CW069

ChemicalBook > CAS DataBase List > CW069

Product Name: CW069
CAS No.: 1594094-64-0
Chemical Name: CW069
Synonyms: CW069;CS-1425;CW069; CW 069;CW069 USP/EP/BP;CW-069,Inhibitor,Kinesin,inhibit,CW 069;(S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOIC ACID;2-[(2S)-2-(Benzylamino)-3-phenylpropanamido]-5-iodobenzoic acid;5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid;Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-
CBNumber: CB52681121
Molecular Formula: C23H21IN2O3
Formula Weight: 500.33
MOL File: 1594094-64-0.mol

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CW069 Property

Boiling point:: 666.0±55.0 °C(Predicted)
Density: 1.559±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: ≥50 mg/mL in DMSO; insoluble in H2O; ≥51.6 mg/mL in EtOH
form: solid
pka: 2.69±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22936
Product name: CW069
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 22936
Product name: CW069
Purity: ≥95%
Packaging: 5mg
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 22936
Product name: CW069
Purity: ≥95%
Packaging: 10mg
Price: $356
Updated: 2024/03/01

TRC

Product number: C857000
Product name: CW069
Packaging: 25mg
Price: $1075
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181226
Product name: CW069
Purity: >98%
Packaging: 250mg
Price: $1208.7
Updated: 2021/12/16

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CW069 Chemical Properties,Usage,Production

Description

CW069 is an allosteric inhibitor of KIFC/HSET (IC₅₀ = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC₅₀s = 86 and 181 μM, respectively).

Uses

CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.

References

[1]. watts ca, richards fm, bender a, et al. design, synthesis, and biological evaluation of an allosteric inhibitor of hset that targets cancer cells with supernumerary centrosomes. chem biol, 2013, 20(11): 1399-1410.

CW069 Preparation Products And Raw materials

Raw materials

Preparation Products

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1594094-64-0, CW069Related Search:

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CW069

CW069; CW 069

CS-1425

(S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOIC ACID

5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid

Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-

2-[(2S)-2-(Benzylamino)-3-phenylpropanamido]-5-iodobenzoic acid

CW069 USP/EP/BP

CW-069,Inhibitor,Kinesin,inhibit,CW 069

1594094-64-0

Inhibitors