Salirasib

ChemicalBook > CAS DataBase List > Salirasib

Product Name: Salirasib
CAS No.: 162520-00-5
Chemical Name: Salirasib
Synonyms: FTS;irasib;CS-1744;Salirasib;Unii-mzh0om550m;Salirasib USP/EP/BP;Farnesylthiosalicylate;FARNESYLTHIOSALICYLIC ACID;S-Farnesylthiosalicylic acid;Salirasib(S-Farnesylthiosalicylic aci)
CBNumber: CB9694198
Molecular Formula: C22H30O2S
Formula Weight: 358.54
MOL File: 162520-00-5.mol

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Salirasib Property

Melting point:: 64-66°C
Boiling point:: 486.0±45.0 °C(Predicted)
Density: 1.05
storage temp.: -20°C
solubility: DMSO: soluble20mg/mL, clear
pka: 3.50±0.36(Predicted)
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

HS Code: 2930.90.2900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1166
Product name: Salirasib
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $51.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1166
Product name: Salirasib
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $347
Updated: 2024/03/01

TCI Chemical

Product number: A3351
Product name: Salirasib
Packaging: 25MG
Price: $181
Updated: 2024/03/01

TCI Chemical

Product number: A3351
Product name: Salirasib
Packaging: 100MG
Price: $500
Updated: 2024/03/01

Cayman Chemical

Product number: 10010501
Product name: Farnesyl Thiosalicylic Acid
Purity: ≥96%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

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Salirasib Chemical Properties,Usage,Production

Description

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC₅₀ value of 7.5 μM. It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase (PPMTase) in cell-free systems with a K_i value of 2.6 μM, it is relatively ineffective at inhibiting methylation in whole cells. Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.

Chemical Properties

Pale Yellow Solid

Uses

It is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.

Uses

Salirasib is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.

Uses

Salirasib has been used as a farnesyltransferase inhibitor.

Definition

ChEBI: Salirasib is a sesquiterpenoid.

Biochem/physiol Actions

Salirasib (Farnesylthiosalicylic acid) is a RAS inhibitor that acts by dislodging the farnesylated protein from the membrane, facilitating Ras degradation. Salirasib impairs downstream signaling and suppresses growth and migration of proliferating tumor cells in in vitro and in vivo models. Salirasib (Farnesylthiosalicylic acid) has recently been shown to possess significant anti-inflammatory and anti-arthritic properties.

References

1) Marciano?et al. (1995),?Farnesyl Derivatives of Rigid Carboxylic Acids – Inhibitors of ras-Dependent Cell Growth; J. Med. Chem.,?38?1267 2) Marom?et al. (1995),?Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid (salirasib) in patients with solid tumors; J. Biol. Chem.,?270?22263 3) Haklai?et al. (1998),?Dislodgement and Accelerated Degradation of Ras; Biochemistry,?37?1306 4) Laheru?et al. (2012),?Integrated preclinical and clinical development of S-trans,trans-Farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer; Invest .New Drugs,?30?2391 5) Tsimberidou?et al. (2010),?Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors; Cancer Chemother. Pharmacol.,?65?235 6) Charette?et al. (2013),?Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms; Cell Death and Disease.?4?e471 7) Maher?et al. (2008),?Activation of TRPA1 by farnesyl thiosalicylic acid; Mol. Pharmacol.,?73?1225

Salirasib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Salirasib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Salirasib 162520-00-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Salirasib 162520-00-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: Salirasib 162520-00-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

162520-00-5, SalirasibRelated Search:

TYRPHOSTIN AG 1296 Imatinib mesylate AG 490 (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Gefitinib U0126-EtOH SB 202190 ABT 737 Crizotinib Rapamycin Thiobenzoic acid Salirasib (E)-3,7-Dimethylocta-2,6-diene-1-thiol (3-METHYL-BUT-2-ENYLSULFANYL)-BENZENE

2-(((2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl)thio)benzoicacid

CS-1744

Salirasib(S-Farnesylthiosalicylic aci)

FARNESYLTHIOSALICYLIC ACID

FTS

Unii-mzh0om550m

(3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL)-2-THIOBENZOIC ACID

2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid

Farnesylthiosalicylate

Salirasib

S-Farnesylthiosalicylic acid

(E,E)-2-[(3,7,11-TriMethyl-2,6,10-dodecatrienyl)thio]benzoic Acid

S-trans,trans-Farnesylthiosalicylic acid

2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoic acid

irasib

Benzoic acid, 2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-

Salirasib USP/EP/BP

Salirasib (Farnesyl Thiosalicylic Acid)

162520-00-5

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