J 147
- Product Name
- J 147
- CAS No.
- 1146963-51-0
- Chemical Name
- J 147
- Synonyms
- J 147;CS-1446;J147-API;J147/J-147;J-147?, >98%;Nootropic J147;J-147, 10 mM in DMSO;J 147(Nootropic Powder);CAS 1146963-51-0 J 147;J147 MOQ is 10g/bag j147
- CBNumber
- CB52652639
- Molecular Formula
- C18H17F3N2O2
- Formula Weight
- 350.33
- MOL File
- 1146963-51-0.mol
J 147 Property
- Boiling point:
- 412.8±55.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO:68.0(Max Conc. mg/mL);194.1(Max Conc. mM)
- form
- Powder
- pka
- 0.80±0.50(Predicted)
- color
- Off-white to pink
- InChI
- InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3
- InChIKey
- HYMZAYGFKNNHDN-UHFFFAOYSA-N
- SMILES
- C(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 5081
- Product name
- J147
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $182
- Updated
- 2021/12/16
- Product number
- 5081
- Product name
- J147
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $745
- Updated
- 2021/12/16
- Product number
- J210300
- Product name
- J147
- Packaging
- 10mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- CS-3688
- Product name
- J-147
- Purity
- 99.87%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B5804
- Product name
- J147
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $100
- Updated
- 2021/12/16
J 147 Chemical Properties,Usage,Production
Uses
J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer''s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer''s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
Definition
ChEBI: J147 is an anilide.
benefits
J 147 improves heart health by lowering blood pressure, boosts metabolism, supports digestive and immune system function, improves cognitive function, has no side effects, and increases physical strength with long-term use. Once there is significant weight loss after taking it, this supplement helps people maintain their weight by reducing cravings and increasing energy levels. Since it helps suppress the hunger hormone that causes overeating, people who use J147 capsules for a long time are more likely to maintain their weight
Biological Activity
J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.
Synthesis
391646-35-8
407-25-0
1146963-51-0
Trifluoroacetic anhydride (0.33 mL, 2.36 mmol) was added slowly and dropwise to a stirred solution of 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide (500 mg, 1.97 mmol) and triethylamine (0.33 mL, 2.36 mmol) in dichloromethane (5 mL) at 0 °C and under nitrogen protection. The reaction mixture was stirred continuously at 0°C for 1.5 hours. Upon completion of the reaction, the mixture was concentrated and the residue was purified by column chromatography using acetone/hexane (1:10) as eluent to afford the target product 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylidene]hydrazide (571 mg, 83% yield) as a light yellow oil.1H NMR (CDCl3) data were as follows: δ7.26-7.23 (m, 4H), 7.19 (d, J = 8.0 Hz, 1H), 7.12 (d, J = 7.5 Hz, 1H), 7.03 (d, J = 8.0 Hz, 1H), 6.92 (dd, J = 8.5,2.0 Hz, 1H), 3.79 (s, 3H), 2.39 (s, 3H), 2.08 (s 3H). High-resolution mass spectrometry (ESI-TOF, m/z) analysis resulted in a calculated value of 351.1320 for C18H18N2O2F3 ([M + H]+); the measured value was 351.1311.
storage
Store at +4°C
References
[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 2, p. 524 - 527
J 147 Preparation Products And Raw materials
Raw materials
Preparation Products
J 147 Suppliers
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View Lastest Price from J 147 manufacturers
- Product
- J 147 1146963-51-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-12-01
- Product
- J 147 1146963-51-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2025-08-26
- Product
- J-147 1146963-51-0
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-21