A-385358
- Product Name
- A-385358
- CAS No.
- 406228-55-5
- Chemical Name
- A-385358
- Synonyms
- A-385358;Paclitaxel Impurity 60;A-385358, 10 mM in DMSO;Bcl-2 Family,A 385358,Inhibitor,A-385358,A385358,inhibit;(S)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide;(R)-N-((4-((4-(Dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide;Benzamide, N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-4-(4,4-dimethyl-1-piperidinyl)-
- CBNumber
- CB52624922
- Molecular Formula
- C32H41N5O5S2
- Formula Weight
- 639.83
- MOL File
- 406228-55-5.mol
A-385358 Property
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (195.36 mM)
- form
- Solid
- pka
- 3.71±0.10(Predicted)
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- A101035
- Product name
- A-385358
- Packaging
- 1mg
- Price
- $285
- Updated
- 2021/12/16
A-385358 Chemical Properties,Usage,Production
Uses
A-385358, is a selective inhibitor of Bcl-XL with Kis, in vitro. In vivo, A-385358, in combination with the lower dose of paclitaxel produces a significant reduction in tumor growth (%T/C) compare with paclitaxel monotherapy.
in vivo
The combination of A-385358 given at 100 mg/kg/d plus the lower dose of paclitaxel produces a significant reduction in tumor growth (%T/C) compare with paclitaxel monotherapy. This combination also yields a >100% increase in time for tumors to reach 900 mm3 (%ILS) compare with vehicle control. Maximal efficacy is observed during the dosing period for A-385358, with slow but steady increase in the tumor growth after termination of treatment. The combination of A-385358 at 75 mg/kg/d plus paclitaxel at 30 mg/kg/d is also well tolerated and inhibits tumor growth rate by nearly 80%. Significant effects on tumor growth relative to paclitaxel monotherapy are observed with doses as low as 50 mg/kg/d[1].
IC 50
Bcl-xL: 0.8 nM (Ki); Bcl-2: 67 nM (Ki)
A-385358 Preparation Products And Raw materials
Raw materials
Preparation Products
A-385358 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
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- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
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