Salirasib
- Product Name
- Salirasib
- CAS No.
- 162520-00-5
- Chemical Name
- Salirasib
- Synonyms
- FTS;irasib;CS-1744;Salirasib;Unii-mzh0om550m;Salirasib USP/EP/BP;Farnesylthiosalicylate;FARNESYLTHIOSALICYLIC ACID;S-Farnesylthiosalicylic acid;Salirasib(S-Farnesylthiosalicylic aci)
- CBNumber
- CB9694198
- Molecular Formula
- C22H30O2S
- Formula Weight
- 358.54
- MOL File
- 162520-00-5.mol
Salirasib Property
- Melting point:
- 64-66°C
- Boiling point:
- 486.0±45.0 °C(Predicted)
- Density
- 1.05
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 3.50±0.36(Predicted)
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety
- HS Code
- 2930.90.2900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- SML1166
- Product name
- Salirasib
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $51.3
- Updated
- 2024/03/01
- Product number
- SML1166
- Product name
- Salirasib
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $347
- Updated
- 2024/03/01
- Product number
- A3351
- Product name
- Salirasib
- Packaging
- 25MG
- Price
- $181
- Updated
- 2024/03/01
- Product number
- A3351
- Product name
- Salirasib
- Packaging
- 100MG
- Price
- $500
- Updated
- 2024/03/01
- Product number
- 10010501
- Product name
- Farnesyl Thiosalicylic Acid
- Purity
- ≥96%
- Packaging
- 5mg
- Price
- $40
- Updated
- 2024/03/01
Salirasib Chemical Properties,Usage,Production
Description
Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-
Chemical Properties
Pale Yellow Solid
Uses
It is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.
Uses
Salirasib is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.
Uses
Salirasib has been used as a farnesyltransferase inhibitor.
Definition
ChEBI: Salirasib is a sesquiterpenoid.
Biochem/physiol Actions
Salirasib (Farnesylthiosalicylic acid) is a RAS inhibitor that acts by dislodging the farnesylated protein from the membrane, facilitating Ras degradation. Salirasib impairs downstream signaling and suppresses growth and migration of proliferating tumor cells in in vitro and in vivo models. Salirasib (Farnesylthiosalicylic acid) has recently been shown to possess significant anti-inflammatory and anti-arthritic properties.
References
1) Marciano?et al. (1995),?Farnesyl Derivatives of Rigid Carboxylic Acids – Inhibitors of ras-Dependent Cell Growth; J. Med. Chem.,?38?1267 2) Marom?et al. (1995),?Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid (salirasib) in patients with solid tumors; J. Biol. Chem.,?270?22263 3) Haklai?et al. (1998),?Dislodgement and Accelerated Degradation of Ras; Biochemistry,?37?1306 4) Laheru?et al. (2012),?Integrated preclinical and clinical development of S-trans,trans-Farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer; Invest .New Drugs,?30?2391 5) Tsimberidou?et al. (2010),?Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors; Cancer Chemother. Pharmacol.,?65?235 6) Charette?et al. (2013),?Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms; Cell Death and Disease.?4?e471 7) Maher?et al. (2008),?Activation of TRPA1 by farnesyl thiosalicylic acid; Mol. Pharmacol.,?73?1225
Salirasib Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Salirasib manufacturers
- Product
- Salirasib 162520-00-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Salirasib 162520-00-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Salirasib 162520-00-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20