ChemicalBook > CAS DataBase List > N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide
N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide
- Product Name
- N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide
- CAS No.
- 1355326-35-0
- Chemical Name
- N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide
- Synonyms
- CS-720;AGI5198;IDH-C35;IDH C35;AGI 5196;IDH-C35 /IDHC35;AGI-5198, >=98%;AGI-5198 (IDH-C35);IDH-C35;AGI5198;AGI 5196;AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35.
- CBNumber
- CB52652200
- Molecular Formula
- C27H31FN4O2
- Formula Weight
- 462.56
- MOL File
- 1355326-35-0.mol
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N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide Property
- Boiling point:
- 707.6±60.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble3mg/mL, clear
- form
- powder
- pka
- 14.02±0.20(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- FNYGWXSATBUBER-UHFFFAOYSA-N
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0839
- Product name
- IDH-C35
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $138
- Updated
- 2023/01/07
Sigma-Aldrich
- Product number
- SML0839
- Product name
- IDH-C35
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $530
- Updated
- 2023/01/07
Cayman Chemical
- Product number
- 14624
- Product name
- AGI-5198
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $93
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14624
- Product name
- AGI-5198
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $252
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14624
- Product name
- AGI-5198
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $412
- Updated
- 2024/03/01
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N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide Chemical Properties,Usage,Production
Description
AGI-5198 (135526-35-0) is a potent (IC50?= 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1? It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2? This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) from alpha-ketoglutarate (2-OG).
Uses
AGI5198 inhibits mutant IDH1 (isocitrate dehydrogenase 1) in cancer cells which delays growth and promotes differentiation of the glioma cells.
Uses
AGI-5198 has been used as a negative control in ligand dilution series.
Biochem/physiol Actions
In human chondrosarcoma cell line JJ012, AGI-5198 promotes apoptosis and G2/M cell cycle arrest. It also prevents the generation of colony in chondrosarcoma cell lines. AGI-5198 hinders the multiplication of cell and induces demethylation of H3K9me3 and H3K27me3.
target
R132H-IDH1
storage
Store at -20°C
References
1) Popovici-Muller?et al. (2012),?Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG In Vivo; ACS Med. Chem. Lett.,?3?850 2) Rohle?et al. (2013),?An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells; Science,?340?626
N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- AGI5198 1355326-35-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99% HPLC
- Supply Ability
- 2000tons
- Release date
- 2019-12-30