Boc-NH-PEG(3)-COOH

ChemicalBook > CAS DataBase List > Boc-NH-PEG(3)-COOH

Product Name: Boc-NH-PEG(3)-COOH
CAS No.: 876345-13-0
Chemical Name: Boc-NH-PEG(3)-COOH
Synonyms: NHBoc-PEG4-CH2COOH;Boc-NH-PEG(3)-COOH;Boc-NH-PEG4-CH2CO0H;Boc-NH-(PEG)4-CH2COOH;t-Boc-N-amido-PEG4-CH2CO2H;Boc-NH-PEG(3)-COOH(16atoMs);t-boc-N-amido-PEG4-acetic acid;14-(Boc-amino)-3,6,9,12-tetraoxatetradecan-1-oic Acid;2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid;5,8,11,14-Tetraoxa-2-azahexadecanedioic acid, 1-(1,1-dimethylethyl) ester
CBNumber: CB52648724
Molecular Formula: C15H29NO8
Formula Weight: 351.39
MOL File: 876345-13-0.mol

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Boc-NH-PEG(3)-COOH Property

Boiling point:: 493.6±40.0 °C(Predicted)
Density: 1.138±0.06 g/cm3(Predicted)
storage temp.: -20°C
pka: 3.39±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 902551
Product name: BocNH-PEG4-acid
Packaging: 250MG
Price: $267
Updated: 2023/06/20

Sigma-Aldrich

Product number: 902551
Product name: BocNH-PEG4-acid
Packaging: 1G
Price: $747
Updated: 2023/06/20

Activate Scientific

Product number: AS104026
Product name: BocNH-PEG4-CH2COOH
Purity: 95+%
Packaging: 1g
Price: $532
Updated: 2021/12/16

ChemScene

Product number: CS-0025223
Product name: Boc-NH-PEG4-CH2COOH
Purity: ≥97.0%
Packaging: 250mg
Price: $160
Updated: 2021/12/16

BroadPharm

Product number: BP-23531
Product name: t-Boc-N-amido-PEG4-CH2CO2H
Purity: 98%
Packaging: 500mg
Price: $280
Updated: 2021/12/16

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Boc-NH-PEG(3)-COOH Chemical Properties,Usage,Production

Description

t-Boc-N-amido-PEG4-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation

Boc-NH-PEG(3)-COOH Preparation Products And Raw materials

Raw materials

Preparation Products

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876345-13-0, Boc-NH-PEG(3)-COOHRelated Search:

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Boc-NH-PEG4-CH2CO0H

876345-13-0

C15H29NO8