018, A. Location in patent: Paragraph 0055; 0065; 0075; 0085; 0094-0099; 0102
[2] Patent: WO2007/138612, 2007, A2. Location in patent: Page/Page column 10
[3] Patent: WO2007/138613, 2007, A2. Location in patent: Page/Page column 11-12
[4] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 3, p. 909 - 914
[5] Heterocycles, 2007, vol. 71, # 1, p. 39 - 48

4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Preparation Products And Raw materials

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4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Suppliers

China 166 India 4 United States 8 Global 178

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View Lastest Price from 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile manufacturers

Sinoway Industrial co., ltd.

Product: 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile 236750-65-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2025-01-13

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile 236750-65-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-18

Nanjing Fred Technology Co., Ltd

Product: 4,5-Bis(2-methoxyethoxy)-2-nitro-benzonitrile 236750-65-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%(HPLC)
Supply Ability: 2000kg/Year
Release date: 2023-12-14

236750-65-5, 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrileRelated Search:

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4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile

Erlotinib interMediate

2-nitro-4,5-bis(2-Methoxyethoxy)benzonitrile

Erlotinib Hydrochloride iMpurity 11

Erlotinib Hydrochloride iMpurity 16

Erlotinib-12

4,5-Di(2-methoxyethoxy)-2-nitrobenzonitrile

Erlotinib Impurity W

Erlotinib intermediates

Benzonitrile, 4,5-bis(2-methoxyethoxy)-2-nitro-

4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile USP/EP/BP

Azilsartan medoxomil impurity245

Erlotinib impurities403

4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile 236750-65-5

4,5-Bis(2-methoxy)-2-nitrobenzonitrile

2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile(Erlotinib intermediate)

2-Nitro-4,5-di - (2-methoxyethoxy) benzonitrile (intermediate of erlotinib)

236750-65-5