2-BROMOPROPIONIC ACID TERT-BUTYL ESTER
- Product Name
- 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER
- CAS No.
- 39149-80-9
- Chemical Name
- 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER
- Synonyms
- t-Butyl 2-Bromopropionate;ert-butyl2-bromopropanoate;tert-butyl 2-broMopropanoate;Bromopropionicacidbutylester;TERT-BUTYL 2-BROMOPROPIONATE;tert-Butyl2-Bromopropionate>BROMOPROPIONIC ACID TERT-BUTYL ESTER;tert-butyl 2-bromopropionate, 97%min;2-Bromo propionic acid tert buty ester;2-BROMOPROPIONIC ACID TERT-BUTYL ESTER
- CBNumber
- CB5257678
- Molecular Formula
- C7H13BrO2
- Formula Weight
- 209.08
- MOL File
- 39149-80-9.mol
2-BROMOPROPIONIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 90 °C / 60mmHg
- Density
- 1,26 g/cm3
- refractive index
- 1.4380-1.4410
- storage temp.
- Inert atmosphere,2-8°C
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C7H13BrO2/c1-5(8)6(9)10-7(2,3)4/h5H,1-4H3
- InChIKey
- CVAWKJKISIPBOD-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)C(Br)C
Safety
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- 3272
- HS Code
- 2915.50.5000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B1277
- Product name
- tert-Butyl 2-Bromopropionate
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $67
- Updated
- 2025/07/31
- Product number
- B1277
- Product name
- tert-Butyl 2-Bromopropionate
- Purity
- >97.0%(GC)
- Packaging
- 500g
- Price
- $664
- Updated
- 2025/07/31
- Product number
- B692760
- Product name
- tert-Butyl2-Bromopropanoate
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 115400
- Product name
- tert-Butyl 2-Bromopropionate
- Purity
- 97%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- FB75146
- Product name
- 2-Bromopropionic acid tert-butyl ester
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
2-BROMOPROPIONIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Uses
tert-Butyl 2-Bromopropanoate is a reactant used in the synthesis 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as cytosolic phospholipase A2α inhibitors.
Synthesis Reference(s)
Tetrahedron Letters, 13, p. 4067, 1972 DOI: 10.1016/S0040-4039(01)94239-X
Synthesis
598-72-1
115-11-7
39149-80-9
Step 1 Synthesis of tert-butyl 2-bromopropionate. Isobutene (2.4 g, 42.8 mmol) was condensed into a pressurized reaction flask at -15 °C. Dioxane (6 mL) and 2-bromopropionic acid (3.5 mL, 38.9 mmol) were then added and the mixture was stirred for 5 minutes. After slow warming to -10°C, concentrated sulfuric acid (250 μL) was added dropwise. The reaction vial was sealed and the reaction mixture was stirred at room temperature overnight. After the reaction was completed, the reaction vial was opened and the reaction mixture was poured into dichloromethane (50 mL). The organic phase was washed sequentially with 20% potassium carbonate solution (50 mL) and water (50 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give tert-butyl 2-bromopropionate (2.17 g, 27% yield). The product was characterized by 1H NMR (CDCl3, δ): 4.31 (1H, q, J=7.1Hz), 1.81 (3H, d, J=7.1Hz), 1.52 (9H, s).
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 784 - 796
[2] Canadian Journal of Chemistry, 2003, vol. 81, # 8, p. 915 - 936
[3] Patent: US6399600, 2002, B1
[4] Journal fuer Praktische Chemie (Leipzig), 1974, vol. 316, p. 729 - 740
[5] Bulletin de la Societe Chimique de France, 1974, p. 2985 - 2986
2-BROMOPROPIONIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-BROMOPROPIONIC ACID TERT-BUTYL ESTER Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER manufacturers
- Product
- 2-Bromopropionic acid tert-butyl ester 39149-80-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 2-BROMOPROPIONIC ACID TERT-BUTYL ESTER 39149-80-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-22