Skepinone-L

Product Name: Skepinone-L
CAS No.: 1221485-83-1
Chemical Name: Skepinone-L
Synonyms: CS-1010;CBS3830;SKEPINONE;Skepinone-L;Skepinone-L, >=98%;Skepinone-L (CBS3830);Skepinone-L USP/EP/BP;inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
CBNumber: CB52628399
Molecular Formula: C24H21F2NO4
Formula Weight: 425.42
MOL File: 1221485-83-1.mol

More

Less

Skepinone-L Property

Melting point:: 130-134°C
Boiling point:: 629.0±55.0 °C(Predicted)
Density: 1.384±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 13.49±0.20(Predicted)
form: Solid
color: Light Yellow to Yellow

More

Less

Safety

HS Code: 2922500090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 16974
Product name: Skepinone-L
Purity: ≥98%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 16974
Product name: Skepinone-L
Purity: ≥98%
Packaging: 1mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 16974
Product name: Skepinone-L
Purity: ≥98%
Packaging: 5mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 16974
Product name: Skepinone-L
Purity: ≥98%
Packaging: 10mg
Price: $665
Updated: 2024/03/01

TRC

Product number: S499000
Product name: Skepinone-L
Packaging: 25mg
Price: $945
Updated: 2021/12/16

More

Less

Skepinone-L Chemical Properties,Usage,Production

Description

Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC₅₀s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC₅₀ = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A₂ in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.

Uses

Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.

target

p38-MAPK

References

[1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143.

Skepinone-L Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Skepinone-L Suppliers

China 64 India 1 United States 14 Global 79

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

International Laboratory Limited

Tel: --
Fax: --
Email: admin@intlab.org
Country: United States
ProdList: 5356
Advantage: 50

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

1221485-83-1, Skepinone-LRelated Search:

Sivelestat sodium Sitaxentan sodium Sitravatinib MK-2206 2HCl 1,9-Pyrazoloanthrone Saracatinib TAK-632 PP2 Fedratinib

5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-

Skepinone-L, >=98%

3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one

(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann

Skepinone-L

2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one

CS-1010

SKEPINONE

CBS3830

Skepinone-L USP/EP/BP

Skepinone-L (CBS3830)

(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one

inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor

1221485-83-1

C24H21F2NO4

MAPK

Inhibitors