CC0651

Product Name: CC0651
CAS No.: 1319207-44-7
Chemical Name: CC0651
Synonyms: CC0651;CC0651,CC-0651;(2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid;4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid;L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-
CBNumber: CB42627678
Molecular Formula: C20H21Cl2NO6
Formula Weight: 442.29
MOL File: 1319207-44-7.mol

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CC0651 Property

Boiling point:: 755.7±60.0 °C(Predicted)
Density: 1.410±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 56 mg/mL (126.61 mM)
pka: 3.37±0.34(Predicted)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.09704
Product name: Cdc34 Inhibitor, CC0651 - CAS 1319207-44-7 - Calbiochem
Purity: A cell-permeable, selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC?? = 2.5 μM in a Sic1-SCFCdc4 assay).
Packaging: 10MG
Price: $240
Updated: 2023/06/20

TRC

Product number: C263475
Product name: CC0651
Packaging: 2.5mg
Price: $435
Updated: 2021/12/16

TRC

Product number: C263475
Product name: CC0651
Packaging: 1mg
Price: $215
Updated: 2021/12/16

ChemScene

Product number: CS-2109
Product name: CC0651
Purity: 99.52%
Packaging: 5mg
Price: $1176
Updated: 2021/12/16

ChemScene

Product number: CS-2109
Product name: CC0651
Purity: 99.52%
Packaging: 10mg
Price: $1800
Updated: 2021/12/16

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CC0651 Chemical Properties,Usage,Production

General Description

A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC₅₀ = 2.5 μM in a Sic1-SCF^Cdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC₅₀ value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC₅₀ = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27^Kip1 ubiquitination (IC₅₀ = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

CC0651 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC0651 Suppliers

China 28 United Kingdom 1 United States 9 Global 38

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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MedChemexpress LLC

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LETOPHARM LIMITED

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SPIRO PHARMA

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Guangzhou QiYun Biotechnology Co., Ltd.

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Musechem

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shanghai Zeye Biotechnology Co., Ltd.

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Absin Bioscience Inc.

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1319207-44-7, CC0651Related Search:

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(2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid

L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-

CC0651

4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid

CC0651,CC-0651

1319207-44-7

C20H21Cl2NO6