ChemicalBook > CAS DataBase List > Oxamic acid sodium salt

Oxamic acid sodium salt

Product Name
Oxamic acid sodium salt
CAS No.
565-73-1
Chemical Name
Oxamic acid sodium salt
Synonyms
SODIUM OXAMATE;oxamate sodium;Grass sodiuM acid;oxamic acid sodium;Oxamate Sodium Salt;OXAMIC ACID SODIUM SALT;sodium carbamoylformate;sodiuM 2-aMino-2-oxoacetate;Oxamic acid, sodium salt,98%;AMINOOXOACETIC ACID SODIUM SALT
CBNumber
CB5262762
Molecular Formula
C2H2NNaO3
Formula Weight
111.03
MOL File
565-73-1.mol
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Oxamic acid sodium salt Property

Melting point:
300 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
PBS (pH 7.2): 10 mg/ml
form 
solid
Water Solubility 
Soluble in water (10 mg/ml).
BRN 
6538153
InChI
InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1
InChIKey
RQVZIJIQDCGIKI-UHFFFAOYSA-M
SMILES
C(=O)(N)C([O-])=O.[Na+]
CAS DataBase Reference
565-73-1(CAS DataBase Reference)
EPA Substance Registry System
Sodium oxamate (565-73-1)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
TSCA 
Yes
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O2751
Product name
Sodium oxamate
Purity
≥98%
Packaging
5G
Price
$136
Updated
2024/03/01
Sigma-Aldrich
Product number
O2751
Product name
Sodium oxamate
Purity
≥98%
Packaging
25G
Price
$569
Updated
2024/03/01
Sigma-Aldrich
Product number
O2751
Product name
Sodium oxamate
Purity
≥98%
Packaging
100G
Price
$987
Updated
2024/03/01
Alfa Aesar
Product number
A16532
Product name
Oxamic acid sodium salt, 98%
Packaging
5g
Price
$42.6
Updated
2024/03/01
Alfa Aesar
Product number
A16532
Product name
Oxamic acid sodium salt, 98%
Packaging
25g
Price
$112
Updated
2024/03/01
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Oxamic acid sodium salt Chemical Properties,Usage,Production

Description

Oxamic acid sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis. Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells.

Chemical Properties

white crystalline powder

Uses

Oxamic acid sodium salt is a lactate dehydrogenase (LDH) inhibitor. It is a suitable compound to investigate cancer cells that utilize the glycolytic pathway.This compound is suitable for lactate dehydrogenase (LDH) related research. It can be used as an inhibitor of gluconeogenesis useful for anticancer research.

Application

Sodium oxamate, an inhibitor of LDH-C4, prevented the AR induced by lysophosphatidylcholine (LPC) or NADH. Oxamic acid sodium salt is an lactic acid dehydrogenase. Sperm suspension and cytosol fraction activities were inhibited by sodium oxamate. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.

Biochem/physiol Actions

Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes.

in vitro

Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells. Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells. Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells. Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells. Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells.

Oxamic acid sodium salt Preparation Products And Raw materials

Raw materials

Ethyl oxalyl monochloride Ethanol Toluene Diethyl oxalate Tetrahydrofuran Ethyl acetate Sodium hydroxide ETHYL OXAMATE Ammonia

Preparation Products

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View Lastest Price from Oxamic acid sodium salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Oxamic acid sodium salt 565-73-1
Price
US $0.00/G
Min. Order
50G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-07
Career Henan Chemical Co
Product
OXAMIC ACID SODIUM SALT 565-73-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-09

565-73-1, Oxamic acid sodium saltRelated Search:

Sodium phytate ETHYL OXAMATE Ferric ammonium oxalate trihydrate Stannous oxalate POTASSIUM TITANIUM OXALATE DIHYDRATE Ferrous oxalate dihydrate Potassium binoxalate EC 2.7.1.40 Oxalic acid Oxamic acid SODIUM GLYOXYLATE Oxamic acid sodium salt

  • aminooxo-aceticacimonosodiumsalt
  • AMINOOXOACETIC ACID SODIUM SALT
  • OXALIC ACID MONOAMIDE SODIUM SALT
  • OXAMIC ACID SODIUM SALT
  • SODIUM OXAMATE
  • oxamic acid sodium
  • OxamicacidsodiumsaltOxamicacidsodiumsalt
  • Aminooxoacetic acid sodium salt, Oxalic acid monoamide sodium salt, Oxamic acid sodium salt
  • 2-Amino-2-oxoacetic acid sodium salt
  • Oxamic acid, sodium salt,98%
  • Sodium oxamate,Aminooxoacetic acid sodium salt, Oxalic acid monoamide sodium salt, Oxamic acid sodium salt
  • Grass sodiuM acid
  • sodiuM 2-aMino-2-oxoacetate
  • Oxamate Sodium Salt
  • Acetic acid,2-amino-2-oxo-, sodium salt (1:1)
  • OXAMIC ACID SODIUM SALT USP/EP/BP
  • oxamate sodium
  • sodium carbamoylformate
  • 565-73-1
  • H2NCOCO2Na
  • NH2COCOONa
  • C2H2NNaO3
  • C2H2NO3Na
  • L to O
  • Lactic dehydrogenase, L-
  • Biochemicals and Reagents
  • BioChemical
  • Chelators
  • Enzyme Inhibitors by Type
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme