GDC-0077

ChemicalBook > CAS DataBase List > GDC-0077

Product Name: GDC-0077
CAS No.: 2060571-02-8
Chemical Name: GDC-0077
Synonyms: RG 6114;CPD1573;GDC-0077;RO 7113755;Inavolisib;GDC-0077 Inavolisib;Inavolisib (GDC-0077);GDC-0077; RG 6114; RO 7113755;Inavolisib (Synonyms: GDC-0077;Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit
CBNumber: CB43175543
Molecular Formula: C18H19F2N5O4
Formula Weight: 407.37
MOL File: 2060571-02-8.mol

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GDC-0077 Property

Boiling point:: 698.0±65.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:110.0(Max Conc. mg/mL);245.47(Max Conc. mM)
pka: 15.89±0.50(Predicted)
form: Solid
color: Off-white to yellow
InChIKey: SGEUNORSOZVTOL-CABZTGNLSA-N
SMILES: C(N)(=O)[C@@H](NC1C=C2OCCN3C=C(N4[C@H](C(F)F)COC4=O)N=C3C2=CC=1)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PRK0000448
Product name: (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $451.72
Updated: 2021/12/16

ChemScene

Product number: CS-6459
Product name: GDC-0077
Purity: 98.94%
Packaging: 5mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-6459
Product name: GDC-0077
Purity: 98.94%
Packaging: 10mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-6459
Product name: GDC-0077
Purity: 98.94%
Packaging: 25mg
Price: $1260
Updated: 2021/12/16

ChemScene

Product number: CS-6459
Product name: GDC-0077
Purity: 98.94%
Packaging: 50mg
Price: $2020
Updated: 2021/12/16

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GDC-0077 Chemical Properties,Usage,Production

Description

Inavolisib, or GDC-0077, is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and inhibits the growth and survival of PI3K-overexpressing tumor cells. The IUPAC name of this compound is (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide.

in vitro

GDC-0077 (RG6114) is >300-fold more selective for PI3Kα over the other class I PI3K isoforms (β, δ, and γ) and >2000-fold more selective over PIK family members. GDC-0077 selectively degrades mutant PI3Kα in a proteasome-dependent fashion, resulting in a reduction of PI3K pathway activity biomarkers such as pAKT and pPRAS40, inhibition of cell proliferation, and increased apoptosis in human PIK3CA-mutant breast cancer cell lines to a greater extent when compared to PIK3CA wild-type cells.

GDC-0077 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0077 Suppliers

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View Lastest Price from GDC-0077 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: Inavolisib (Synonyms: GDC-0077; RG6114) 2060571-02-8
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 98%+ HPLC HNMR
Supply Ability: 20g
Release date: 2024-03-29

2060571-02-8, GDC-0077Related Search:

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GDC-0077

CPD1573

RG 6114

RO 7113755

GDC-0077; RG 6114; RO 7113755

(2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide

Propanamide, 2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]-, (2S)-

Inavolisib

Inavolisib (GDC-0077)

GDC-0077 Inavolisib

Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit

(S)-2-[[2-[(S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]amino]propanamide

Inavolisib (Synonyms: GDC-0077

2060571-02-8