ChemicalBook > CAS DataBase List > PF-04929113

PF-04929113

Product Name: PF-04929113
CAS No.: 908115-27-5
Chemical Name: PF-04929113
Synonyms: CS-33;SN-5422;snx54227;SNX-5422;SNX-5542;SC-102112;SC-105422;SC-107881;PF-4928473;PF-4929113
CBNumber: CB52561489
Molecular Formula: C25H30F3N5O4
Formula Weight: 521.53
MOL File: 908115-27-5.mol

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PF-04929113 Property

Melting point:: 298-299℃
Boiling point:: 646.5±55.0 °C(Predicted)
Density: 1.48
storage temp.: Store at -20°C
solubility: ≥23.85 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form: solid
pka: 15.07±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18270
Product name: PF-04929113
Purity: ≥98%
Packaging: 1mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 18270
Product name: PF-04929113
Purity: ≥98%
Packaging: 5mg
Price: $248
Updated: 2024/03/01

Cayman Chemical

Product number: 18270
Product name: PF-04929113
Purity: ≥98%
Packaging: 10mg
Price: $440
Updated: 2024/03/01

Cayman Chemical

Product number: 18270
Product name: PF-04929113
Purity: ≥98%
Packaging: 25mg
Price: $963
Updated: 2024/03/01

TRC

Product number: P293780
Product name: PF04929113
Packaging: 10mg
Price: $495
Updated: 2021/12/16

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PF-04929113 Chemical Properties,Usage,Production

Uses

PF 04929113 can be used in pharmacological activity and therapeutic use in therapeutic breast cancer drug target for multiclass comparative virtual screening to identify novel Hsp90 inhibitors. HSP90

Biological Activity

pf-04929113 is an inhibitor of hsp90 [1].pf-04929113 is a water soluble and orally bioavailable prodrug of pf-04928473. it is rapidly absorbed and converted into pf-04928473 after oral administration. in mice bearing bt-474 tumor xenografts, treatment of pf-04928473 causes the degradation of the her2 client protein. and no obvious toxicity is observed when the dose of pf-04928473 is up to 150mg/kg. treatment of 100mg/kg pf-04928473 results in complete tumor growth inhibition and in some mice partial tumor regressions. pf-04928473 also shows significant antitumor activity in mice with h1650 xenografts. in addition, as an inhibitor of hsp90, pf-04928473 is reported to inhibit p-erk and p-akt, decrease cd31+ cells and mvd as well as a have an effect on angiogenesis in vivo [1, 2].

Enzyme inhibitor

This potent and selective HSP90 inhibitor (FW = 521.54 g/mol; CAS 908115-27-5; Solubility: 100 mg/mL DMSO, <1mg/mL H2O), also knownas SNX-5422 and (1R,4R)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3- (trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2- aminoacetate, targets heat shock protein-90 (Kd = 41 nM) and also inhibits Her-2 degradation (IC50 = 37 nM). PF-04929113 also shows potent antiproliferative activity against a broad range of cancer cell types, e.g. MCF-7 (IC50 =16 nM), SW620 (IC50 =19 nM), K562 (IC50 =23 nM), SK-MEL-5 (IC50 =25 nM), and A375 (IC50 =51 nM). SNX2112 inhibits in vitro proliferation, inducing G2/M arrest, and enhanced cytotoxicity, chemosensitivity, and radiosensitivity between 25 and 250 nM, decreasing expression and/or phosphorylation of EGFR, c-MET, AKT, ERK-1 and -2, IκB kinase, and STAT3, corresponding downstream NFκB, AP-1, and STAT3 reporter genes, and target oncogenes and angiogenic cytokines.

in vivo

SNX-5422 (50 mg/kg, p.o.) efficiently inhibits tumor growth of HT-29 human colon tumor xenograft model after administration 3 times a week for 3 weeks (qod×3/2×3)^[1]. SNX-5422 (20, 40 mg/kg, p.o.) markedly inhibits multiple myeloma (MM) tumor growth and angiogenesis in mice^[2].

target

Hsp90

References

[1] chandarlapaty s, sawai a, ye q, scott a, silinski m, huang k, fadden p, partdrige j, hall s, steed p, norton l, rosen n, solit db. snx2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against her kinase-dependent cancers. clin cancer res. 2008 jan 1;14(1):240-8.
[2] okawa y, hideshima t, steed p, vallet s, hall s, huang k, rice j, barabasz a, foley b, ikeda h, raje n, kiziltepe t, yasui h, enatsu s, anderson kc. snx-2112, a selective hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via akt and erk. blood. 2009 jan 22;113(4):846-55.

PF-04929113 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-04929113 Suppliers

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908115-27-5, PF-04929113Related Search:

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea 1 NM-PP1 BLU 9931 ZLN005 Esomeprazole magnesium Tariquidar Palbociclib IXABEPILONE L-4-THIAZOLYLALANINE Ilomastat AZD-1208 Crenolanib Doxorubicin hydrochloride Selumetinib BIIB-021 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide Quizartinib (AC220) Fingolimod hydrochloride

CS-33

SNX5422;PF 04929113;SNX 5422;PF-04929113;

(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate

(1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate

PF-04929113, >=98%

snx54227

PF04929113 SNX-54227

PF-04929113

SNX-5422

PF-04929113(SNX5422)

Glycine trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester

trans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate

snx5422 PF 04929113

PF-04929113 USP/EP/BP

trans-4-((2-Carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate

PF-04929113 SNX-5422 PF04929113 SNX5422

PF04929113, 10 mM in DMSO

PF-4928473

PF-4929113

SC-102112

SC-105422

SC-107881

SN-5422

SNX-5542

908115-27-5

C25H30F3N5O4

Inhibitors

Inhibitor