ChemicalBook > CAS DataBase List > Acethydrazide
Acethydrazide
Description- Product Name
- Acethydrazide
- CAS No.
- 1068-57-1
- Chemical Name
- Acethydrazide
- Synonyms
- ACETOHYDRAZIDE;ACETIC HYDRAZIDE;374;ACETYLHYDRAZINE;Acetyl hydrazide;ACETIC ACID HYDRAZIDE;Acetohydrazid;Acetyl drazide;ENT-61241;NSC 53155
- CBNumber
- CB5266159
- Molecular Formula
- C2H6N2O
- Formula Weight
- 74.08
- MOL File
- 1068-57-1.mol
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Acethydrazide Property
- Melting point:
- 58-68 °C (lit.)
- Boiling point:
- 129 °C/18 mmHg (lit.)
- Density
- 1.0968 (rough estimate)
- refractive index
- 1.4264 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Moist Crystals and Chunks
- pka
- 13.46±0.18(Predicted)
- color
- White
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- BRN
- 506165
- InChIKey
- OFLXLNCGODUUOT-UHFFFAOYSA-N
- CAS DataBase Reference
- 1068-57-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetic acid, hydrazide(1068-57-1)
- EPA Substance Registry System
- Acetic acid hydrazide (1068-57-1)
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Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 22-36/38-68-40-25
- Safety Statements
- 26-36-45-36/37
- RIDADR
- 1759
- WGK Germany
- 1
- RTECS
- AI1225000
- F
- 3-8-10
- TSCA
- Y
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29280090
- Toxicity
- LD50 oral in bird - wild: 42200ug/kg
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- A8309
- Product name
- Acethydrazide
- Purity
- 90%
- Packaging
- 5g
- Price
- $52.1
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- A8309
- Product name
- Acethydrazide
- Purity
- 90%
- Packaging
- 25g
- Price
- $98
- Updated
- 2024/03/01
TCI Chemical
- Product number
- A0789
- Product name
- Acetohydrazide
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $55
- Updated
- 2024/03/01
TCI Chemical
- Product number
- A0789
- Product name
- Acetohydrazide
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $136
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A10969
- Product name
- Acetic hydrazide, 96%
- Packaging
- 25g
- Price
- $53.65
- Updated
- 2024/03/01
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Acethydrazide Chemical Properties,Usage,Production
Description
Acethydrazide is an essential organic intermediate mainly used to synthesize nifuratrone in the pharmaceutical industry. It belongs to the hydrazine/hydrazone group, which plays an important role in the anti-microbial activity. Recently, Acethydrazide has gained significant importance due to its anti-tuberculosis activity. A disease caused by parasites represents a major world health problem with limited therapeutic options. Acethydrazide was synthesized from the reaction between ethyl acetate and hydrazine hydrate in methanol solvent and purified[1-2].
Chemical Properties
White moist crystals and chunks
Uses
Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.
Uses
Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine.
Uses
Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.
Definition
ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.
Purification Methods
Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]
References
[1] S. Nzikayel, A. Ec, Akpan Ij. “Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Acethydrazide Derivative.” Medicinal Chemistry 8 1 (2018): 26–28.
[2] S. Pakdehi, A. S. Moghaddam, M. Sohrabi. “Liquid phase hydrogenation of acethydrazone to N’-methyl acethydrazide over Pd/γ-Al2O3 catalyst.” Brazilian Journal of Chemical Engineering 27 1 (2010): 145–152.
Acethydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acethydrazide manufacturers
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- Product
- Acethydrazide 1068-57-1
- Price
- US $99.00-80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21
hebei hongtan Biotechnology Co., Ltd
- Product
- Acethydrazide 1068-57-1
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-05-16
Jiangsu Suoteng New Material Technology Co, Ltd.
- Product
- Acethydrazide 1068-57-1
- Price
- US $35.00-25.00/KG
- Min. Order
- 1KG
- Purity
- ≥97%
- Supply Ability
- 1000 Tons
- Release date
- 2024-10-24
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