ChemicalBook > CAS DataBase List > DESACETYLVINBLASTINEAMIDE
DESACETYLVINBLASTINEAMIDE
- Product Name
- DESACETYLVINBLASTINEAMIDE
- CAS No.
- 53643-48-4
- Chemical Name
- DESACETYLVINBLASTINEAMIDE
- Synonyms
- VINDESINE;VDS;Fildesin;Eldesine;Compound-112531;VINDESINE SULFATE(RG);DESACETYLVINBLASTINEAMIDE;DESACETYLVINBLASTINEAMIDE USP/EP/BP;Compound 112531：NS C．245467：LY-099094：Hdisine：Fildisin;3-Carbamoyl-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
- CBNumber
- CB5266881
- Molecular Formula
- C43H55N5O7
- Formula Weight
- 753.93
- MOL File
- 53643-48-4.mol
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DESACETYLVINBLASTINEAMIDE Property
- Melting point:
- 230-232°
- alpha
- D25 +39.4° (c = 1.0 in methanol)
- Density
- 1.41±0.1 g/cm3(Predicted)
- pka
- pKa (DMF 66%) 5.39, 7.36; (H2O) 6.04, 7.67(at 25℃)
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Safety
- RIDADR
- 1544
- HazardClass
- 6.1(a)
- PackingGroup
- II
- Hazardous Substances Data
- 53643-48-4(Hazardous Substances Data)
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N-Bromosuccinimide Price
Usbiological
- Product number
- 291976
- Product name
- Vindesine
- Packaging
- 250mg
- Price
- $1346
- Updated
- 2021/12/16
AvaChem
- Product number
- 2181B
- Product name
- Vindesine
- Packaging
- 250mg
- Price
- $1750
- Updated
- 2021/12/16
AvaChem
- Product number
- 2181B
- Product name
- Vindesine
- Packaging
- 1g
- Price
- $4750
- Updated
- 2021/12/16
AvaChem
- Product number
- 2181B
- Product name
- Vindesine
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
AvaChem
- Product number
- 2181B
- Product name
- Vindesine
- Packaging
- 10mg
- Price
- $115
- Updated
- 2021/12/16
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DESACETYLVINBLASTINEAMIDE Chemical Properties,Usage,Production
Originator
Eldisine,Lilly ,France,1980
Uses
Antineoplastic.
Definition
ChEBI: Vindesine is a vinca alkaloid, a methyl ester, an organic heterotetracyclic compound, an organic heteropentacyclic compound, a tertiary alcohol, a tertiary amino compound and a primary carboxamide. It has a role as an antineoplastic agent. It is functionally related to a vincaleukoblastine.
Manufacturing Process
About 10 g of VLB (vincaleucoblastine or simply vinblastine) sulfate were converted by standard procedures to VLB free base. The free base, obtained as a residue after evaporation of the dried ethereal solvent, was dissolved in about 200 ml of anhydrous methanol. Anhydrous liquid ammonia (300 ml) was added, and the reaction mixture sealed and maintained at about 100°C for 60 hours. The reaction vessel was opened, and the contents removed and evaporated to dryness in vacuo. The resulting residue, containing 4-desacetyI VLB C-3 carboxamide, as shown by thin layer chromatography, were combined and the solvent evaporated therefrom in vacuo, yielding asa residue purified 4-desacetyl VLB C-3 carboxamide free base. The NMR and IR spectra of the solid free base confirmed the structure indicated. The free base showed a band in the infrared at 1,687 cm -l , characteristic of the amide function. The molecular weight of the free base determined by mass spectroscopy was 753 which is in agreement with theoretical value calculated for C 43 H 55 N 5 O 7 .
brand name
Eldisine (Lilly).
Therapeutic Function
Antineoplastic
DESACETYLVINBLASTINEAMIDE Preparation Products And Raw materials
Raw materials
1-Butyl nitrite
Vinblastine sulfate
Dichloromethane
HYDRAZINE
Methanol
Triphenylphosphine
Vincristine sulfate
Ammonia
Preparation Products
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View Lastest Price from DESACETYLVINBLASTINEAMIDE manufacturers
Dideu Industries Group Limited
- Product
- DESACETYLVINBLASTINEAMIDE 53643-48-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-02
Shaanxi Dideu Medichem Co. Ltd
- Product
- Vindesine 53643-48-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 ton
- Release date
- 2020-04-30
53643-48-4, DESACETYLVINBLASTINEAMIDERelated Search:
Vinblastine sulfate
Vincristine
Dexrazoxane
Vinorelbine tartrate
Vindesine sulfate
1,3,3,5,5-PENTAMETHYLCYCLOHEXANOL
TRIMETHYLHEXAMETHYLENEDIAMINE
TRANS-2-AMINOMETHYL-1-CYCLOHEXANOL
DESACETYLVINBLASTINEAMIDE
P-(TRANS-4-HYDROXYCYCLOHEXYL)PHENOL
(2-METHOXY-5-METHYLPHENYL)ACETIC ACID
TRANS-2-HYDROXY-1-CYCLOHEXANECARBOXAMIDE
CIS-2-AMINO-1-CYCLOHEXANECARBOXAMIDE
1-(2-(2-Methyl-1H-indol-3-yl)ethyl)-3-piperidinol
2-METHOXY-5-METHYL-BENZENEACETIC ACID METHYL ESTER
Propionic acid, 2-(4-(isopropylamino)phenyl)-
2-Methyl-3-(2-(3-methyl-1-piperidinyl)ethyl)-1H-indole
2,4-BIS(1-METHYLBUTYL)PHENOL