ChemicalBook > CAS DataBase List > 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER

2-BROMOPROPIONIC ACID TERT-BUTYL ESTER

Product Name
2-BROMOPROPIONIC ACID TERT-BUTYL ESTER
CAS No.
39149-80-9
Chemical Name
2-BROMOPROPIONIC ACID TERT-BUTYL ESTER
Synonyms
t-Butyl 2-Bromopropionate;ert-butyl2-bromopropanoate;tert-butyl 2-broMopropanoate;Bromopropionicacidbutylester;TERT-BUTYL 2-BROMOPROPIONATE;tert-Butyl2-Bromopropionate>BROMOPROPIONIC ACID TERT-BUTYL ESTER;tert-butyl 2-bromopropionate, 97%min;2-Bromo propionic acid tert buty ester;2-BROMOPROPIONIC ACID TERT-BUTYL ESTER
CBNumber
CB5257678
Molecular Formula
C7H13BrO2
Formula Weight
209.08
MOL File
39149-80-9.mol
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2-BROMOPROPIONIC ACID TERT-BUTYL ESTER Property

Boiling point:
90 °C / 60mmHg
Density 
1,26 g/cm3
refractive index 
1.4380-1.4410
storage temp. 
Inert atmosphere,2-8°C
form 
clear liquid
color 
Colorless to Light yellow to Light orange
InChI
InChI=1S/C7H13BrO2/c1-5(8)6(9)10-7(2,3)4/h5H,1-4H3
InChIKey
CVAWKJKISIPBOD-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)C(Br)C
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Safety

Risk Statements 
10-36/37/38
Safety Statements 
16-26-36
RIDADR 
3272
HS Code 
2915.50.5000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B1277
Product name
tert-Butyl 2-Bromopropionate
Purity
>97.0%(GC)
Packaging
25g
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
B1277
Product name
tert-Butyl 2-Bromopropionate
Purity
>97.0%(GC)
Packaging
500g
Price
$664
Updated
2025/07/31
TRC
Product number
B692760
Product name
tert-Butyl2-Bromopropanoate
Packaging
10g
Price
$130
Updated
2021/12/16
Oakwood
Product number
115400
Product name
tert-Butyl 2-Bromopropionate
Purity
97%
Packaging
1g
Price
$20
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB75146
Product name
2-Bromopropionic acid tert-butyl ester
Packaging
10g
Price
$60
Updated
2021/12/16
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2-BROMOPROPIONIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

tert-Butyl 2-Bromopropanoate is a reactant used in the synthesis 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as cytosolic phospholipase A2α inhibitors.

Synthesis Reference(s)

Tetrahedron Letters, 13, p. 4067, 1972 DOI: 10.1016/S0040-4039(01)94239-X

Synthesis

598-72-1

115-11-7

39149-80-9

Step 1 Synthesis of tert-butyl 2-bromopropionate. Isobutene (2.4 g, 42.8 mmol) was condensed into a pressurized reaction flask at -15 °C. Dioxane (6 mL) and 2-bromopropionic acid (3.5 mL, 38.9 mmol) were then added and the mixture was stirred for 5 minutes. After slow warming to -10°C, concentrated sulfuric acid (250 μL) was added dropwise. The reaction vial was sealed and the reaction mixture was stirred at room temperature overnight. After the reaction was completed, the reaction vial was opened and the reaction mixture was poured into dichloromethane (50 mL). The organic phase was washed sequentially with 20% potassium carbonate solution (50 mL) and water (50 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give tert-butyl 2-bromopropionate (2.17 g, 27% yield). The product was characterized by 1H NMR (CDCl3, δ): 4.31 (1H, q, J=7.1Hz), 1.81 (3H, d, J=7.1Hz), 1.52 (9H, s).

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 784 - 796
[2] Canadian Journal of Chemistry, 2003, vol. 81, # 8, p. 915 - 936
[3] Patent: US6399600, 2002, B1
[4] Journal fuer Praktische Chemie (Leipzig), 1974, vol. 316, p. 729 - 740
[5] Bulletin de la Societe Chimique de France, 1974, p. 2985 - 2986

2-BROMOPROPIONIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMOPROPIONIC ACID TERT-BUTYL ESTER Suppliers

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View Lastest Price from 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Bromopropionic acid tert-butyl ester 39149-80-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
2-BROMOPROPIONIC ACID TERT-BUTYL ESTER 39149-80-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-22

39149-80-9, 2-BROMOPROPIONIC ACID TERT-BUTYL ESTERRelated Search:

tert-Butyl 2-bromo-2-methylpropanoate Butyl propionate T-BUTYL 3-BROMOPROPIONATE 97 tert-Butyl bromoacetate (S)-(-)-2-BROMOPROPIONIC ACID 2-Bromopropionic acid TERT-BUTYL PROPIONATE 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER TERT-BUTYL 2-BROMOBUTYRATE 1-BROMO-CYCLOHEXANECARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 2,4-DIBROMOBUTYRATE

  • 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER 97+%
  • tert-butyl 2-broMopropanoate
  • 2-bromopropanoic acid tert-butyl ester
  • Bromopropionicacidbutylester
  • 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER
  • TERT-BUTYL 2-BROMOPROPIONATE
  • t-Butyl 2-Bromopropionate
  • tert-Butyl2-Bromopropionate&gt
  • Propanoic acid, 2-bromo-, 1,1-dimethylethyl ester
  • ert-butyl2-bromopropanoate
  • 2-Bromo propionic acid tert buty ester
  • BROMOPROPIONIC ACID TERT-BUTYL ESTER
  • tert-butyl 2-bromopropionate, 97%min
  • 39149-80-9
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