GDC-0068

Product Name: GDC-0068
CAS No.: 1001264-89-6
Chemical Name: GDC-0068
Synonyms: Ipatasertib;Cenicriviroc mesylate;RG7440;CS-543;GDC-0068;EOS-62198;patasertib;GDC-0068(RG7440);GDC-0068 USP/EP/BP;Ipatasertib (GDC-0068)
CBNumber: CB52627897
Molecular Formula: C24H32ClN5O2
Formula Weight: 458
MOL File: 1001264-89-6.mol

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GDC-0068 Property

Melting point:: >106°C (dec.)
Boiling point:: 669.4±55.0 °C(Predicted)
Density: 1.254
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: Soluble in DMSO.
pka: 13.11±0.40(Predicted)
form: Solid
color: peachy

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67082
Product name: GDC-0068, 98%
Packaging: 5mg
Price: $241
Updated: 2023/06/20

Cayman Chemical

Product number: 18412
Product name: GDC-0068
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 18412
Product name: GDC-0068
Purity: ≥98%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 18412
Product name: GDC-0068
Purity: ≥98%
Packaging: 10mg
Price: $437
Updated: 2024/03/01

Cayman Chemical

Product number: 18412
Product name: GDC-0068
Purity: ≥98%
Packaging: 25mg
Price: $957
Updated: 2024/03/01

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GDC-0068 Chemical Properties,Usage,Production

Uses

DC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively.

Uses

(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.

Uses

GDC-0068 is a highly selective AKT inhibitor targeting Akt1 , Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.

Definition

ChEBI: (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl]-3-(propan-2-ylamino)-1-propanone is a N-arylpiperazine.

Biological Activity

gdc-0068 (rg7440) is a highly selective small molecule inhibitor of akt with ic50s of 5, 18 and 8 nm for akt1, akt2 and akt3. the pi3k-akt pathway regulates cell growth, survival and tumorigenesis. gdc-0068 binds to and blocks the activation of akt, which result in cell cycle arrest, inhibition of tumor cell proliferation and induction of tumor cell death. pi3k-akt is pathway frequently activated in tumors, thus tumors with pten or pi3k mutations, which lead to activation of akt are with high sensitivity to gdc-0068. gdc-0068 is now used for the treatment of human cancers.1. discovery and preclinical pharmacology of a selective atp-competitive akt inhibitor (gdc-0068) for the treatment of human tumors. jf blake, r xu, jr bencsik, d xiao… - journal of medicinal 20122. lin j, sampath d, nannini ma, et al: targeting activated akt with gdc-0068, a novel selective akt inhibitor that is efficacious in multiple tumor models. clin canc res 2013, 19:1760–1772.

target

Akt1

GDC-0068 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0068 Suppliers

Canada 1 China 136 India 3 United States 19 Global 159

AdooQ BioScience, LLC

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BOC Sciences

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View Lastest Price from GDC-0068 manufacturers

Career Henan Chemical Co

Product: GDC-0068 1001264-89-6
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1001264-89-6, GDC-0068Related Search:

Cenicriviroc 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol MK-2206 2HCl Alpelisib (BYL719) Pictilisib AZD5363 Rapamycin

GDC-0068

GDC-0068(RG7440)

RG7440

(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

Ipatasertib (GDC-0068)

GDC0068;GDC 0068;GDC-0068;RG7440;RG-7440;;RG 7440

Ipatasertib

(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one

(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone Ipatasertib (GDC-0068)

GDC-0068 (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

(2S)-2-(4-Chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl}-3-(isopropylamino)-1-propanone

Ipatasertib (GDC-0068,RG 7440)

Cenicriviroc mesylate

GDC-0068;RG7440; GDC0068; GDC 0068; RG-7440; RG 7440

GDC-0068 (Ipatasertib)

(S)-2-(4-Chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-

EOS-62198

GDC-0068, 98%, a highly selective pan-Akt inhibitor

CS-543

GDC0068;GDC 0068;GDC-0068

GDC-0068 (Ipatasertib,RG-7440)

1-Propanone, 2-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-, (2S)-

GDC-0068 USP/EP/BP

patasertib

GDC-0068 Ipatasertib RG-7440 GDC0068 RG7440

1001264-89-6

1002364-89-6

C24H32ClN5O2

Akt

mTOR

PI3K

Inhibitors

Inhibitor

PI3K/Akt/mTOR