ChemicalBook > CAS DataBase List > 2-METHOXYESTRADIOL

2-METHOXYESTRADIOL

Product Name
2-METHOXYESTRADIOL
CAS No.
362-07-2
Chemical Name
2-METHOXYESTRADIOL
Synonyms
2-Methoxy 17β-Estradiol;2-ME2;Panzem;2-MeOE2;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-METHOXYESTRADIOL;2-METHOXYOESTRADIOL;2-Methoxy-β-estradiol
CBNumber
CB5268052
Molecular Formula
C19H26O3
Formula Weight
302.41
MOL File
362-07-2.mol
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2-METHOXYESTRADIOL Property

Melting point:
188-190°C
Boiling point:
464.4±45.0 °C(Predicted)
Density 
1.178±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: 10 mg/mL
form 
crystalline
pka
10.29±0.60(Predicted)
color 
light yellow
λmax
286nm(EtOH)(lit.)
InChIKey
CQOQDQWUFQDJMK-SSTWWWIQSA-N
CAS DataBase Reference
362-07-2(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi,N
Risk Statements 
23/24/25-36/37/38-48-61-60-46-45-51/53
Safety Statements 
22-26-36/37/39-45-53-36-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
RTECS 
KG7537500
HS Code 
2937.23.5050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H350May cause cancer

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
454180
Product name
2-Methoxyestradiol
Packaging
10mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
454180
Product name
2-Methoxyestradiol
Packaging
50mg
Price
$417
Updated
2024/03/01
TCI Chemical
Product number
M2530
Product name
2-Methoxy-β-estradiol
Purity
>97.0%(GC)
Packaging
25mg
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
M2530
Product name
2-Methoxy-β-estradiol
Purity
>97.0%(GC)
Packaging
100mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
13021
Product name
2-Methoxyestradiol
Purity
≥95%
Packaging
5mg
Price
$31
Updated
2024/03/01
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2-METHOXYESTRADIOL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a

Uses

A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly

Uses

2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.

Uses

2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.

Uses

2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

Definition

ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.

Biological Activity

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

2-METHOXYESTRADIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHOXYESTRADIOL Suppliers

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View Lastest Price from 2-METHOXYESTRADIOL manufacturers

Hebei Kangcang new material Technology Co., LTD
Product
2-Methoxyestradiol 362-07-2
Price
US $20.00-10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20
Release date
2024-03-20
Hebei Kangcang new material Technology Co., LTD
Product
2-Methoxyestradiol 362-07-2
Price
US $9.00-60.00/g
Min. Order
10g
Purity
99%
Supply Ability
10 tons
Release date
2024-03-22
Hong Kong Excellence Biotechnology Co., Ltd.
Product
2-Methoxyestradiol 362-07-2
Price
US $100.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-10-12

362-07-2, 2-METHOXYESTRADIOLRelated Search:

2-METHOXYESTRADIOL Estradiol β-Estradiol 2-METHOXY-17BETA-ESTRADIOL-1,4,16,16,17-D5 2-METHOXYESTRADIOL [6,7-3H] 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 2-METHYL ETHER 3-ACETATE 17-ETHYLENEKETAL 3-Methoxyestradiol 1,3,5(10)-ESTRATRIEN-2,3,16ALPHA,17BETA-TETROL 2-METHYL ETHER 2-HYDROXYESTRADIOL 17α-Iodovinyl-11β-methoxyestradiol(E) 16-methoxyestradiol 16-iodo-11-methoxyestradiol 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-ETHYL ETHER (9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ACETIC ACID (13S,17S)-3-HYDROXY-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-YL ESTER 17 alpha-iodovinyl-11 beta-methoxyestradiol 2-METHOXYESTRADIOL 3-METHYL ETHER 17-iodovinyl-11-methoxyestradiol-3-methyl ether 1,3,5(10)-ESTRATRIEN-2,3,15-BETA, 16-BETA, 17-BETA-PENTOL 2-METHYL ETHER

  • 2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS
  • 2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
  • 2-Hydroxyestradiol 2-Methyl Ether
  • 2-Methoxy-17b-estradiol
  • 2-Methoxyestra-1,3,5(10)-triene-3,17b-diol
  • NSC 659853
  • Panzem
  • 2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
  • 2-METHOXYOESTRADIOL
  • 2-METHOXYESTRADIOL 98+%
  • 2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
  • (17)-2-Methoxy-estra-1,3,5(10)-triene-3,17-diol
  • 2-Methoxy-17-estradiol
  • 2-Methoxyestra-1,3,5(10)-triene-3,17-diol
  • (17B)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIOL
  • 2-Methoxy-beta-estradiol
  • 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether
  • 2-MeOE2
  • 2-methoxy-17beta-estradiol
  • 2-Methoxyestradiol (NSC-659853)
  • 2-methoxy-beta-oestradiol
  • 1,3,5(10)-Estratriene-2,3,17β-triol 2-methyl ether, 2-Methoxy-estra-1,3,5(10)-triene-3,17β-diol
  • 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
  • (17β)-2-Methoxyestradiol
  • 17β-2-Methoxyestradiol
  • 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
  • 7-Methoxyestradiol
  • 2-Methoxyestradiol,1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-es
  • 2-Methoxy-[13C,2H3]-estradiol
  • 2-ME2
  • 2-Methoxyestradiol(2-MeOE2)
  • (8R,9S,13S,14S,17S)-2-Methoxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
  • 2,3,17BETA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE 2-METHYL ETHER
  • 3,17BETA-DIHYDROXY-2-METHOXY-1,3,5[10]-ESTRATRIENE
  • 2-METHOXY-3,17BETA-DIHYDROXYESTRA-1,3,5(10)-TRIENE
  • 2-METHOXY-ESTRA-1,3,5(10)-TRIENE-3,17BETA-DIOL
  • 2-METHOXYESTRADIOL
  • 1,3,5(10)-ESTRATRIENE-2,3,17BETA-TRIOL 2-METHYL ETHER
  • 1,3,5[10]-ESTRATRIENE-2,3,17-TRIOL 2-METHYL ETHER
  • 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER
  • 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem
  • 2-Methoxy-β-estradiol&gt
  • Methoxy estradiol
  • Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17β)-
  • 2-Methoxy 17β-Estradiol
  • 2-METHOXYESTRADIOL USP/EP/BP
  • 2-Methoxyestradiol (2MeOE2, NSC659853, 2ME2)
  • 362-07-2 2-METHOXYESTRADIOL
  • 2-Methoxy-β-estradiol
  • 2-Methoxy-beta-estradiol 2-Methoxyestradiol
  • 1, 3, 5(10)-ESTRATRIEN-2, 3, 17β-TRIOL 2-METHYL ETHER
  • (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
  • 362-07-2
  • 363-07-2
  • Steroid Hormones
  • Other Steroid Products
  • META - METH
  • Hormones