ChemicalBook > CAS DataBase List > GDC-0077

GDC-0077

Product Name
GDC-0077
CAS No.
2060571-02-8
Chemical Name
GDC-0077
Synonyms
RG 6114;CPD1573;GDC-0077;RO 7113755;Inavolisib;GDC-0077 Inavolisib;Inavolisib (GDC-0077);GDC-0077; RG 6114; RO 7113755;Inavolisib (Synonyms: GDC-0077;Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit
CBNumber
CB43175543
Molecular Formula
C18H19F2N5O4
Formula Weight
407.37
MOL File
2060571-02-8.mol
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GDC-0077 Property

Boiling point:
698.0±65.0 °C(Predicted)
Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:110.0(Max Conc. mg/mL);245.47(Max Conc. mM)
pka
15.89±0.50(Predicted)
form 
Solid
color 
Off-white to yellow
InChIKey
SGEUNORSOZVTOL-CABZTGNLSA-N
SMILES
C(N)(=O)[C@@H](NC1C=C2OCCN3C=C(N4[C@H](C(F)F)COC4=O)N=C3C2=CC=1)C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
PRK0000448
Product name
(S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMIDE
Purity
95.00%
Packaging
5MG
Price
$451.72
Updated
2021/12/16
ChemScene
Product number
CS-6459
Product name
GDC-0077
Purity
98.94%
Packaging
5mg
Price
$540
Updated
2021/12/16
ChemScene
Product number
CS-6459
Product name
GDC-0077
Purity
98.94%
Packaging
10mg
Price
$900
Updated
2021/12/16
ChemScene
Product number
CS-6459
Product name
GDC-0077
Purity
98.94%
Packaging
25mg
Price
$1260
Updated
2021/12/16
ChemScene
Product number
CS-6459
Product name
GDC-0077
Purity
98.94%
Packaging
50mg
Price
$2020
Updated
2021/12/16
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GDC-0077 Chemical Properties,Usage,Production

Description

Inavolisib, or GDC-0077, is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and inhibits the growth and survival of PI3K-overexpressing tumor cells. The IUPAC name of this compound is (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide.

in vitro

GDC-0077 (RG6114) is >300-fold more selective for PI3Kα over the other class I PI3K isoforms (β, δ, and γ) and >2000-fold more selective over PIK family members. GDC-0077 selectively degrades mutant PI3Kα in a proteasome-dependent fashion, resulting in a reduction of PI3K pathway activity biomarkers such as pAKT and pPRAS40, inhibition of cell proliferation, and increased apoptosis in human PIK3CA-mutant breast cancer cell lines to a greater extent when compared to PIK3CA wild-type cells.

GDC-0077 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0077 Suppliers

China 69 United States 3 USA 1 Global 73
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View Lastest Price from GDC-0077 manufacturers

Hubei Chuchang Biotech Co., Ltd.
Product
Inavolisib (Synonyms: GDC-0077; RG6114) 2060571-02-8
Price
US $0.00-0.00/mg
Min. Order
5mg
Purity
98%+ HPLC HNMR
Supply Ability
20g
Release date
2024-03-29

2060571-02-8, GDC-0077Related Search:

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- GDC-0623 GDC0575 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one XL518 DONEPEZIL HYDROCHLORIDE TDZD-8 4SC-202 CEP-32496 N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine PURVALANOL A Testolactone AGI6780 CC0651 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine IDO-IN-7

  • GDC-0077
  • CPD1573
  • RG 6114
  • RO 7113755
  • GDC-0077; RG 6114; RO 7113755
  • (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
  • Propanamide, 2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]-, (2S)-
  • Inavolisib
  • Inavolisib (GDC-0077)
  • GDC-0077 Inavolisib
  • Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit
  • (S)-2-[[2-[(S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]amino]propanamide
  • Inavolisib (Synonyms: GDC-0077
  • (S)-2-((2-((S)-4-(Difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide
  • 2060571-02-8
  • GDC-0077