AGI6780
Description In vitro- Product Name
- AGI6780
- CAS No.
- 1432660-47-3
- Chemical Name
- AGI6780
- Synonyms
- CS-1905;CS-1019;AGI6780;AGI-6780, >=98%;AGI6780 USP/EP/BP;AGI-6780, that potently and selectively inhibits the tumor-associated mutant IDH2R140Q;N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoroMethyl)phenyl)ureido)benzenesulfonaMide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide AGI-6780
- CBNumber
- CB42652324
- Molecular Formula
- C21H18F3N3O3S2
- Formula Weight
- 481.51
- MOL File
- 1432660-47-3.mol
AGI6780 Property
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥22.25 mg/mL in DMSO; insoluble in H2O; ≥100.8 mg/mL in EtOH
- form
- solid
- pka
- 11.78±0.20(Predicted)
Safety
- HS Code
- 2935909099
N-Bromosuccinimide Price
- Product number
- SML0895
- Product name
- AGI-6780
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $150
- Updated
- 2024/03/01
- Product number
- SML0895
- Product name
- AGI-6780
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $598
- Updated
- 2024/03/01
- Product number
- 5.09880
- Product name
- IDH2 Inhibitor, R140Q Somatic Mutant-Specific, AGI-6780 - CAS 1432660-47-3 - Calbiochem
- Packaging
- 10mg
- Price
- $265
- Updated
- 2024/03/01
- Product number
- 14639
- Product name
- AGI-6780
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 14639
- Product name
- AGI-6780
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $112
- Updated
- 2024/03/01
AGI6780 Chemical Properties,Usage,Production
Description
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.
In vitro
AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples.
Uses
AGI-6780 is a small molecule inhibitor of the tumor associated mutant IDH2 (Isocitrate Dehydrogenase-2) in leukemia cells. This compound is suitable for IDH (isocitrate dehydrogenase) related research.
Biological Activity
agi-6780 is a potent and selective inhibitor of tumor-associated idh2/r140q mutation with ic50 value of 23 nm [1].agi-6780 could significantly reduce intracellular concentration of 2hg in the human glioblastoma tf1/r140q cells, as well as reverse idh2/r140q-mediated differentiation block in tf1 cells in the presence of epo. agi-6780 could restore klf1 and hemoglobin g1/2 expressions in the epo-induced tf1/r140q cells [1].
target
IDH2-R140Q
References
[1] wang f1, travins j, delabarre b, penard-lacronique v, schalm s, hansen e, straley k, kernytsky a, liu w, gliser c, yang h, gross s, artin e, saada v,mylonas e, quivoron c, popovici-muller j, saunders jo, salituro fg, yan s, murray s, wei w, gao y, dang l, dorsch m, agresta s, schenkein dp, biller sa, su sm, de botton s, yen ke. targeted inhibition of mutant idh2 in leukemia cells induces cellular differentiation. science. 2013 may 3;340(6132):622-6.
AGI6780 Preparation Products And Raw materials
Raw materials
Preparation Products
AGI6780 Suppliers
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View Lastest Price from AGI6780 manufacturers
- Product
- AGI6780 1432660-47-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 5g
- Purity
- 99% HPLC
- Supply Ability
- 2000tons
- Release date
- 2019-12-30
- Product
- AGI6780 1432660-47-3
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20