Regorafenib (Hydrochloride)

Product Name: Regorafenib (Hydrochloride)
CAS No.: 835621-07-3
Chemical Name: Regorafenib (Hydrochloride)
Synonyms: Regofini;Regorafenib HC;Regafenib HCL;Regorafenib HCl;Regafenib hydrochloride;BAY73-4506 hydrochloride;egorafenib (Hydrochloride);5-Diiodotyrosine Dihydrate;Regorafenib (Hydrochloride);Regorafenib HCl (BAY-73-4506)
CBNumber: CB52624290
Molecular Formula: C21H16Cl2F4N4O3
Formula Weight: 519.2763528
MOL File: 835621-07-3.mol

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Regorafenib (Hydrochloride) Property

storage temp.: Store at -20°C
solubility: ≥ 25.95 mg/mL in DMSO, ≥ 8.75 mg/mL in EtOH with ultrasonic and warming
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0725
Product name: Regorafenib(Hydrochloride)
Purity: 99.58%
Packaging: 50mg
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: A3750
Product name: Regorafenibhydrochloride
Packaging: 10mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-0725
Product name: Regorafenib(Hydrochloride)
Purity: 99.58%
Packaging: 100mg
Price: $80
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001550
Product name: REGORAFENIB HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $154
Updated: 2021/12/16

AK Scientific

Product number: 4001AH
Product name: Regorafenibhydrochloride
Packaging: 5mg
Price: $186
Updated: 2021/12/16

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Regorafenib (Hydrochloride) Chemical Properties,Usage,Production

Uses

BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

in vitro

Regorafenib potently inhibits VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with an IC50 of 3 nM. In HAoSMCs, regorafenib inhibits PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of 3 nMf. Regorafenib causes a concentration-dependent decrease in Hep3B cell growth, having an IC50 of 5 μM. Regorafenib subsequently increases the levels of phospho-c-Jun, a JNK target, but not total c-Jun in Hep3B cells.

in vivo

Regorafenib effectively inhibits growth of the Colo-205 xenografts in the dose range of 10-100 mg/kg reaching a TGI of 75% at day 14 at the 10 mg/kg dose. In the MDA-MB-231 model, regorafenib is highly efficacious at a dose as low as 3 mg/kg, resulting in a significant TGI of 81%, which increases to 93% at doses of 10 and 30 mg/kg, where tumor stasis is reached.

References

[1] Phan, Chiuyen et al. “Isomorphous Crystals Formed by the Similar Supramolecular Motifs in Sorafenib Hydrochloride and Regorafenib Hydrochloride Salts.” 2019. 0.

Regorafenib (Hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Regorafenib (Hydrochloride) Suppliers

China 113 India 1 United States 8 Global 122

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9459
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

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View Lastest Price from Regorafenib (Hydrochloride) manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Regorafenib (Hydrochloride) 835621-07-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-09

Henan Bao Enluo International TradeCo.，LTD

Product: Regorafenib (Hydrochloride) 835621-07-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-07-25

Handan Tongyi New Material Technology Co., Ltd

Product: Regorafenib (Hydrochloride) 835621-07-3
Price: US $100.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99.9%
Supply Ability: 800kgs%month
Release date: 2021-03-08

835621-07-3, Regorafenib (Hydrochloride)Related Search:

4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide (S,S')-3-METHYL-1-(2-PIPERIDINOPHENYL)BUTYLAMINE, N-ACETYL-GLUTAMATE SALT 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate Regorafenib Bortezomib Abiraterone

BAY73-4506 hydrochloride

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrochloride

Regafenib HCL

Regafenib hydrochloride

2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, monohydrochloride

4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrochloride (1:1)

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydr

Regorafenib (Hydrochloride)

Regorafenib HCl

4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride

Regorafenib HC

Powder Regorafenib Hydrochloride CAS

Regorafenib Hydrochloride/BAY73-4506 hydrochloride

Regorafenib HCl (BAY-73-4506)

egorafenib (Hydrochloride)

5-Diiodotyrosine Dihydrate

Regofini

2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrochloride (1:1)

4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-Pyridinecarboxamide hydrochloride (1:1)

4-4-4-Chloro-3-(trifluoromethyl)phenylaminocarbonylamino-3-fluorophenoxy-N-methylpyridin-2-carboxamide HCl

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydrochloride

835621-07-3

C21H15ClF4N4O3ClH

C21H15ClF4N4O3HCl

C21H16Cl2F4N4O3