ChemicalBook > CAS DataBase List > (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol

Product Name: (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol
CAS No.: 1374639-77-6
Chemical Name: (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol
Synonyms: EOS-60968;Ribociclib Intermediate 2;(Chloro Hydroxymethyl Impurity);Ribociclib Chloro Hydroxymethyl IMP;Ribociclib Chloro Hydroxymethyl Impurity;(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin;2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-Methanol;(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)meth...;7H-Pyrrolo[2,3-d]pyrimidine-6-methanol, 2-chloro-7-cyclopentyl-;(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol
CBNumber: CB52671067
Molecular Formula: C12H14ClN3O
Formula Weight: 251.71
MOL File: 1374639-77-6.mol

Less

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol Property

Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 14.09±0.10(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C12H14ClN3O/c13-12-14-6-8-5-10(7-17)16(11(8)15-12)9-3-1-2-4-9/h5-6,9,17H,1-4,7H2
InChIKey: ADHCEFBFOBDYEC-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C2C=C(CO)N(C3CCCC3)C2=N1

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: C587363
Product name: (2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
Packaging: 500mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-B1534
Product name: 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol
Purity: >98.0%
Packaging: 5g
Price: $194
Updated: 2021/12/16

ChemScene

Product number: CS-B1534
Product name: 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol
Purity: >98.0%
Packaging: 10g
Price: $323
Updated: 2021/12/16

ChemScene

Product number: CS-B1534
Product name: 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol
Purity: >98.0%
Packaging: 250mg
Price: $53
Updated: 2021/12/16

ChemScene

Product number: CS-B1534
Product name: 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol
Purity: >98.0%
Packaging: 1g
Price: $65
Updated: 2021/12/16

Less

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol Chemical Properties,Usage,Production

Synthesis

1374639-76-5

1374639-77-6

General procedure for the synthesis of 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-D]pyrimidine-6-methanol from 3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol: Compound (3) (5 g, 19.9 mmol) was dissolved in THF (50 mL) under the protection of nitrogen and stirred at 29 °C. To this solution was slowly added 1.0 M tetrabutylammonium fluoride in THF solution (45 mL) and subsequently the reaction mixture was heated to 60 °C and the progress of the reaction was monitored by TLC. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was dissolved in 2-propanol (10 mL) and stirred at 50 °C until complete dissolution. The resulting clarified solution was cooled to 29 °C, water (75 mL) was added slowly and stirring was continued for 4 hours. The precipitated solid was collected by filtration, washed with water and dried under vacuum at 50 °C to give compound (4) as a brown solid in 68% yield, melting point 173-175 °C. 1H NMR (400 MHz, DMSO-d6) δ: 1.64-1.65 (m, 2H, -CH2), 1.98-2.03 (m, 4H, -CH2), 2.22- 2.29 (m, 2H, -CH2), 4.67 (d, 2H, J=5.12Hz, -CH2OH), 4.87-4.89 (m, 1H, -NH-CH-), 5.52 (s, 1H, -CH2OH), 6.55 (s, 1H, Ar-H), 8.82 (s, 1H, Ar-H).13C NMR (75.46 MHz, DMSO-d6) δ: 152.3, 151.5, 150.9, 144.7, 118.21, 98.5, 56.4, 52.3, 30.7, 24.9. ESI-HRMS (m/z): the calculated value of [M+] for C12H14ClN3O was 251.7129 and the measured value was 251.8001.

References

[1] Combinatorial Chemistry and High Throughput Screening, 2017, vol. 20, # 8, p. 703 - 712
[2] Patent: US2012/115878, 2012, A1. Location in patent: Page/Page column 7
[3] Patent: WO2018/51280, 2018, A1. Location in patent: Page/Page column 20

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol Suppliers

China 122 India 2 United States 3 Global 127

Suzhou Carbonwell Pharma-Tech Co., Ltd

Tel: 0512-0512-88981216 13776013740
Email: 1320558046@qq.com
Country: China
ProdList: 72
Advantage: 58

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60189726 18812034280
Fax: 86-22-60979672
Email: 188120342808@163.com
Country: China
ProdList: 142
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Changzhou Joyous Chemical Co., Ltd.

Tel: 0519-85607258 13912342323;
Fax: 0519-85607278
Email: sales@joyouschem.com
Country: China
ProdList: 294
Advantage: 60

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 603
Advantage: 58

Wuhan Taiyicheng Biopharmaceutical Co., Ltd.

Tel: 027-88320699
Fax: 027-88320962
Email: tycshyy@126.com
Country: China
ProdList: 297
Advantage: 66

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 21-33585366 13311639313
Fax: +86-21-34979012
Email: sales@shyrchem.com
Country: China
ProdList: 806
Advantage: 55

Acesys Pharmatech

Tel: 18860950986
Email: tangmanman@zenjipharma.com
Country: China
ProdList: 1733
Advantage: 55

Suli Pharmaceutical Technology Co., Ltd.

Tel: 021-58086325-8060 13636568474
Fax: 021-51972827
Email: yingjie.zhang@suli.com
Country: China
ProdList: 100
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu Climb Pharmaceutical Technology Co., Ltd.

Tel: 028-87608726 13540107218
Fax: 028-87608725
Email: sales@cdclimb.com
Country: China
ProdList: 104
Advantage: 58

Shanghai SE Pharm Co., Ltd

Tel: 18112588827
Email: sales4@sepharm.com.cn
Country: China
ProdList: 285
Advantage: 60

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: 52513593@qq.com
Country: China
ProdList: 2331
Advantage: 50

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

FarmaSino Pharmaceuticals (Anhui) Co.,Ltd.

Tel: +86-18512541987
Fax: 0555-5963572
Email: hll@farmasino.com
Country: China
ProdList: 241
Advantage: 60

Intelligence Pharm Science(Shanghai) Co., Ltd.

Tel: 021-57898186
Fax: 021-37699262
Country: China
ProdList: 449
Advantage: 55

Anqing CHICO Pharmaceutical Co., Ltd.

Tel: 13585175604 13057662806
Fax: +86-25-52261140
Email: sales@chicopharm.com
Country: China
ProdList: 500
Advantage: 65

Shanghai Rochi Pharmaceutical Co., Ltd.

Tel: 021-38751876 15000076078
Fax: 021-50275764
Email: Info@rochipharma.com
Country: China
ProdList: 611
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83991130 18627774460
Fax: 027-83991130
Email: 1718093273@QQ.COM
Country: China
ProdList: 1676
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@yongstandards.com
Country: China
ProdList: 10000
Advantage: 55

Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2944
Advantage: 58

Shanghai CR Corporation Limited

Tel: 13062833949; 4006653949 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 9755
Advantage: 58

Adobe Chem Co., Ltd.

Tel: 2332782371
Fax: QQ: 2332782371
Email: adobechem@qq.com
Country: China
ProdList: 7980
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Wuhan NewBaiChuan Pharmaceutical Co., Ltd.

Tel: 027-50476178
Fax: QQ644526144
Email: 644526144@qq.com
Country: China
ProdList: 418
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

NANJING ZENJI PHARMACEUTICALS

Tel: 025-58231105-8151
Fax: 025-83172562
Email: marketing@zenjipharma.com
Country: China
ProdList: 420
Advantage: 58

Abydos Scientific

Tel: 025-84767922 18936879710
Email: sales@abydoscientific.com
Country: China
ProdList: 1002
Advantage: 58

Wuhan Xinbaichuan Pharmaceutical Technology Co., Ltd.

Tel: 027-50478167
Fax: QQ 252994272
Email: 252994272@qq.com
Country: China
ProdList: 277
Advantage: 58

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Shanxi Xuanran Import and Export Trade Co., Ltd.

Tel: +8617735180244
Email: mike_yan@xuanranglobal.com
Country: CHINA
ProdList: 4017
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Hangzhou Cyanochem Co., Ltd.

Tel: +86 17788583750
Fax: +86 571 85220831
Email: sales@cyanochem.com
Country: CHINA
ProdList: 281
Advantage: 58

Less

View Lastest Price from (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol 1374639-77-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-03

Shaanxi Dideu New Materials Co. Ltd

Product: (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol 1374639-77-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-07

Career Henan Chemical Co

Product: (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol 1374639-77-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-09

1374639-77-6, (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)MethanolRelated Search:

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-Methanol

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol

EOS-60968

Ribociclib Intermediate 2

7H-Pyrrolo[2,3-d]pyrimidine-6-methanol, 2-chloro-7-cyclopentyl-

Ribociclib Chloro Hydroxymethyl IMP

2-Chloro-7-cyclopentyl-6-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidine

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin

Ribociclib Chloro Hydroxymethyl Impurity

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)meth...

(Chloro Hydroxymethyl Impurity)

1374639-77-6