Boc-NH-PEG4-CH2COOH
- Product Name
- Boc-NH-PEG4-CH2COOH
- CAS No.
- 876345-13-0
- Chemical Name
- Boc-NH-PEG4-CH2COOH
- Synonyms
- NHBoc-PEG4-CH2COOH;Boc-NH-PEG(3)-COOH;Boc-NH-PEG4-CH2CO0H;Boc-NH-(PEG)4-CH2COOH;t-Boc-N-amido-PEG4-CH2CO2H;Boc-NH-PEG(3)-COOH(16atoMs);t-boc-N-amido-PEG4-acetic acid;14-(Boc-amino)-3,6,9,12-tetraoxatetradecan-1-oic Acid;2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid;14-{[(tert-butoxy)carbonyl]amino}-3,6,9,12-tetraoxatetradecanoic acid
- CBNumber
- CB52648724
- Molecular Formula
- C15H29NO8
- Formula Weight
- 351.39
- MOL File
- 876345-13-0.mol
Boc-NH-PEG4-CH2COOH Property
- Boiling point:
- 493.6±40.0 °C(Predicted)
- Density
- 1.138±0.06 g/cm3(Predicted)
- refractive index
- n/D 1.4641
- storage temp.
- -20°C
- pka
- 3.39±0.10(Predicted)
- form
- Viscous Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C15H29NO8/c1-15(2,3)24-14(19)16-4-5-20-6-7-21-8-9-22-10-11-23-12-13(17)18/h4-12H2,1-3H3,(H,16,19)(H,17,18)
- InChIKey
- SHMYENBXRNPSOG-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCCOCCOCCOCCOCC(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 902551
- Product name
- BocNH-PEG4-acid
- Packaging
- 250MG
- Price
- $264.04
- Updated
- 2025/07/31
- Product number
- 902551
- Product name
- BocNH-PEG4-acid
- Packaging
- 1G
- Price
- $801
- Updated
- 2025/07/31
- Product number
- AS104026
- Product name
- BocNH-PEG4-CH2COOH
- Purity
- 95+%
- Packaging
- 1g
- Price
- $532
- Updated
- 2021/12/16
- Product number
- CS-0025223
- Product name
- Boc-NH-PEG4-CH2COOH
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- BP-23531
- Product name
- t-Boc-N-amido-PEG4-CH2CO2H
- Purity
- 98%
- Packaging
- 500mg
- Price
- $280
- Updated
- 2021/12/16
Boc-NH-PEG4-CH2COOH Chemical Properties,Usage,Production
Description
t-Boc-N-amido-PEG4-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation
reaction suitability
reaction type: Pegylations
reagent type: cross-linking reagent
IC 50
Cleavable Linker; Alkyl/ether; PEGs
Boc-NH-PEG4-CH2COOH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Boc-NH-PEG4-CH2COOH manufacturers
- Product
- BocNH-PEG4-CH2COOH 876345-13-0
- Price
- US $133.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2025-11-20
- Product
- 2,2-dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid 876345-13-0
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-12
- Product
- Boc-NH-PEG4-CH2COOH 876345-13-0
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-06