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DESACETYLVINBLASTINEAMIDE

Product Name
DESACETYLVINBLASTINEAMIDE
CAS No.
53643-48-4
Chemical Name
DESACETYLVINBLASTINEAMIDE
Synonyms
VINDESINE;VDS;Fildesin;Eldesine;Compound-112531;VINDESINE SULFATE(RG);DESACETYLVINBLASTINEAMIDE;DESACETYLVINBLASTINEAMIDE USP/EP/BP;Compound 112531:NS C.245467:LY-099094:Hdisine:Fildisin;3-Carbamoyl-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
CBNumber
CB5266881
Molecular Formula
C43H55N5O7
Formula Weight
753.93
MOL File
53643-48-4.mol
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DESACETYLVINBLASTINEAMIDE Property

Melting point:
230-232°
alpha 
D25 +39.4° (c = 1.0 in methanol)
Density 
1.41±0.1 g/cm3(Predicted)
pka
pKa (DMF 66%) 5.39, 7.36; (H2O) 6.04, 7.67(at 25℃)
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Safety

RIDADR 
1544
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
53643-48-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
291976
Product name
Vindesine
Packaging
250mg
Price
$1346
Updated
2021/12/16
AvaChem
Product number
2181B
Product name
Vindesine
Packaging
250mg
Price
$1750
Updated
2021/12/16
AvaChem
Product number
2181B
Product name
Vindesine
Packaging
1g
Price
$4750
Updated
2021/12/16
AvaChem
Product number
2181B
Product name
Vindesine
Packaging
5mg
Price
$65
Updated
2021/12/16
AvaChem
Product number
2181B
Product name
Vindesine
Packaging
10mg
Price
$115
Updated
2021/12/16
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DESACETYLVINBLASTINEAMIDE Chemical Properties,Usage,Production

Originator

Eldisine,Lilly ,France,1980

Uses

Antineoplastic.

Definition

ChEBI: Vindesine is a vinca alkaloid, a methyl ester, an organic heterotetracyclic compound, an organic heteropentacyclic compound, a tertiary alcohol, a tertiary amino compound and a primary carboxamide. It has a role as an antineoplastic agent. It is functionally related to a vincaleukoblastine.

Manufacturing Process

About 10 g of VLB (vincaleucoblastine or simply vinblastine) sulfate were converted by standard procedures to VLB free base. The free base, obtained as a residue after evaporation of the dried ethereal solvent, was dissolved in about 200 ml of anhydrous methanol. Anhydrous liquid ammonia (300 ml) was added, and the reaction mixture sealed and maintained at about 100°C for 60 hours. The reaction vessel was opened, and the contents removed and evaporated to dryness in vacuo. The resulting residue, containing 4-desacetyI VLB C-3 carboxamide, as shown by thin layer chromatography, were combined and the solvent evaporated therefrom in vacuo, yielding asa residue purified 4-desacetyl VLB C-3 carboxamide free base. The NMR and IR spectra of the solid free base confirmed the structure indicated. The free base showed a band in the infrared at 1,687 cm -l , characteristic of the amide function. The molecular weight of the free base determined by mass spectroscopy was 753 which is in agreement with theoretical value calculated for C 43 H 55 N 5 O 7 .

brand name

Eldisine (Lilly).

Therapeutic Function

Antineoplastic

DESACETYLVINBLASTINEAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DESACETYLVINBLASTINEAMIDE Suppliers

Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Eastbang Pharmaceuticals Technology Co., Ltd.
Tel
+86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax
+86 (20) 39218032
Country
China
ProdList
454
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Guangzhou Ciming Biological Technology Co., Ltd.
Tel
020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax
+86 (20)38082986
Country
China
ProdList
830
Advantage
60
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
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View Lastest Price from DESACETYLVINBLASTINEAMIDE manufacturers

Dideu Industries Group Limited
Product
DESACETYLVINBLASTINEAMIDE 53643-48-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-02
Shaanxi Dideu Medichem Co. Ltd
Product
Vindesine 53643-48-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

53643-48-4, DESACETYLVINBLASTINEAMIDERelated Search:


  • VINDESINE
  • 3-(aminocarbonyl)-o(sup4)-deacetyl-3-de(methoxycarbonyl)-vincaleukoblastin
  • 3-(aminocarbonyl)-o(sup4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • DESACETYLVINBLASTINEAMIDE
  • Fildesin
  • Compound 112531:NS C.245467:LY-099094:Hdisine:Fildisin
  • VDS
  • Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-
  • VINDESINE SULFATE(RG)
  • 3-(Aminocarbonyl)-O^<4>^-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • 3-(Aminocarbonyl)-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • 3-Carbamoyl-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • Compound-112531
  • Eldesine
  • DESACETYLVINBLASTINEAMIDE USP/EP/BP
  • 53643-48-4
  • C43H55N5O7