2-METHOXYESTRADIOL

Product Name: 2-METHOXYESTRADIOL
CAS No.: 362-07-2
Chemical Name: 2-METHOXYESTRADIOL
Synonyms: 2-Methoxy 17β-Estradiol;2-ME2;Panzem;2-MeOE2;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-METHOXYESTRADIOL;2-METHOXYOESTRADIOL;2-Methoxy-β-estradiol
CBNumber: CB5268052
Molecular Formula: C19H26O3
Formula Weight: 302.41
MOL File: 362-07-2.mol

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2-METHOXYESTRADIOL Property

Melting point:: 188-190°C
Boiling point:: 464.4±45.0 °C(Predicted)
Density: 1.178±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: 10 mg/mL
form: crystalline
pka: 10.29±0.60(Predicted)
color: light yellow
λmax: 286nm(EtOH)(lit.)
InChIKey: CQOQDQWUFQDJMK-SSTWWWIQSA-N
CAS DataBase Reference: 362-07-2(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi,N
Risk Statements: 23/24/25-36/37/38-48-61-60-46-45-51/53
Safety Statements: 22-26-36/37/39-45-53-36-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: KG7537500
HS Code: 2937.23.5050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H350May cause cancer

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 454180
Product name: 2-Methoxyestradiol
Packaging: 10mg
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: 454180
Product name: 2-Methoxyestradiol
Packaging: 50mg
Price: $417
Updated: 2024/03/01

TCI Chemical

Product number: M2530
Product name: 2-Methoxy-β-estradiol
Purity: >97.0%(GC)
Packaging: 25mg
Price: $44
Updated: 2024/03/01

TCI Chemical

Product number: M2530
Product name: 2-Methoxy-β-estradiol
Purity: >97.0%(GC)
Packaging: 100mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 13021
Product name: 2-Methoxyestradiol
Purity: ≥95%
Packaging: 5mg
Price: $31
Updated: 2024/03/01

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2-METHOXYESTRADIOL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a

Uses

A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly

Uses

2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.

Uses

2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.

Uses

2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

Definition

ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.

Biological Activity

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

2-METHOXYESTRADIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHOXYESTRADIOL Suppliers

Americas 1 Canada 2 China 203 Europe 1 Germany 1 India 5 Japan 2 Poland 1 Switzerland 1 United Kingdom 4 United States 29 Global 250

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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3B Pharmachem (Wuhan) International Co.,Ltd.

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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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Email: Sales-CN@TCIchemicals.com
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Nanjing Chemlin Chemical Co., Ltd

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XiaoGan ShenYuan ChemPharm co,ltd

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Jinan Trio PharmaTech Co., Ltd.

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Syntechem Co.,Ltd

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Wisdom Pharmaceutical Co., Ltd.

Tel: 0086-15189180296
Fax: 0086-513-81292226
Email: l_xu@wisdompharma.com
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ProdList: 221
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View Lastest Price from 2-METHOXYESTRADIOL manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: 2-METHOXYESTRADIOL 362-07-2
Price: US $540.00/gram
Min. Order: 100gram
Purity: 99% HPLC
Supply Ability: 20 tons
Release date: 2022-10-21

Hong Kong Excellence Biotechnology Co., Ltd.

Product: 2-Methoxyestradiol 362-07-2
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20tons
Release date: 2023-10-12

Hebei Kangcang new material Technology Co., LTD

Product: 2-Methoxyestradiol 362-07-2
Price: US $20.00-10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20
Release date: 2024-03-20

362-07-2, 2-METHOXYESTRADIOLRelated Search:

2-METHOXYESTRADIOL Estradiol β-Estradiol 2-METHOXY-17BETA-ESTRADIOL-1,4,16,16,17-D5 2-METHOXYESTRADIOL [6,7-3H] 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 2-METHYL ETHER 3-ACETATE 17-ETHYLENEKETAL 3-Methoxyestradiol 1,3,5(10)-ESTRATRIEN-2,3,16ALPHA,17BETA-TETROL 2-METHYL ETHER 2-HYDROXYESTRADIOL 17α-Iodovinyl-11β-methoxyestradiol(E) 16-methoxyestradiol 16-iodo-11-methoxyestradiol 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-ETHYL ETHER (9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ACETIC ACID (13S,17S)-3-HYDROXY-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-YL ESTER 17 alpha-iodovinyl-11 beta-methoxyestradiol 2-METHOXYESTRADIOL 3-METHYL ETHER 17-iodovinyl-11-methoxyestradiol-3-methyl ether 1,3,5(10)-ESTRATRIEN-2,3,15-BETA, 16-BETA, 17-BETA-PENTOL 2-METHYL ETHER

2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS

2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL

2-Hydroxyestradiol 2-Methyl Ether

2-Methoxy-17b-estradiol

2-Methoxyestra-1,3,5(10)-triene-3,17b-diol

NSC 659853

Panzem

2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

2-METHOXYOESTRADIOL

2-METHOXYESTRADIOL 98+%

2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL

(17)-2-Methoxy-estra-1,3,5(10)-triene-3,17-diol

2-Methoxy-17-estradiol

2-Methoxyestra-1,3,5(10)-triene-3,17-diol

(17B)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIOL

2-Methoxy-beta-estradiol

2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether

2-MeOE2

2-methoxy-17beta-estradiol

2-Methoxyestradiol (NSC-659853)

2-methoxy-beta-oestradiol

1,3,5(10)-Estratriene-2,3,17β-triol 2-methyl ether, 2-Methoxy-estra-1,3,5(10)-triene-3,17β-diol

1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene

(17β)-2-Methoxyestradiol

17β-2-Methoxyestradiol

3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene

7-Methoxyestradiol

2-Methoxyestradiol,1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-es

2-Methoxy-[13C,2H3]-estradiol

2-ME2

2-Methoxyestradiol(2-MeOE2)

(8R,9S,13S,14S,17S)-2-Methoxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

2,3,17BETA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE 2-METHYL ETHER

3,17BETA-DIHYDROXY-2-METHOXY-1,3,5[10]-ESTRATRIENE

2-METHOXY-3,17BETA-DIHYDROXYESTRA-1,3,5(10)-TRIENE

2-METHOXY-ESTRA-1,3,5(10)-TRIENE-3,17BETA-DIOL

2-METHOXYESTRADIOL

1,3,5(10)-ESTRATRIENE-2,3,17BETA-TRIOL 2-METHYL ETHER

1,3,5[10]-ESTRATRIENE-2,3,17-TRIOL 2-METHYL ETHER

1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER

2-Methoxyestradiol - CAS 362-07-2 - Calbiochem

2-Methoxy-β-estradiol&gt

Methoxy estradiol

Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17β)-

2-Methoxy 17β-Estradiol

2-METHOXYESTRADIOL USP/EP/BP

2-Methoxyestradiol (2MeOE2, NSC659853, 2ME2)

362-07-2 2-METHOXYESTRADIOL

2-Methoxy-β-estradiol

2-Methoxy-beta-estradiol 2-Methoxyestradiol

1, 3, 5(10)-ESTRATRIEN-2, 3, 17β-TRIOL 2-METHYL ETHER

(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol

362-07-2

363-07-2

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