ChemicalBook > CAS DataBase List > JIB-04

JIB-04

Product Name
JIB-04
CAS No.
199596-05-9
Chemical Name
JIB-04
Synonyms
5-chloro-n-[(e)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine;JIB-04;CS-1447;NSC 693627;JIB-04 (E);JIB04/JIB-04;JIB-04, >=98%;NSC693627 (E);JIB-04 USP/EP/BP;JIB-04 (NSC 693627)
CBNumber
CB52664368
Molecular Formula
C17H13ClN4
Formula Weight
308.76
MOL File
199596-05-9.mol
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JIB-04 Property

Boiling point:
472.9±55.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
11.00±0.10(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey
YHHFKWKMXWRVTJ-OQKWZONESA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0808
Product name
JIB-04
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0808
Product name
JIB-04
Purity
≥98% (HPLC)
Packaging
25mg
Price
$479
Updated
2024/03/01
Cayman Chemical
Product number
15338
Product name
JIB-04
Purity
≥95%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
15338
Product name
JIB-04
Purity
≥95%
Packaging
10mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
15338
Product name
JIB-04
Purity
≥95%
Packaging
25mg
Price
$278
Updated
2024/03/01
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JIB-04 Chemical Properties,Usage,Production

Description

JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases?in vitro, in cancer cells and in tumors?in vivo.?IC50?= 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.??Reduces tumor burden and prolongs life in a mouse model.1?Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2?Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3

Uses

JIB-04 is a specific inhibitor of Jumonji demethylases.

Uses

JIB-04 has been used in sulforhodamine B cell growth assay. It has also been used as a control to determine the inhibitory action of ML324 on KDM4A (histone lysine demethylase 4A).

Biochem/physiol Actions

JIB-04 is a selective inihibitor of Jumonji demethylases without inhibiting other α-ketoglutarate-dependent hydroxylases or histone-modifying enzymes including amine oxidase LSD1 (also known as KDM1A), which demethylates histone lysines. JIB-04 is a pan-inhibitor of Jumonji demethylases with JARID1A (KDM5A) being the most sensitive (IC50=230 nM) followed by JMJD2D (IC50=290 nM) and JMJD3 (KDM6B) and JMJD2C (KDM4C) more resistant (IC50 855 and 1100 nM, respectively). JIB-04 selectively inhibited viability of several human cancer cell lines with little toxicity towards normal cells, and also diminished tumor growth in two separate xenograft mouse models.

storage

+4°C

References

1) Wang?et al.?(2013),?A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth; Nature Commun., 4?2035

JIB-04 Preparation Products And Raw materials

Raw materials

Preparation Products

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JIB-04 Suppliers

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View Lastest Price from JIB-04 manufacturers

Career Henan Chemical Co
Product
(E)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE 199596-05-9
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
2kg
Release date
2019-09-05

199596-05-9, JIB-04Related Search:

TYRPHOSTIN AG 879 Cantharidin 17-AAG Geldanamycin Pyridinethione 5-Chloro-2,3-difluoropyridine OXY-PYRION 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS BIX 01294 UNC-1215 GSK J4 HCl ABT 737 5-Carboxy-8-hydroxyquinoline Olaparib

  • JIB-04
  • JIB-04 (NSC 693627)
  • JIB04/JIB-04
  • 5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone
  • (E)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE
  • 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
  • NSC 693627
  • 5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone JIB-04(NSC 693627)
  • JIB-04 5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone
  • (E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine
  • JIB-04 (NSC 693627)(E)
  • JIB-04, >=98%
  • NSC693627 (E)
  • JIB-04 (E)
  • 5-chloro-n-[(e)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine
  • JIB-04 (NSC 693627), 199596-05-9(E)
  • CS-1447
  • JIB-04(NSC 693627), >97%
  • NSC693627;JIB04; JIB 04;NSC-693627;JIB-04;JIB04
  • Methanone, phenyl-2-pyridinyl-, 2-(5-chloro-2-pyridinyl)hydrazone, (E,E)-
  • JIB-04 >=98% (HPLC)
  • JIB-04 USP/EP/BP
  • JIB-04 JHDM Inhibitor VII NSC 693627 JIB04
  • JIB-04,Apoptosis,JIB04,Inhibitor,Histone Demethylase,inhibit
  • 199596-05-9
  • Inhibitors