ChemicalBook > CAS DataBase List > BroMosporine

BroMosporine

Product Name
BroMosporine
CAS No.
1619994-69-2
Chemical Name
BroMosporine
Synonyms
CS-921;BroMosporine;BroMosporine USP/EP/BP;Bromosporine, 10 mM in DMSO;KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4;N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate;ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate;Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester;11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase
CBNumber
CB52676961
Molecular Formula
C17H20N6O4S
Formula Weight
404.44
MOL File
1619994-69-2.mol
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BroMosporine Property

Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 25 mg/ml)
pka
6.21±0.46(Predicted)
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0992
Product name
Bromosporine
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$178
Updated
2025/07/31
Cayman Chemical
Product number
14119
Product name
Bromosporine
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
14119
Product name
Bromosporine
Purity
≥98%
Packaging
5mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
14119
Product name
Bromosporine
Purity
≥98%
Packaging
10mg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
14119
Product name
Bromosporine
Purity
≥98%
Packaging
25mg
Price
$353
Updated
2024/03/01
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BroMosporine Chemical Properties,Usage,Production

Description

Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1?Bromosporine was able to reactivate HIV-1 replication in different latency models.2

Uses

Bromosporine is a broad spectrum inhibitor for bromodomains.

in vivo

Bromosporine (100 mg/kg; i.p.; daily for 10 days) shows better antitumor activity than individual when co-treated with 5-Fluorouracil.html" class="link-product" target="_blank">5-FU (HY-90006)[1].

Animal Model:Female BALB/c nude mice (5-6 weeks; injected with 1?×?106?cells/100?μL of HT116?cells)[1]
Dosage:100 mg/kg
Administration:i.p.; daily for 10 days
Result:Exhibited better antitumor activity than individual Bromosporine or 5-FU (HY-90006) when co-treated with the two agent.

target

bromodomain

IC 50

HIV-1

storage

Store at +4°C

References

[1] SARAH PICAUD. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia[J]. Science Advances, 2016, 2 10. DOI:10.1126/sciadv.1600760
[2] HANYU PAN. The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells.[J]. Oncotarget, 2017: 94104-94116. DOI:10.18632/oncotarget.21585

BroMosporine Preparation Products And Raw materials

Raw materials

Preparation Products

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BroMosporine Suppliers

China 90 India 1 United Kingdom 1 United States 17 Global 109
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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info@adooq.com
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United States
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
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United States
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Target molecule Corp.
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857-239-0968
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857-239-8801
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service1@targetmol.com
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United States
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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United States
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
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Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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United States
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ApexBio Technology
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sales@apexbt.com
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BOC Sciences
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16314854226
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United States
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Riedel-de Haen AG
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Focus Biomolecules
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Cayman Chemical Company
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cayman@caymanchem.com
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United States Biological
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MedChemExpress
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View Lastest Price from BroMosporine manufacturers

Career Henan Chemical Co
Product
BroMosporine 1619994-69-2
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

1619994-69-2, BroMosporineRelated Search:

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  • BroMosporine
  • ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate
  • N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
  • CS-921
  • Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester
  • BroMosporine USP/EP/BP
  • 11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase
  • KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4
  • Bromosporine, 10 mM in DMSO
  • 1619994-69-2
  • Inhibitors
  • API