ChemicalBook > CAS DataBase List > Maleic hydrazide

Maleic hydrazide

Product Name
Maleic hydrazide
CAS No.
123-33-1
Chemical Name
Maleic hydrazide
Synonyms
MH;MALAZIDE;1,2-Dihydro-3,6-pyradizinedione;milurit;MAINTAIN;3,6-DIHYDROXYPYRIDAZINE;aleic acid cyclic hydrazide;6-Pyridazinedione,1,2-dihydro-3;1,2-DIHYDRO-3,6-PYRIDAZINEDIONE;3,6-Pyridazinedione, 1,2-dihydro-
CBNumber
CB6247692
Molecular Formula
C4H4N2O2
Formula Weight
112.09
MOL File
123-33-1.mol
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Maleic hydrazide Property

Melting point:
299-301 °C (dec.)(lit.)
Boiling point:
209.98°C (rough estimate)
Density 
1,6 g/cm3
refractive index 
1.4610 (estimate)
Flash point:
300°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
4510mg/l
pka
9.01±0.20(Predicted)
color 
White crystalline
Odor
Odorless
Water Solubility 
6 g/L
Merck 
14,5705
BRN 
112223
InChIKey
BGRDGMRNKXEXQD-UHFFFAOYSA-N
CAS DataBase Reference
123-33-1(CAS DataBase Reference)
IARC
3 (Vol. 4, Sup 7) 1987
NIST Chemistry Reference
Maleic hydrazide(123-33-1)
EPA Substance Registry System
Maleic hydrazide (123-33-1)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-40-R40-R36/37/38-68
Safety Statements 
26-36-45-36/37/39-S45-S36/37/39-S26
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
UR5950000
Autoignition Temperature
707 °F
TSCA 
Yes
HS Code 
29339990
Hazardous Substances Data
123-33-1(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 3800-6800 mg/kg; dermally in rabbits: >4000 mg/kg (Ben-Dyke)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D119806
Product name
Maleic hydrazide
Purity
ReagentPlus , 99%
Packaging
100g
Price
$67.6
Updated
2024/03/01
Sigma-Aldrich
Product number
45552
Product name
Maleic hydrazide
Purity
PESTANAL
Packaging
250mg
Price
$22.9
Updated
2022/05/15
TCI Chemical
Product number
M0015
Product name
Maleic Hydrazide
Purity
>99.0%(HPLC)(T)
Packaging
25g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
M0015
Product name
Maleic Hydrazide
Purity
>99.0%(HPLC)(T)
Packaging
500g
Price
$221
Updated
2024/03/01
Alfa Aesar
Product number
A12531
Product name
Maleic hydrazide, 97%
Packaging
100g
Price
$67.4
Updated
2023/06/20
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Maleic hydrazide Chemical Properties,Usage,Production

Description

Maleic Hydrazide is a crystalline solid. Molecular weight= 112.10; Freezing/Melting point=292℃ (decomposes at 260℃); also reported as .300℃. Hazard Identification (based on NFPA-704 M Rating System): Health 2, Flammability 1, Reactivity 0. Slightly soluble in cold water; more soluble in hot.

Chemical Properties

Maleic hydrazide is a colorless crystalline solid. Odorless.

Chemical Properties

Maleic hydrazide is a crystalline solid

Uses

Growth regulator used to control the sprouting of potatoes and onions and to prevent sucker development on tobacco, fruits, ornamentals, vines, field crops and in forestry. Also used to control insects in warehouses, storerooms, empty sacks and in animal and poultry houses.

Uses

Maleic Hydrazide is used in plant growth regulator formulations.

Uses

Experimentally in horticulture and agriculture. To control suckering of tobacco. In the synthesis of pyridazine.

Production Methods

Maleic hydrazide is slightly acidic. It is made by treating maleic anhydride with hydrazine hydrate in alcohol.

Definition

ChEBI: Maleic hydrazide is a pyridazinone.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 1873, 1951 DOI: 10.1021/ja01148a537

General Description

Odorless white solid. Sinks in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

3,6-Dihydroxypyridazine can be decomposed by oxidizing agents. 3,6-Dihydroxypyridazine can also be decomposed by strong acids. 3,6-Dihydroxypyridazine forms water-soluble alkali-metal and amine salts. 3,6-Dihydroxypyridazine is slightly acidic and may be titrated as a monobasic acid. Mild oxidation produces a compound which reacts instantly with dienes at -107° F to form crystalline derivatives. 3,6-Dihydroxypyridazine is slightly corrosive to iron and zinc. 3,6-Dihydroxypyridazine is incompatible with pesticides that are highly alkaline in reaction. In the presence of heavy metal and iron, zinc, calcium and magnesium ions, sparingly-soluble salts are formed.

Hazard

Toxic by ingestion. Questionable carcinogen.

Health Hazard

Inhalation of dust causes irritation of nose and throat. Contact with eyes or skin causes irritation. Ingestion has been observed to cause tremors and muscle spasms in test animals.

Fire Hazard

Special Hazards of Combustion Products: Toxic nitrogen oxides are produced.

Agricultural Uses

Herbicide, Plant growth regulator, Fungicide: Banned for use in EU countries. Actively registered for use in the U.S. Maleic hydrazide is a plant growth regulator (sprout inhibitor) and herbicide that is registered for use on tobacco, potatoes, onions, non-bearing citrus, turf, utility and highway rights-of-way, airports, industrial land, lawns, recreational areas, ornamental/shade trees and ornamental plants. Most of the use of maleic hydrazide in the U.S. is on tobacco.

Trade name

BH DOCK KILLER®; BOS MH®; BURTOLIN®; CHEMFORM®; DE-CUT®; DESPROUT D REXEL-SUPER P®; EC 300®; FAIR 30®; FAIR PLUS®; FAIR PS®; MAINTAIN 3®; MALEIN 30®; MALAZIDE®; MH 30®; MH 40®; MH 36 BAYER®; PO-SAN® (with 9H-Fluorene-9-carboxylic acid, 2-chloro-9-hydroxy-, methyl ester)®; REGULOX®; REGULOX W®; REGULOX 50 W®; RETARD®; ROYAL MH 30®; ROYAL SLO-GRO®; SLO-GRO®; SPROUT-STOP®; STUNTMAN®; SUCKER-STUFF®; SUPER DE-SPROUT®; SUPER SPROUT STOP®; VONDALDHYDE®; VONDRAX®

Safety Profile

Moderately toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Can cause chronic liver damage and acute central nervous system effects. When heated to decomposition it emits hghly toxic fumes of NOx See also HYDRAZINE.

Potential Exposure

Maleic hydrazide is a pyridazine/ pyridazinone herbicide, plant growth regulator, and fungicide that is registered for use on tobacco, potatoes, onions, nonbearing citrus, turf, utility and highway rights-of-way, airports, industrial land, lawns, recreational areas, ornamental/ shade trees and ornamental plants. Most of the use of maleic hydrazide in the United States is on tobacco. Banned for use in EU countries. Actively registered for use in the United States

First aid

Skin Contact: Flood all areas of body that have contacted the substance with water. Do not wait to remove contaminated clothing; do it under the water stream. Use soap to help assure removal. Isolate contaminated clothing when removed to prevent contact by others. Eye Contact: Remove any contact lenses at once. Flush eyes well with copious quantities of water or normal saline for at least 2023 min. Seek medical attention. Inhalation: Leave contaminated area immediately; breathe fresh air. Proper respiratory protection must be supplied to any rescuers. If coughing, difficult breathing, or any other symptoms develop, seek medical attention at once, even if symptoms develop many hours after exposure. Ingestion: If convulsions are not present, give a glass or two of water or milk to dilute the substance. Assure that the person’s airway is unobstructed and contact a hospital or poison center immediately for advice on whether or not to induce vomiting.

Carcinogenicity

Mice fed up to 3 mg/kg for 320 ‘days showed no carcinogenic effect when sacrificed at 2 years of age. Mice fed 0, 1000, 3200, and 10,000 ppm in the diet in 23 months showed no oncogenic effect. Rats were fed diets providing doses of 0, 25, 500, or 1000 mg/kg. Occasional increases in tumor incidences were seen, but as these were not consistent between the two sexes and did not achieve statistical significance, they are considered not attributable to maleic hydrazide.
Application of maleic hydrazide to the skin three times a week up to a cumulative dose of 300mg was not carcinogenic . Oral treatment of dogs and rats for 17–28 months resulted in no excess cancer in any tissue or organs. Subcutaneous injections of maleic hydrazide in newborn mice produced a very slight increase in liver tumors, although this finding is generally considered negative. A study in which maleic hydrazide was given subcutaneously to mice (55 mg total over 49 weeks) showed no evidence of a carcinogenic response was seen.

Environmental Fate

Soil. The half-life in soil was reported to be 2–8 weeks (Hartley and Kidd, 1987). When maleic hydrazide was applied to muck, sand and clay at concentrations of 0.7 and 2.7, 1.0 and 3.75 and 0.85 and 3.4 ppm, 86 and 100, 87 and 100 and 47 and 67% degradation yields were obtained, respectively (Hoffman et al., 1962).
Plant. Major plant metabolites include fumaric, succinic and maleic acids (Hartley and Kidd, 1987).
Photolytic. In water, maleic hydrazide showed an absorption maximum at 300 nm indicating direct photolysis should occur (Gore et al., 1971).
Chemical/Physical. Reacts with alkalies and amines forming water-soluble salts (Hartley and Kidd, 1987). Decomposed by oxidizing acids releasing nitrogen (Worthing and Hance, 1991). Decomposes at 260°C (Windholz et al., 1983) releasing toxic fumes of nitrogen oxides (Sax and Lewis, 1987).

storage

Color Code—Green: General storage may be used. Prior to working with this chemical you should be trained on its proper handling and storage. Store in a refrigerator or a cool, dry place.

Shipping

UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Purification Methods

Crystallise the hydrazide from water. Dry it at ~100o over P2O5. [Beilstein 24 III/IV 1186.]

Incompatibilities

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Slightly corrosive to iron and zinc. Maleic hydrazide forms water-soluble alkali-metal and amine salts. It is slightly acidic and may be titrated as a monobasic acid. Mild oxidation produces a compound which reacts instantly with dienes at 277C/ 2 107F to form crystalline derivatives. It is incompatible with pesticides that are highly alkaline in reaction. This chemical is slightly corrosive to iron and zinc. In the presence of heavy metal and iron, zinc, calcium, and magnesium ions, sparingly soluble salts are formed.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Maleic hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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Maleic hydrazide Suppliers

Beijing Anruiqi Chemical Technology Co., Ltd.
Tel
010-5710845 18618313080
Fax
010-69233297
Email
1905569272@qq.com
Country
China
ProdList
274
Advantage
58
Taizhou Chemedir Biopharm-tech. Co., Ltd
Tel
0523-86200218 18994667082
Fax
+86 523-86200613
Email
sale1_cmd@chemedir.com
Country
China
ProdList
110
Advantage
64
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10194
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
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View Lastest Price from Maleic hydrazide manufacturers

Hebei Duling International Trade Co. LTD
Product
Maleic hydrazide 123-33-1
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Ton
Release date
2022-12-20
Hebei Mojin Biotechnology Co., Ltd
Product
Maleic hydrazide 123-33-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-17
Shaanxi Didu New Materials Co. Ltd
Product
Maleic hydrazide 123-33-1
Price
US $1.50/g
Min. Order
1g
Purity
99.0% Min
Supply Ability
100 Tons
Release date
2022-09-19

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