2-chloro-3-(difluoroMethoxy)pyridine
- Product Name
- 2-chloro-3-(difluoroMethoxy)pyridine
- CAS No.
- 1206977-80-1
- Chemical Name
- 2-chloro-3-(difluoroMethoxy)pyridine
- Synonyms
- 2-Chloro-3-(difluoromthoxy)pyridin;2-chloro-3-(difluoroMethoxy)pyridine;Pyridine, 2-chloro-3-(difluoromethoxy)-
- CBNumber
- CB52664964
- Molecular Formula
- C6H4ClF2NO
- Formula Weight
- 179.55
- MOL File
- 1206977-80-1.mol
2-chloro-3-(difluoroMethoxy)pyridine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Clear, faint lemon
- InChI
- InChI=1S/C6H4ClF2NO/c7-5-4(11-6(8)9)2-1-3-10-5/h1-3,6H
- InChIKey
- HPJAGIYYNJKTOR-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1OC(F)F
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C585398
- Product name
- 2-Chloro-3-(difluoromethoxy)pyridine
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 4H07-7-50
- Product name
- 2-Chloro-3-(difluoromethoxy)pyridine
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 6045DK
- Product name
- 2-Chloro-3-(difluoromethoxy)pyridine
- Packaging
- 250mg
- Price
- $177
- Updated
- 2021/12/16
- Product number
- 4H07-7-50
- Product name
- 2-Chloro-3-(difluoromethoxy)pyridine
- Packaging
- 1g
- Price
- $221
- Updated
- 2021/12/16
- Product number
- 181627
- Product name
- 2-Chloro-3-(difluoromethoxy)pyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $1320
- Updated
- 2021/12/16
2-chloro-3-(difluoroMethoxy)pyridine Chemical Properties,Usage,Production
Synthesis
6636-78-8
1895-39-2
1206977-80-1
The general procedure for the synthesis of 2-chloro-3-difluoromethoxypyridine from 2-chloro-3-hydroxypyridine and sodium difluorochloroacetate was as follows: according to step 3-i of Scheme 3, 2-chloro-3-hydroxypyridine (Compound 1005, 2.0 g, 15.4 mmol, purchased from Aldrich Chemical Co.) was dissolved in 40 mL DMF and 5.0 mL water in a mixed solvent. Sodium chlorodifluoroacetate (4.71 g, 30.9 mmol, purchased from Lancaster Synthesis, Inc.) and anhydrous potassium carbonate (2.56 g, 18.5 mmol) were then added. The reaction mixture was placed in an oil bath and heated at 100 °C for 2 hours. After that, one equivalent of sodium chlorodifluoroacetate and 1.2 equivalents of potassium carbonate were added and heating was continued for 2.0 hours. After completion of the reaction, the reaction mixture was cooled and the volatiles were removed under reduced pressure. The residue was partitioned between brine and ethyl acetate, and the organic phase was washed once with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The product was purified by silica gel column chromatography using a gradient elution from hexane/DCM to DCM to afford 2-chloro-3-(difluoromethoxy)pyridine (compound 1006, 2.0 g, 72% yield) as a white solid.ESMS (M+H) 180; 1H NMR (CDCl3) δ 8.05 (m, 1H), 7.45 (m, 1H), 6.90 (m, 1H), 6.60 (m, 1H). 1H), 6.60 (t, 1H; J = 75 Hz), 4.01 (s, 3H).
References
[1] Patent: WO2010/96389, 2010, A1. Location in patent: Page/Page column 39-40; 42
[2] Patent: WO2010/135014, 2010, A1. Location in patent: Page/Page column 47-49
[3] Patent: WO2011/87776, 2011, A1. Location in patent: Page/Page column 51; 53
[4] Patent: WO2014/207601, 2014, A1. Location in patent: Page/Page column 88
2-chloro-3-(difluoroMethoxy)pyridine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-chloro-3-(difluoroMethoxy)pyridine manufacturers
- Product
- 2-Chloro-3-(difluoromethoxy)pyridine 1206977-80-1
- Price
- US $1.60-9.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
- Product
- 2-chloro-3-(difluoroMethoxy)pyridine 1206977-80-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 2-chloro-3-(difluoromethoxy)pyridine 1206977-80-1
- Price
- US $15.00/Kg/Bag
- Min. Order
- 25Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-11-13