AM-095
- Product Name
- AM-095
- CAS No.
- 1345614-59-6
- Chemical Name
- AM-095
- Synonyms
- AM-095;AM095 sodium;AM095 >=98% (HPLC);AM-095;AM095;AM 095;AM095 hydrochloride;AM095 (Sodium Salt);LPL Receptor,AM095,inhibit,Lysophospholipid Receptor,Inhibitor,AM-095,AM 095;sodium,2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetate;(2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid) sodium salt;4'-[3-Methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid sodium salt (1:1)
- CBNumber
- CB52627312
- Molecular Formula
- C27H25N2NaO5
- Formula Weight
- 480.5
- MOL File
- 1345614-59-6.mol
AM-095 Property
- storage temp.
- room temp
- solubility
- ≥23.9 mg/mL in DMSO; insoluble in H2O; ≥16.77 mg/mL in EtOH with ultrasonic
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- A3166
- Product name
- AM095
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- A3166
- Product name
- AM095
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $115
- Updated
- 2021/12/16
- Product number
- CS-1118
- Product name
- AM095
- Purity
- 99.72%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- A3166
- Product name
- AM095
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-1118
- Product name
- AM095
- Purity
- 99.72%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2021/12/16
AM-095 Chemical Properties,Usage,Production
Biological Activity
am095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (lpa1) with ic50 values of 0.73 and 0.98 μm for mouse or recombinant human lpa1, respectively [1].
in vitro
am095 has shown to inhibit lpa1-induced chemotaxis of both mouse lpa1/cho cells and human a2058 melanoma cells with ic50 values of 0.78 μm and 0.23μm [1].
in vivo
am095 could dose-dependently block lpa-induced histamine release with an ed50 value of 8.3 mg/kg in mice. additionally, am095 has been revealed to remarkably reduce the balf collagen and protein with an ed50 value of 10 mg/kg in lungs. am095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice [1].
target
LPA1 receptor
References
[1] swaney js1, chapman c, correa ld, stebbins kj, broadhead ar, bain g, santini am, darlington j, king cd, baccei cs, lee c, parr ta, roppe jr, seiders tj, ziff j, prasit p, hutchinson jh, evans jf, lorrain ds. pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. j pharmacol exp ther. 2011 mar;336(3):693-700.
AM-095 Preparation Products And Raw materials
Raw materials
Preparation Products
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