GDC-0077

Product Name: GDC-0077
CAS No.: 2060571-02-8
Chemical Name: GDC-0077
Synonyms: RG 6114;CPD1573;GDC-0077;RO 7113755;Inavolisib;GDC-0077 (RG6114);GDC-0077 Inavolisib;Inavolisib (GDC-0077);Inavolisib, 10 mM in DMSO;GDC-0077; RG 6114; RO 7113755
CBNumber: CB43175543
Molecular Formula: C18H19F2N5O4
Formula Weight: 407.37
MOL File: 2060571-02-8.mol

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GDC-0077 Property

Boiling point:: 698.0±65.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:110.0(Max Conc. mg/mL);245.47(Max Conc. mM)
pka: 15.89±0.50(Predicted)
form: Solid
color: Off-white to yellow
InChIKey: SGEUNORSOZVTOL-CABZTGNLSA-N
SMILES: C(N)(=O)[C@@H](NC1C=C2OCCN3C=C(N4[C@H](C(F)F)COC4=O)N=C3C2=CC=1)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PRK0000448
Product name: (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $451.72
Updated: 2021/12/16

ChemScene

Product number: CS-6459
Product name: GDC-0077
Purity: 98.94%
Packaging: 5mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-6459
Product name: GDC-0077
Purity: 98.94%
Packaging: 10mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-6459
Product name: GDC-0077
Purity: 98.94%
Packaging: 25mg
Price: $1260
Updated: 2021/12/16

ChemScene

Product number: CS-6459
Product name: GDC-0077
Purity: 98.94%
Packaging: 50mg
Price: $2020
Updated: 2021/12/16

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GDC-0077 Chemical Properties,Usage,Production

Description

Inavolisib, or GDC-0077, is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and inhibits the growth and survival of PI3K-overexpressing tumor cells. The IUPAC name of this compound is (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide.

Uses

Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor (IC50=0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib can be used for the study of breast cancer[1].

in vitro

GDC-0077 (RG6114) is >300-fold more selective for PI3Kα over the other class I PI3K isoforms (β, δ, and γ) and >2000-fold more selective over PIK family members. GDC-0077 selectively degrades mutant PI3Kα in a proteasome-dependent fashion, resulting in a reduction of PI3K pathway activity biomarkers such as pAKT and pPRAS40, inhibition of cell proliferation, and increased apoptosis in human PIK3CA-mutant breast cancer cell lines to a greater extent when compared to PIK3CA wild-type cells.

in vivo

Inavolisib (p.o.) results in tumor regressions, induction of apoptosis, and a reduction of pAKT, pPRAS40, and pS6RP in a dose-dependent fashion in PIK3CA-mutant breast cancer xenograft models^[1].

IC 50

PI3Kα: 0.038 nM (IC₅₀)

References

[1] R Hong, Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies. 2017 San Antonio Breast Cancer Symposium.

GDC-0077 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0077 Suppliers

China 106 United States 3 USA 1 Global 110

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2742
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Shandong Dongde New Materials Co., Ltd

Tel: 13290191024
Email: 3887351301@qq.com
Country: China
ProdList: 1910
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yimo organism

Tel: 15915870272; 15915870272
Email: yimo_bio@163.com
Country: China
ProdList: 446
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Jurong Coupling Biotechnology Co., Ltd.

Tel: 19231718652
Email: 278191416@qq.com
Country: China
ProdList: 482
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 086-15871494362 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 6614
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

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View Lastest Price from GDC-0077 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: Inavolisib (Synonyms: GDC-0077; RG6114) 2060571-02-8
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 98%+ HPLC HNMR
Supply Ability: 20g
Release date: 2024-03-29

2060571-02-8, GDC-0077Related Search:

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- GDC-0623 GDC0575 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one XL518 DONEPEZIL HYDROCHLORIDE TDZD-8 4SC-202 CEP-32496 N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine PURVALANOL A Testolactone AGI6780 CC0651 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine IDO-IN-7

GDC-0077

CPD1573

RG 6114

RO 7113755

GDC-0077; RG 6114; RO 7113755

(2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide

Propanamide, 2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]-, (2S)-

Inavolisib

Inavolisib (GDC-0077)

GDC-0077 Inavolisib

Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit

(S)-2-[[2-[(S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]amino]propanamide

Inavolisib (Synonyms: GDC-0077

(S)-2-((2-((S)-4-(Difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide

Inavolisib (RG-6114, RO-7113755)

(S)-2-((2-((S)-4-(Difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide , Inavolisib

Inavolisib, 10 mM in DMSO

(2S)-2-({4-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,?]tetradeca-1(14),2,4,10,12-pentaen-12-yl}amino)propanamide

Inavolisib (GDC-0077, RG6114)

GDC-0077 (RG6114)

(2S)-2-({4-[(4S)-4-(difluoromethyl)-2-oxo-1, 3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,]tetradeca-1(14),2,4,10,12-pentaen-12-yl}am

2060571-02-8

GDC-0077