BAY 80-6946 (Copanlisib)

Binding Mode

Product Name: BAY 80-6946 (Copanlisib)
CAS No.: 1032568-63-0
Chemical Name: BAY 80-6946 (Copanlisib)
Synonyms: Copanlisib;BAY80-6946;CS-2321;Aliqopa);Copanlisib base;Copanlisib free base;Copanlisib(BAY80-6946);BAY 80-6946 (BAY80-6946;BAY 80-6946 (Copanlisib);BAY 80-6946 (Copanlisib) USP/EP/BP
CBNumber: CB52616024
Molecular Formula: C23H28N8O4
Formula Weight: 480.52
MOL File: 1032568-63-0.mol

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BAY 80-6946 (Copanlisib) Property

Density: 1.51
storage temp.: Store at -20°C
solubility: insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 8.42±0.20(Predicted)
color: Off-white to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20354
Product name: Copanlisib
Purity: ≥98%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 20354
Product name: Copanlisib
Purity: ≥98%
Packaging: 1mg
Price: $72
Updated: 2023/06/20

Cayman Chemical

Product number: 20354
Product name: Copanlisib
Purity: ≥98%
Packaging: 10mg
Price: $91
Updated: 2024/03/01

TRC

Product number: B119060
Product name: BAY80-6946
Packaging: 10mg
Price: $395
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BC164810
Product name: Copanlisib
Packaging: 25mg
Price: $450
Updated: 2021/12/16

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BAY 80-6946 (Copanlisib) Chemical Properties,Usage,Production

Binding Mode

As shown in the co-crystal structure of copanlisib bound to PI3Kγ, the inhibitor binds with only one critical hydrogen bond to the amide NH of Val882 in the adenine pocket, employing the imidazoline N1 nitrogen (Figs. 1 and 2). In addition, the C5 aminopyrimidine group fills the affinity pocket, forming hydrogen bonds with two carboxylic residues of Asp836 and Asp841 through the amino group. Finally, the solvent exposed morpholine lies over Trp812, presumably providing additional attractive molecular contacts.

Uses

BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models.

Definition

ChEBI: Copanlisib is an imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of morpholines, an aromatic ether, a diether, a tertiary amino compound, a secondary carboxamide, a pyrimidinecarboxamide, an aminopyrimidine and an imidazoquinazoline.

brand name

Aliqopa

General Description

Class: lipid kinase; Treatment: FL (IV infusion); Other name: BAY 80-6946; Elimination half-life = 52 h (IV); Protein binding = 84.2%

Pharmacokinetics

Copanlisib has poor oral bioavailability due to low permeability and poor solubility, and therefore, it is not suitable for an oral medication. Consequently, it was developed as an IV drug. IV infusion of copanlisib resulted in rapid distribution throughout the body and a prolonged elimination half-life (52 h).

target

pan-PI3K

Metabolism

Copanlisib was the predominant component in human plasma, accounting for 84% of total radioactivity AUC, and the morpholinone metabolite 6 was the only circulating metabolite (about 5%).

BAY 80-6946 (Copanlisib) Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY 80-6946 (Copanlisib) Suppliers

China 126 India 5 United States 17 Global 148

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View Lastest Price from BAY 80-6946 (Copanlisib) manufacturers

Career Henan Chemical Co

Product: BAY 80-6946 (Copanlisib) 1032568-63-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1032568-63-0, BAY 80-6946 (Copanlisib)Related Search:

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BAY 80-6946 (Copanlisib)

7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

BAY80-6946

2-Amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]-5-pyrimidinecarboxamide

Copanlisib

5-Pyrimidinecarboxamide, 2-amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]-

Copanlisib(BAY80-6946)

Copanlisib, 98%, an ATP-competitive selective class-I PI3 kinases inhibitor

Copanlisib base

BAY 80-6946 (BAY80-6946

CS-2321

BAY 80-6946; BAY80-6946; BAY-80-6946; BAY806946; BAY-806946; BAY 806946; COPANLISIB FREE BASE

Copanlisib free base

BAY 80-6946 (Copanlisib) USP/EP/BP

Aliqopa)

2-Amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide

1032568-63-0

C23H28N8O4

Inhibitors

Akt

mTOR

PI3K

PI3K/Akt/mTOR