PCI 34051
- Product Name
- PCI 34051
- CAS No.
- 950762-95-5
- Chemical Name
- PCI 34051
- Synonyms
- PCI-34051;PCI 34051;PCI-34051;PCI 34051;N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-
- CBNumber
- CB52622953
- Molecular Formula
- C17H16N2O3
- Formula Weight
- 296.32
- MOL File
- 950762-95-5.mol
PCI 34051 Property
- Density
- 1.25
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO
- form
- Powder
- pka
- 9.16±0.30(Predicted)
- color
- White to gray
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10444
- Product name
- PCI 34051
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 10444
- Product name
- PCI 34051
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 10444
- Product name
- PCI 34051
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $602
- Updated
- 2024/03/01
- Product number
- 10444
- Product name
- PCI 34051
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $829
- Updated
- 2024/03/01
- Product number
- 4643
- Product name
- PCI34051
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $471
- Updated
- 2021/12/16
PCI 34051 Chemical Properties,Usage,Production
Uses
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
Definition
ChEBI: N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide is an indolecarboxamide.
Biological Activity
pci-34051 is a potent, specific inhibitor of histone deacetylase 8 (hdac8) with greater than 200-fold selectivity over the other hdac isoforms, such as 1, 2, 3, 6 and 10. it induces caspase dependent apoptosis in cell lines derived from t-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. pci-34051 does not cause detectable histone or tubulin acetylation and also does not inhibit growth or induce apoptosis in normal cells such as pbmcs or fibroblasts. although a phospholipase c-gamma1 (plcgamma1) defective line is resistant, cells defective in t-cell receptor signaling are still sensitive to pci-34051 induced apoptosis.
storage
-20°C
PCI 34051 Preparation Products And Raw materials
Raw materials
Preparation Products
PCI 34051 Suppliers
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- +1-832-696-8203
- Fax
- +1-832-641-3177
- info@apexbt.com
- Country
- United States
- ProdList
- 477
- Advantage
- 60
- Tel
- 857-239-0968
- Fax
- 857-239-8801
- service1@targetmol.com
- Country
- United States
- ProdList
- 2559
- Advantage
- 60
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4660
- Advantage
- 60
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32165
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
- ProdList
- 2738
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38632
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@apexbt.com
- Country
- United States
- ProdList
- 6251
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- United States
- ProdList
- 6773
- Advantage
- 87
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80
- Tel
- --
- Fax
- --
- info@creative-enzymes.com
- Country
- United States
- ProdList
- 6057
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@axonmedchem.com
- Country
- United States
- ProdList
- 763
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@matrixscientific.com
- Country
- United States
- ProdList
- 6632
- Advantage
- 80
- Tel
- --
- Fax
- --
- info@selleckchem.com
- Country
- United States
- ProdList
- 824
- Advantage
- 60
- Tel
- --
- Fax
- --
- scbt@scbt.com
- Country
- United States
- ProdList
- 3597
- Advantage
- 60
View Lastest Price from PCI 34051 manufacturers
- Product
- N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide 950762-95-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23
- Product
- N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide 950762-95-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-20