4-HYDROXYINDAZOLE

Uses

Product Name: 4-HYDROXYINDAZOLE
CAS No.: 81382-45-8
Chemical Name: 4-HYDROXYINDAZOLE
Synonyms: 1H-Indazol-4-ol;4-HYDROXYINDAZOLE;1H-Indazol-4-ol ,97%;4-Hydroxy-1H-indazole;4-Hydroxyindazole HCl;4-HYDROXYL (1H)INDAZOLE;4-Hydroxyindazole hydrochloride;1,2-dihydroindazol-4-one hydrochloride
CBNumber: CB5254031
Molecular Formula: C7H6N2O
Formula Weight: 134.14
MOL File: 81382-45-8.mol

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4-HYDROXYINDAZOLE Property

Melting point:: 177-178℃
Boiling point:: 366.5±15.0 °C(Predicted)
Density: 1.434±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.76±0.40(Predicted)
Appearance: Light yellow to green yellow Solid

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Safety

Risk Statements: 20/21/22
Safety Statements: 24/25-36/37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: A416355
Product name: 4-Hydroxyindazole
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A416355
Product name: 4-Hydroxyindazole
Packaging: 1g
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: Y5565
Product name: 1H-Indazol-4-ol
Packaging: 1g
Price: $197
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK113408
Product name: 1H-Indazol-4-ol
Purity: 97%
Packaging: 1g
Price: $231
Updated: 2021/12/16

Matrix Scientific

Product number: 069755
Product name: 4-Hydroxy-1H-indazole
Purity: 95%
Packaging: 5g
Price: $1464
Updated: 2021/12/16

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4-HYDROXYINDAZOLE Chemical Properties,Usage,Production

Uses

4-Hydroxyinazole is a heterocyclic compound mainly used in laboratory organic synthesis and chemical production processes.

Chemical Properties

White to off-white solid

Synthesis

41748-71-4

81382-45-8

C. General procedure for the preparation of 4-hydroxyindazole from 4-aminoindazole: 4-aminoindazole (9.6 g, 0.072 mol) was dissolved in a glass reaction vessel containing 7.2 g of concentrated sulfuric acid in 75 mL of water. The mixture was transferred to a stainless steel autoclave, sealed and heated to 170°C for overnight reaction. Upon completion of the reaction, a large amount of black precipitate appeared in the reaction mixture. The reaction mixture was diluted with ethyl acetate and water and transferred to a dispensing funnel for distribution. The aqueous layer was extracted with ethyl acetate several times until 4-hydroxyindazole was completely transferred to the organic phase. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give a dark brown or black oil. The crude product was purified by silica gel column chromatography with an eluent of 50% ethyl acetate/hexane mixture to give 4-hydroxyindazole as an off-white solid (3.3 g, 33% yield).

References

[1] Patent: WO2004/39796, 2004, A1. Location in patent: Page/Page column 71-72
[2] Patent: US6534504, 2003, B1
[3] Patent: US6841563, 2005, B1. Location in patent: Page column 20
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 8, p. 3975 - 3991
[5] Journal of the Chemical Society, 1955, p. 2412,2419

4-HYDROXYINDAZOLE Preparation Products And Raw materials

Raw materials

2-Methyl-3-nitroaniline Palladium Sodium nitrite Acetic acid Methanol Sulfuric acid

Preparation Products

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4-HYDROXYINDAZOLE Suppliers

China 83 India 2 United Kingdom 2 United States 13 Global 100

Accela ChemBio Inc.

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View Lastest Price from 4-HYDROXYINDAZOLE manufacturers

Career Henan Chemical Co

Product: 4-Hydroxyindazole 81382-45-8
Price: US $1.00/g
Min. Order: 1g
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-09

81382-45-8, 4-HYDROXYINDAZOLERelated Search:

4-Methoxyindazole-3-carboxylic acid 4-HYDROXYINDAZOLE 4,6-DIHYDROXY-1H-INDAZOLE 3-CHLORO-6-FLUORO-4-METHOXYINDAZOLE 6-AMINO-4-HYDROXY-1H-INDAZOLE 3-BROMO-6-CHLORO-4-HYDROXYINDAZOLE 6-CHLORO-4-METHOXY-3-(1H)INDAZOLE CARBOXYLIC ACID 3,6-DICHLORO-4-METHOXYINDAZOLE 6-CHLORO-4-HYDROXY-3-IODO (1H)INDAZOLE 6-BROMO-4-HYDROXY-3-CHLORO (1H)INDAZOLE METHYL 4-METHOXY-1H-INDAZOLE-3-CARBOXYLATE 6-CHLORO-4-METHOXY-3-(1H)INDAZOLE CARBOXALDEHYDE 4-HYDROXY-1H-INDAZOLE-3-CARBOXYLIC ACID 6-BROMO-4-METHOXY-1H-INDAZOLE 3-CHLORO-6-FLUORO-4-HYDROXYINDAZOLE 4-(BENZYLOXY)-1H-INDAZOLE 6-CHLORO-4-METHOXY-1H-INDAZOLE 6-CHLORO-4-METHOXY-3-IODO-1H-INDAZOLE

4-HYDROXYINDAZOLE

4-Hydroxyindazole HCl

4-HYDROXYL (1H)INDAZOLE

1H-Indazol-4-ol ,97%

4-Hydroxy-1H-indazole

1H-Indazol-4-ol

4-Hydroxyindazole hydrochloride

1,2-dihydroindazol-4-one hydrochloride

81382-45-8

pharmacetical