ChemicalBook > CAS DataBase List > 2-METHOXYESTRADIOL

2-METHOXYESTRADIOL

Product Name
2-METHOXYESTRADIOL
CAS No.
362-07-2
Chemical Name
2-METHOXYESTRADIOL
Synonyms
2-Methoxy 17β-Estradiol;2-ME2;Panzem;2-MeOE2;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-METHOXYESTRADIOL;2-METHOXYOESTRADIOL;2-Methoxy-β-estradiol
CBNumber
CB5268052
Molecular Formula
C19H26O3
Formula Weight
302.41
MOL File
362-07-2.mol
More
Less

2-METHOXYESTRADIOL Property

Melting point:
188-190°C
Boiling point:
464.4±45.0 °C(Predicted)
Density 
1.178±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: 10 mg/mL
form 
crystalline
pka
10.29±0.60(Predicted)
color 
light yellow
λmax
286nm(EtOH)(lit.)
InChIKey
CQOQDQWUFQDJMK-SSTWWWIQSA-N
CAS DataBase Reference
362-07-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
T,Xi,N
Risk Statements 
23/24/25-36/37/38-48-61-60-46-45-51/53
Safety Statements 
22-26-36/37/39-45-53-36-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
RTECS 
KG7537500
HS Code 
2937.23.5050
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H350May cause cancer

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
454180
Product name
2-Methoxyestradiol
Packaging
10mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
454180
Product name
2-Methoxyestradiol
Packaging
50mg
Price
$417
Updated
2024/03/01
TCI Chemical
Product number
M2530
Product name
2-Methoxy-β-estradiol
Purity
>97.0%(GC)
Packaging
25mg
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
M2530
Product name
2-Methoxy-β-estradiol
Purity
>97.0%(GC)
Packaging
100mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
13021
Product name
2-Methoxyestradiol
Purity
≥95%
Packaging
5mg
Price
$31
Updated
2024/03/01
More
Less

2-METHOXYESTRADIOL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a

Uses

A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly

Uses

2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.

Uses

2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.

Uses

2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

Definition

ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.

Biological Activity

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

2-METHOXYESTRADIOL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-METHOXYESTRADIOL Suppliers

Americas 1 Canada 2 China 211 Europe 1 Germany 1 India 5 Japan 2 Poland 1 Switzerland 1 United Kingdom 4 United States 30 Global 259
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19185
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8835
Advantage
52
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Wisdom Pharmaceutical Co., Ltd.
Tel
0086-15189180296
Fax
0086-513-81292226
Email
l_xu@wisdompharma.com
Country
China
ProdList
221
Advantage
60
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18021050169
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
GIHI CHEMICALS CO.,LTD
Tel
0086-571-86217390
Fax
0086-571-86217391
Email
Sales@gihichem.com
Country
China
ProdList
860
Advantage
58
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18097
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Watson Biotechnology Co.,Ltd
Tel
027-59207879 1972026995 18140587686
Fax
QQ：1972026995
Email
sales@3600chem.com
Country
China
ProdList
4657
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
1005
Advantage
55
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
6905
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Jinan Putubio Tech Co., Ltd.
Tel
+86 (531) 8099-2215
Fax
+86 (531) 8099-2215
Email
putubio@outlook.com
Country
China
ProdList
1261
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5010
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29764
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Guangzhou Kafen Biotech Co.,Ltd
Tel
18029243487 2355327168
Fax
020-31121510
Email
gy@yccreate.com
Country
China
ProdList
4749
Advantage
55
Nanjing Klender Bio-Technology Co., Ltd.
Tel
025-52343882 18112933882
Fax
025-52343882
Email
sales@kldbio.com
Country
China
ProdList
2019
Advantage
55
Wuhan Zonvsicom chemicals Co.,Ltd.
Tel
15623071665
Fax
027-59257948
Email
sales@zvsicom.com
Country
China
ProdList
299
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28805
Advantage
58
More
Less

View Lastest Price from 2-METHOXYESTRADIOL manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
2-METHOXYESTRADIOL 362-07-2
Price
US $0.00/KG
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20TON
Release date
2021-06-03
Wuhan Senwayer Century Chemical Co.,Ltd
Product
2-METHOXYESTRADIOL 362-07-2
Price
US $540.00/gram
Min. Order
100gram
Purity
99% HPLC
Supply Ability
20 tons
Release date
2022-10-21
Hebei Kangcang new material Technology Co., LTD
Product
2-Methoxyestradiol 362-07-2
Price
US $20.00-10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20
Release date
2024-03-20

362-07-2, 2-METHOXYESTRADIOLRelated Search:

2-METHOXYESTRADIOL Estradiol β-Estradiol 2-METHOXY-17BETA-ESTRADIOL-1,4,16,16,17-D5 2-METHOXYESTRADIOL [6,7-3H] 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 2-METHYL ETHER 3-ACETATE 17-ETHYLENEKETAL 3-Methoxyestradiol 1,3,5(10)-ESTRATRIEN-2,3,16ALPHA,17BETA-TETROL 2-METHYL ETHER 2-HYDROXYESTRADIOL 17α-Iodovinyl-11β-methoxyestradiol(E) 16-methoxyestradiol 16-iodo-11-methoxyestradiol 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-ETHYL ETHER (9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ACETIC ACID (13S,17S)-3-HYDROXY-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-YL ESTER 17 alpha-iodovinyl-11 beta-methoxyestradiol 2-METHOXYESTRADIOL 3-METHYL ETHER 17-iodovinyl-11-methoxyestradiol-3-methyl ether 1,3,5(10)-ESTRATRIEN-2,3,15-BETA, 16-BETA, 17-BETA-PENTOL 2-METHYL ETHER

  • 2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS
  • 2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
  • 2-Hydroxyestradiol 2-Methyl Ether
  • 2-Methoxy-17b-estradiol
  • 2-Methoxyestra-1,3,5(10)-triene-3,17b-diol
  • NSC 659853
  • Panzem
  • 2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
  • 2-METHOXYOESTRADIOL
  • 2-METHOXYESTRADIOL 98+%
  • 2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
  • (17)-2-Methoxy-estra-1,3,5(10)-triene-3,17-diol
  • 2-Methoxy-17-estradiol
  • 2-Methoxyestra-1,3,5(10)-triene-3,17-diol
  • (17B)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIOL
  • 2-Methoxy-beta-estradiol
  • 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether
  • 2-MeOE2
  • 2-methoxy-17beta-estradiol
  • 2-Methoxyestradiol (NSC-659853)
  • 2-methoxy-beta-oestradiol
  • 1,3,5(10)-Estratriene-2,3,17β-triol 2-methyl ether, 2-Methoxy-estra-1,3,5(10)-triene-3,17β-diol
  • 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
  • (17β)-2-Methoxyestradiol
  • 17β-2-Methoxyestradiol
  • 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
  • 7-Methoxyestradiol
  • 2-Methoxyestradiol,1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-es
  • 2-Methoxy-[13C,2H3]-estradiol
  • 2-ME2
  • 2-Methoxyestradiol(2-MeOE2)
  • (8R,9S,13S,14S,17S)-2-Methoxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
  • 2,3,17BETA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE 2-METHYL ETHER
  • 3,17BETA-DIHYDROXY-2-METHOXY-1,3,5[10]-ESTRATRIENE
  • 2-METHOXY-3,17BETA-DIHYDROXYESTRA-1,3,5(10)-TRIENE
  • 2-METHOXY-ESTRA-1,3,5(10)-TRIENE-3,17BETA-DIOL
  • 2-METHOXYESTRADIOL
  • 1,3,5(10)-ESTRATRIENE-2,3,17BETA-TRIOL 2-METHYL ETHER
  • 1,3,5[10]-ESTRATRIENE-2,3,17-TRIOL 2-METHYL ETHER
  • 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER
  • 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem
  • 2-Methoxy-β-estradiol&gt
  • Methoxy estradiol
  • Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17β)-
  • 2-Methoxy 17β-Estradiol
  • 2-METHOXYESTRADIOL USP/EP/BP
  • 2-Methoxyestradiol (2MeOE2, NSC659853, 2ME2)
  • 362-07-2 2-METHOXYESTRADIOL
  • 2-Methoxy-β-estradiol
  • 2-Methoxy-beta-estradiol 2-Methoxyestradiol
  • 1, 3, 5(10)-ESTRATRIEN-2, 3, 17β-TRIOL 2-METHYL ETHER
  • (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
  • 2-Methoxyestradiol, antitumor and antiangiogenic agent
  • 362-07-2
  • 363-07-2
  • Steroid Hormones
  • Other Steroid Products
  • META - METH