CW069
- Product Name
- CW069
- CAS No.
- 1594094-64-0
- Chemical Name
- CW069
- Synonyms
- CW069;CS-1425;CW069; CW 069;CW069 USP/EP/BP;CW-069,Inhibitor,Kinesin,inhibit,CW 069;(S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOIC ACID;2-[(2S)-2-(Benzylamino)-3-phenylpropanamido]-5-iodobenzoic acid;5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid;Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-
- CBNumber
- CB52681121
- Molecular Formula
- C23H21IN2O3
- Formula Weight
- 500.33
- MOL File
- 1594094-64-0.mol
CW069 Property
- Boiling point:
- 666.0±55.0 °C(Predicted)
- Density
- 1.559±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- ≥50 mg/mL in DMSO; insoluble in H2O; ≥51.6 mg/mL in EtOH
- form
- solid
- pka
- 2.69±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 22936
- Product name
- CW069
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 22936
- Product name
- CW069
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 22936
- Product name
- CW069
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- C857000
- Product name
- CW069
- Packaging
- 25mg
- Price
- $1075
- Updated
- 2021/12/16
- Product number
- orb181226
- Product name
- CW069
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1208.7
- Updated
- 2021/12/16
CW069 Chemical Properties,Usage,Production
Description
CW069 is an allosteric inhibitor of KIFC/HSET (IC50 = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC50s = 86 and 181 μM, respectively).
Uses
CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.
References
[1]. watts ca, richards fm, bender a, et al. design, synthesis, and biological evaluation of an allosteric inhibitor of hset that targets cancer cells with supernumerary centrosomes. chem biol, 2013, 20(11): 1399-1410.
CW069 Preparation Products And Raw materials
Raw materials
Preparation Products
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